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Chii chinonzi HPMC?

HPMC Hydroxypropyl methylcellulose, inozivikanwawo se hypromellose, imwe yeasiri-ionic cellulose yakasanganiswa ethers.Iyo semi-synthetic, isingashande, viscoelastic polymer inowanzoshandiswa semafuta ekuzora muophthalmology, kana semubatsiri kana excipient mumishonga yemuromo.

Zita rechigadzirwa Hydroxypropyl methyl cellulose(HPMC)
Rimwe zita Hydroxypropyl methylcellulose,MHPC, methyl Hydroxypropyl cellulose
CAS Kunyoresa Nhamba 9004-65-3
Kuonekwa white fibrous kana granular powder
tsananguro yekuchengetedza S24/25

Izvo zvemuviri uye zvemakemikari zvimiro
Kuonekwa: chena kana inenge yakachena fibrous kana granular powder
Kugadzikana: Masori anogona kupisa uye haaenderani neakasimba oxidants.
Granularity;Chiyero chekupasa kwe100 mesh chaive chinopfuura 98.5%.Kupasa kwemaziso makumi masere i100%.Yakakosha saizi ye particle size 40 ~ 60 mesh.
Carbonization tembiricha: 280-300 ℃
Inooneka density: 0.25-0.70g / cm3 (kazhinji inotenderera 0.5g / cm3), chaiyo giravhiti 1.26-1.31.
Kuchinja kwemavara tembiricha: 190-200 ℃
Kushungurudzika kwepamusoro: 42-56dyne / cm mu 2% mhinduro yemvura
Solubility: soluble mumvura uye zvimwe zvinonyungudutsa, zvakadai sechikamu chakakodzera che ethanol / mvura, propanol / mvura, etc. Aqueous solution ine basa repamusoro.Kujeka kwepamusoro, kuita kwakagadzikana, kwakasiyana kutsanangurwa kwechigadzirwa gel tembiricha zvakasiyana, solubility shanduko ine viscosity, iyo yakadzika iyo viscosity, iyo yakanyanya kunyungudika, akasiyana maratidziro ekuita kweHPMC ane mutsauko, mhinduro yeHPMC mumvura haina kukanganiswa pH kukosha.
Basa repamusoro reHPMC rakadzikira nekudzikira kwemethoxyl yemukati, kuwedzera kwegel point uye kudzikira kwekunyungudika kwemvura.
HPMC inewo kugona kukora, munyu kuramba wakaderera dota hupfu, pH kugadzikana, kuchengetedza mvura, kugadzikana kwedimensional, yakanakisa kuumbwa kwemafirimu, pamwe nekusiyana kwakasiyana-siyana kupikisa enzyme, kupararira uye kubatanidza maitiro.

Nzira dzekugadzira
Iyo yakanatswa cotton cellulose inobatwa nelye pa 35-40 ℃ kwehafu yeawa, yakatsikirirwa, iyo cellulose inopwanyika uye yakwegura pa 35 ℃, kuitira kuti avhareji yepolymerization dhigirii ye alkali fiber inowanikwa mukati meinodiwa.Isa iyo alkali fiber mu kettle ye etherification, wedzera propylene oxide uye methane chloride zvakatevedzana, etherize pa 50-80 ℃ kwe 5h, yakanyanya kudzvanywa inenge 1.8mpa.Wobva wawedzera huwandu hwakakodzera hwehydrochloric acid uye oxalic acid yekugezesa zvinhu mu90 ℃ mvura inopisa kuti uwedzere huwandu.Kana mvura iri muzvinhu iri pasi pe60%, inoomeswa kusvika pasi pe5% nemhepo inopisa inoyerera pa130 ℃.Pakupedzisira, chigadzirwa chakapedzwa chinopwanyika uye chinoongororwa kuburikidza ne20 mesh.

Dissolution nzira
1, ese mamodheru anogona kuwedzerwa kuzvinhu nenzira yakaoma yekusanganisa.

2, inoda kuwedzerwa zvakananga kune yakajairwa tembiricha yemvura mhinduro, zvakanakisa kushandisa mvura inotonhora kupararira, mushure mekuwedzera kazhinji mumaminetsi gumi-90 kukora.
3. Mienzaniso yakajairika inogona kunyungudutswa mushure mekusanganiswa uye kupararira nemvura inopisa uye kuwedzera mvura inotonhora mushure mekukurudzira uye kutonhora.
4. Pakunyunguduka, kana chiitiko che agglomerating chikaitika, imhaka yekuti kusanganisa hakuna kukwana kana mamodheru akajairika anowedzerwa zvakananga kumvura inotonhora.Panguva ino, inofanira kumutswa nokukurumidza.
5. Kana mabubbles akaitika panguva yekuparara, anogona kubviswa nekumira kwemaawa 2-12 (nguva yakatarwa inobva pakuenderana kwekugadzirisa) kana nekutsvaira uye kudzvinyirira, kana nekuwedzera chiyero chakakodzera che defoaming agent.

HPMC inoshandisa
Inoshandiswa se thickener, dispersant, binder, exciphant, mafuta inodzivirira coating, filler, emulsifier uye stabilizer muindasitiri yemachira.Zvakare inoshandiswa zvakanyanya mukugadzira resin, petrochemical, ceramic, bepa, dehwe, mushonga, chikafu uye zvizorwa uye mamwe maindasitiri.

Chinangwa chikuru
1, indasitiri yekuvaka: sesimende dhaka rekuchengetedza mvura, retarder dhaka nekupomba.Mukupurasita, gypsum, putty poda kana zvimwe zvinhu zvekuvaka seanonamira, kunatsiridza daub uye kurebesa nguva yekushanda.Inoshandiswa kunama mataira eceramic, marble, kushongedza kwepurasitiki, paste kusimbisa mumiriri, achiri anogona kuderedza simende dosage.HPMC's yekuchengeta mvura kuita kunoita kuti slurry mushure mekushandisa haizove nekuda kwekuoma nekukurumidza uye kutsemuka, kuwedzera simba mushure mekuoma.
2, Ceramic kugadzira: inonyanya kushandiswa seyakanamatira mukugadzira chigadzirwa checeramic.
3, indasitiri yekupfekedza: muindasitiri yekupfekedza seyakakora, dispersant uye stabilizer, mumvura kana organic solvents ine yakanaka solubility.Sekubvisa pendi.
4, inki kudhinda: mune ingi indasitiri se thickener, dispersant uye stabilizer, mumvura kana organic zvinonyungudutsa vane yakanaka solubility.
5, purasitiki: yekugadzira mumiriri wekuburitsa, softener, lubricant, nezvimwe.
6, PVC: PVC kugadzirwa seanoparadzira, kumiswa polymerization gadziriro yePVC mikuru yekubatsira.
7, indasitiri yemishonga: kupfeka zvinhu;Membrane material;Rate-inodzorwa polymer zvinhu zvekuchengetedza-kuburitswa gadziriro;Stabilizing agent;Yakamiswa rubatsiro;Kunamatira pahwendefa;Inowedzera goo
8, Vamwe: zvakare inoshandiswa zvakanyanya mumatehwe, indasitiri yezvigadzirwa zvemapepa, kuchengetedza michero nemiriwo uye indasitiri yemachira.

Specific indasitiri application

Indasitiri yekuvaka
1, simende dhaka: kunatsiridza kupararira kwesemende - jecha, kuvandudza zvakanyanya mapurasitiki uye kuchengetwa kwemvura kwedhaka, kudzivirira kutsemuka kuve nemhedzisiro, kunogona kuwedzera simba resimende.

2, ceramic tile simende: kunatsiridza mapurasitiki edhaka redhaka dhaka, kuchengetedza mvura, kunatsiridza glue relay ye ceramic tile, kudzivirira hupfu.
3, asbestos uye imwe refractory coating: seyakamiswa mumiriri, liquidity yekuvandudza mumiriri, asi zvakare gadzirisa hwaro hweglue relay.
4, gypsum slurry: kunatsiridza kuchengetwa kwemvura uye kugadzirisa, kunatsiridza kunamatira kwechigadziko.
5, simende yakabatanidzwa: wedzera mu gypsum board nejoint simenti, kuvandudza fluidity uye kuchengetedza mvura.
6, latex putty: kunatsiridza fluidity uye kuchengetwa kwemvura ye resin latex based putty.
7, dhaka: sechinotsiva chechisikigo paste, inogona kuvandudza kuchengetwa kwemvura, kugadzirisa glue relay nechigadziko.
8, kupfekedza: seplasticizer ye latex coating, ine basa mukuvandudza kushanda kwekushanda uye fluidity yekuputira uye putty poda.
9, kupfapfaidza coating: kudzivirira simende kana latex kupfapfaidza chete zvinhu filler kunyura uye kunatsiridza kuyerera uye kupfapfaidza danda girafu zvine mhedzisiro yakanaka.
10, simende, gypsum yechipiri zvigadzirwa: sesimende - asbestos uye zvimwe hydraulic zvinhu zvinotsikirira molding binder, inovandudza fluidity, inogona kuwana yunifomu yekuumba zvigadzirwa.
11, fiber wall: nekuda kweiyo anti-enzyme inorwisa mabhakitiriya maitiro, sezvo binder yejecha madziro inoshanda.
12, imwe: inogona kushandiswa seyakaonda dhaka dhaka uye dhaka opareta basa rebubble inobata mumiriri.

Indasitiri yemakemikari
1, vinyl chloride, vinyl polymerization: sepolymerization kuturika stabilizer, dispersant, ine vinyl doro (PVA) hydroxypropyl cellulose (HPC) uye inogona kudzora kugoverwa kwechidimbu chimiro uye chidimbu.
2.
3. Mushonga wezvipembenene: wakawedzerwa kune mishonga yezvipembenene nemishonga yesora, unogona kuvandudza hunhu hwekunamatira pakupfapfaidza.
4, latex: kunatsiridza asphalt emulsion stabilizer, styrene butadiene rubber (SBR) latex thickener.
5, binder: sepenzura, krayoni inogadzira inonamira.

Indasitiri yezvizoro
1. Shampoo: kuvandudza viscosity uye kugadzikana kwemabhuru e shampoo, detergent uye detergent.
2. Mushonga wemazino: Kuvandudza kuyerera kwemushonga wemazino.

Indasitiri yezvokudya
1, citrus yemumagaba: kudzivirira mukuchengetedza nekuda kwekuora kweorenji glycosides uye kuchena metamorphism kuti uwane hutsva.
2, zvigadzirwa zvemichero inotonhora: wedzera muchero dova, ice medium, ita kuti kuravira kuve nani.
3, muto: soso, tomato muto emulsifying stabilizer kana thickening agent.
4, mvura inotonhora inovhara glazing: inoshandiswa kuchengetedza hove dzakaomeswa nechando, inogona kudzivirira kushanduka, kuderedzwa kwemhando, nemethyl cellulose kana hydroxypropyl methyl cellulose mhinduro yakavharidzirwa glazing, uye yozoomeswa nechando.
5, iyo yakanamatira yemapiritsi: sekugadzira kunamatira kwemapiritsi nemapiritsi, kusungirirwa uye kuputsika (kukurumidza kunyungudika uye kupararira kana uchitora) zvakanaka.

Pharmaceutical industry
1. Kupfekedza: iyo yekuputira inogadzirwa mu organic solvent solution kana aqueous solution yemapiritsi, kunyanya kune zvimedu zvakagadzirwa nespray coating.
2, inononoka mumiriri: 2-3 magiramu pazuva, nguva imwe neimwe 1-2G dosage, mumazuva 4-5 kuratidza mhedzisiro.
3, mushonga weziso: nekuti iyo osmotic pressure yehydroxypropyl methyl cellulose aqueous solution yakafanana nemisodzi, saka idiki kumaziso, wedzera mushonga wemaziso, semafuta ekuzosangana nemboni yeziso.
4, gelatinous agent: sechinhu chekutanga chegelatinous yekunze mushonga kana mafuta.
5, kuitisa mushonga: seanokora mumiriri, mumiriri wekuchengetedza mvura.

Furnace industry
1, midziyo yemagetsi: seceramic denser yemagetsi, bauxite ferrite magineti yekuumba inonamatira, inogona kushandiswa ne 1.2-propylene glycol.
2, glaze: inoshandiswa seceramic glaze uye porcelain ine enamel, inogona kuvandudza kubatana uye kugadzirwa.
3, refractory dhaka: wedzera mune refractory dhaka kana kukanda muchoto zvinhu, zvinogona kuvandudza mapurasitiki uye kuchengetwa kwemvura.

Mamwe maindasitiri
1, fiber: sekudhinda dhayi paste ye pigment, boron sango dhayi, munyu wakavakirwa dhayi, machira madhayi, mukuwedzera, mune kapok ripple processing, inogona kushandiswa nekupisa kuomesa resin.
2, bepa: rinoshandiswa kabhoni bepa rematehwe gluing uye kugadzira mafuta uye zvimwe zvinhu.
3, dehwe: seyekupedzisira lubrication kana kuraswa adhesive kushandiswa.
4, mvura-yakavakirwa inki: yakawedzerwa kune mvura-yakavakirwa inki, inki, seyakakora mumiriri, firimu rekugadzira mumiriri.
5, fodya: sechinamira chefodya yakadzokororwa.

Pharmacopoeia standard

Kwakabva uye zvirimo
Ichi chigadzirwa 2- hydroxypropyl ether methyl cellulose.Hydroxypropyl methylcellulose inogona kupatsanurwa kuita mhando ina zvichienderana nezviri mukati methoxy uye hydroxypropyl, zvinoti 1828, 2208, 2906, 2910. Zviri mukati meimwe neimwe inotsiva methoxy (-OCH3) uye hydroxypropoxy (-OCH2ChohCH3) inofanira kuenderana neyakasungirirwa. table.

hunhu
Ichi chigadzirwa chichena kana quasi-white fibrous kana granular powder;Kusanhuwirira.
Ichi chigadzirwa chinenge chisina kunyungudika muanhydrous ethanol, ether uye acetone;Kuzvimba mumvura inotonhora kuumba yakajeka kana zvishoma turbid colloid solution.

Kuzivisa
(1) Tora 1g yechigadzirwa, kupisa 100mL yemvura (80 ~ 90 ℃), fambisa nguva dzose, inotonhorera muchando chekugeza, uye gadzira mvura inonamira;Isa 2mL yemushonga muchubhu yekuyedza, zvishoma nezvishoma wowedzera 1mL ye0.035% anthracene sulfuric acid solution padivi pechubhu madziro, woiise kwemaminetsi mashanu, uye mhete yebhuruu-yegirinhi inoonekwa painterface pakati pezvinwiwa zviviri izvi.
(2) Huwandu hwakakodzera hweiyo viscous fluid pasi pekuzivikanwa (1) inodururwa pandiro yegirazi.Mushure mekuputika kwemvura, chidimbu chefirimu yakaoma inoumbwa.

check
1, p

Mushure mekutonhora, gadzirisa mhinduro ku 100g nemvura uye fambisa kusvikira yapera zvachose.Sarudza maererano nemutemo (Appendix ⅵ H, Chikamu II chePharmacopoeia, edition ya2010).PH kukosha kunofanira kuva 5.0-8.0.
2, viscosity
2.0% (g/g) kuturika kwakagadzirwa nekutora 10.0g yechigadzirwa uye nekuwedzera 90 ℃ mvura kuita huremu hwese hwesample uye mvura 500.0g seyakaoma chigadzirwa.Kumiswa kwacho kwakanyatso mutswa kweanenge maminitsi gumi kusvikira zvimedu zvanyatsopararira uye zvakanyorova.Kumiswa kwakanyoroveswa mubhati rechando uye kwakaramba kuchikurudzira kwemaminitsi makumi mana panguva yekutonhora.Silinda imwe chete inotenderera viscosimeter (ndJ-1 inogona kushandiswa kune sampuli ine viscosity isingasviki 100Pa · s, uye NDJ-8S inogona kushandiswa kune sampuli ine viscosity yakakura kupfuura kana yakaenzana ne100Pa · s, kana imwe yakakodzera viscosimeter yakakodzera) yakashandiswa pa20 ℃± 0.1 ℃, yakatemwa maererano nemutemo (yechipiri nzira ye ⅵ G mune appendix II yePharmacopoeia 2010 edition).Kana iyo yakanyorwa viscosity iri pasi pe600mPa · s, iyo viscosity inofanira kuva 80% ~ 120% yeiyo yakanyorwa viscosity;Kana iyo yakanzi viscosity yakakura kupfuura kana kuenzana ne600mPa · s, viscosity inofanira kuva 75% kusvika 140% yeakanyorwa viscosity.

3 Insoluble matter mumvura
Tora 1.0g yechigadzirwa, uise mubeaker, wedzera 100mL mvura inopisa pa80-90 ℃, zvimba kwemaminetsi gumi nemashanu, itonhodze mubhavhu rechando, wedzera 300mL mvura (kana zvichidikanwa, wedzera huwandu hwemvura zvakakodzera iva nechokwadi chekuti mhinduro yacho yakasefa), uye kurunga zvizere, sefa kuburikidza ne no.1 yakamira yakanyunguduka girazi crucible yakaomeswa kuti irambe ichirema pa105 ℃, uye chenesa beaker nemvura.Mvura yacho yakaseferwa mugirazi yakanyunguduka iri pamusoro uye yakaomeswa kuti irambe ichirema pa105 ℃, iine zvakasara zvisingapfuure 5mg (0.5%).

4 Kuomeswa uremu
Tora chigadzirwa ichi uye uomesa pa 105 ℃ kwemaawa maviri, uye kurasikirwa kwehuremu hakufaniri kudarika 5.0% (Appendix ⅷ L, Chikamu II, Pharmacopoeia 2010 edition).

5 Kupisa zvakasara
Tora 1.0g yechigadzirwa ichi uye utarise maererano nemutemo (Appendix ⅷ N, Chikamu II che pharmacopoeia 2010 edition), uye zvakasara hazvifaniri kudarika 1.5%.

6 heavy metal
Tora zvakasara zvakasara pasi pemasara e-incandescent, chengetedza maererano nemutemo (yechipiri nzira yeAppendix ⅷ H yechikamu chechipiri che2010 edition ye pharmacopoeia), ine simbi inorema haifaniri kudarika zvikamu makumi maviri pamamiriyoni.

7 arsenic munyu
Tora 1.0g yechigadzirwa ichi, wedzera 1.0g calcium hydroxide, sanganisa, wedzera mvura kumutsa zvakaenzana, yakaoma, kutanga nemoto muduku kuti carbonize, uye ipapo pa600 ℃ kupisa zvachose dota, kutonhora, kuwedzera 5mL hydrochloric acid uye 23mL mvura. kuputsa, tarisa maererano nemutemo (2010 edition ye pharmacopoeia ii Appendix ⅷ J nzira yekutanga), inofanira kuenderana nezvinodiwa (0.0002%).

Kutsunga kwemukati
1,methoxyl
Methoxy, ethoxy uye hydroxypropoxy (appendix VII F, Chikamu II, 2010 Edition yePharmacopoeia) yakatemwa.Kana nzira yechipiri (volumetric method) inoshandiswa, tora chigadzirwa, chiyera zvakarurama uye chiyere maererano nemutemo.Iyo yakayerwa methoxy chiyero (%) inobviswa kubva pachigadzirwa chehuwandu hwehydroxypropoxy (%) uye (31/75 × 0.93).
2, hydroxypropoxy
Methoxy, ethoxy uye hydroxypropoxy (appendix VII F, Chikamu II, 2010 Edition yePharmacopoeia) yakatemwa.Kana nzira yechipiri (yevhoriyamu nzira) ikashandiswa, tora chigadzirwa chinenge 0.1g, uremu nemazvo, sarudza maererano nemutemo, uye uwane.

Pharmacology uye toxicology
Hydroxypropyl methyl cellulose chikamu che cellulose methyl uye chikamu che hydroxypropyl ether, inogona kunyungudutswa mumvura inotonhora kuti igadzire viscous solution, zvimiro zvayo uye misodzi muzvinhu viscoelastic (kunyanya mucin) padyo, saka, inogona kushandiswa seyakagadzirwa. misodzi.Iyo nzira yekuita ndeyekuti iyo polymer inonamatira pamusoro peziso kuburikidza nekushambadza, kutevedzera chiito che conjunctival mucin, nekudaro inovandudza mamiriro eocular mucin kuderedza uye kuwedzera nguva yekuchengeta ziso mumamiriro ekudzikisa misodzi.Iyi adsorption yakazvimirira pane viscosity yemhinduro uye nekudaro inobvumira kunyorova kwekusingaperi kunyangwe kune yakaderera viscosity mhinduro.Uye zvakare, kunyorova kwekorneal kunowedzera nekudzikisa iyo yekubata Angle yeiyo yakachena corneal pamusoro.

pharmacokinetics
Hapana data ye pharmacokinetic yakashumwa yekushandiswa kwepamusoro kwechigadzirwa ichi.

zviratidzo
Moisten maziso nemisodzi isina kukwana uye bvisa kusagadzikana kwemaziso.

Usage
Vose vakuru nevana vanogona kuishandisa.1-2 madonhwe, katatu pazuva;Kana sezvakataurwa nachiremba.
Zvakaipa gadzirisa kutaura
Muzviitiko zvisingawanzoitiki zvinogona kukonzera kusagadzikana kweziso zvakadai sekurwadziwa kweziso, kusaona, kuenderera mberi kwe conjunctival congestion kana kutsamwa kweziso.Kana zviratidzo zviri pamusoro zviri pachena kana kuramba, rega kushandisa mushonga uye enda kuchipatara kunoongororwa.
taboo

Contraindicated muvanhu allergic kune ichi chigadzirwa.

Nyaya dzinoda kutarisirwa
1. Usabate musoro webhodhoro rekudonha kune eyelid uye dzimwe nzvimbo kudzivirira kusvibiswa
2. Ndapota chengetedza chigadzirwa kunze kwekusvikirwa nevana
3. Mwedzi mumwe mushure mekuvhura bhodhoro, hazvina kukodzera kuramba uchiishandisa.
4. Mishonga yevakadzi vane pamuviri uye vanoyamwisa: hapana mishumo yekukuvara kwekubereka kana mamwe matambudziko anokonzerwa neHYDROXYpropyl cellulose mumuviri wemunhu akawanikwa;Hapana maitiro asina kunaka akataurwa muvacheche panguva yekuyamwisa.Naizvozvo, hapana yakakosha contraindication kune vakadzi vane pamuviri uye vanoyamwisa.
5. Mishonga yevana: kana ichienzaniswa nemamwe mapoka ezera, hydroxypropyl methylcellulose muvana haisi kukonzera mamwe maitiro akaipa.Nokudaro, vana nevakuru vanogona kushandisa chigadzirwa ichi maererano nehurongwa hwakafanana.
6, mishonga yevakwegura: kushandiswa kwehydroxypropyl methylcellulose muvarwere vakwegura, zvichienzaniswa nemamwe mapoka ezera, hazvikonzeri migumisiro yakasiyana kana mamwe matambudziko.Saizvozvo, mushonga wemurwere wakakura hauna contraindication chaiyo.
7, chengetedzo: isina mhepo yekuchengetedza.

Safety performance
Dambudziko rehutano
Ichi chigadzirwa chakachengeteka uye chisina chepfu, chinogona kushandiswa sechikafu chekuwedzera, hapana kupisa, hapana kutsamwa kune ganda uye mucous membrane kusangana.Iyo inowanzoonekwa yakachengeteka (FDA1985).Nhamba inobvumirwa yezuva nezuva ndeye 25mg/kg (FAO/WHO 1985).Midziyo yekudzivirira inofanira kupfekwa panguva yekushanda.

Kukanganisa kwezvakatipoteredza
Dzivisa kusvibiswa kwemhepo kunokonzerwa neguruva rinobhururuka.
Njodzi dzemuviri nemakemikari: dzivisa kusangana nezvinopisa moto, uye dzivirira kuumba guruva rakakura munzvimbo yakavharwa kudzivirira njodzi dzinoputika.
Chengetedza zvinhu zvakatumirwa
Ngwarira kudzivirira kwezuva kubva pakunaya uye unyoro, dzivisa zuva rakananga, rakavharwa munzvimbo yakaoma.
Security term
S24/25: Dzivisa kusangana neganda nemeso.
Dzivisa kusangana neganda nemaziso.


Nguva yekutumira: Zvita-02-2021