Hydroxypropyl methyl cellulose HPMC , inozivikanwawo se hydroxypromellose, ichena kusvika kune-white cellulose ether powder kana granule ine mvura inotonhora inonyunguduka uye kusagadziriswa kwemvura inopisa yakafanana nemethyl cellulose.Hydroxypropyl boka uye methyl boka iether bond uye anhydrous glucose mhete ye cellulose yakasanganiswa, imhando yeisina-ionic cellulose yakasanganiswa ether.Iyo semi-synthetic, isingashande, viscoelastic polymer inowanzoshandiswa semafuta ekuzora muophthalmology, kana semubatsiri kana excipient mumishonga yemuromo.
1. Nzira yekugadzira
Kraft pulp ine αcellulose yemukati ye97%, intrinsic viscosity ye720mL / g uye avhareji fiber urefu hwe2.6mm yakanyikwa mu49% NaOH mhinduro pa40 ℃ kwemasekonzi makumi mashanu.Ipapo iyo pulp yakawedzerwa kubvisa yakawandisa 49% NaOH mhinduro yekuwana alkali cellulose.Chiyero chehuremu che (49% NaOH aqueous solution) kusvika (chakasimba chikamu chepulp) munhanho ye impregnation yaiva 200. Chiyero chehuremu cheNaOH mu alkali cellulose kusvika kusimba mu pulp ndeye 1.49.Iyo alkali cellulose yakawanikwa (20kg) inoiswa mujacked pressure reactor ine kushushikana kwemukati, yobva yavharwa uye kucheneswa nenitrogen kuti ibvise zvakakwana okisijeni kubva kune reactor.Zvadaro, tembiricha mu reactor yaidzorwa pa60 ℃ uku kubvongodza kwemukati kuchiitwa.
Ipapo 2.4kg dME yakawedzerwa uye tembiricha mureactor yakadzorwa kusvika 60 ℃.Mushure mekuwedzera kwe dimethyl ether, methylene chloride yakawedzerwa kuita molar ratio yemethylene chloride kuNaOH mu alkaline cellulose 1.3, propylene oxide yakawedzerwa kuita huremu hwepropylene oxide kuti huve hwakasimba mu pulp 1.97, uye tembiricha mu reactor. yaidzorwa kubva pa60 ℃ kusvika ku80 ℃.Mushure mekuwedzera chloromethane uye propylene oxide, tembiricha mureactor yakadzorwa kubva pa80 ℃ kusvika 90 ℃.Uye zvakare, kuita kwakatora maminetsi makumi maviri pa90 ℃.
Gasi rinobva radonhedzwa kubva mureactor uye crude hydroxypropyl methyl cellulose inobviswa kubva kune reactor.Tembiricha ye crude hydroxypropyl methyl cellulose yaive 62 ℃.Yema iyo yakawedzera 50% particle size mucumulative huremu zvichienderana nekugovera saizi yechikamu zvichienderana nereshiyo yecrude hydroxypropyl methyl cellulose kuburikidza nekuvhurwa kwesefa shanu, imwe neimwe iine saizi yekuvhura yakasiyana.
Nekuda kweizvozvo, avhareji saizi yezvikamu zvakakasharara yaive 6.2mm.Iyo yakawanikwa crude hydroxypropyl methyl cellulose yakaunzwa mune inoenderera biaxial kneader (KRC kneader S1, L / D = 10.2, mukati vhoriyamu 0.12 L, kutenderera kumhanya 150rpm) nekumhanya kwe10kg / hr, uye yakaora crude yakawanikwa hydroxypropyl methyl cellulose.Nekuda kwezviyero zvakafanana uchishandisa zvidzitiro zvishanu zvine masaizi akasiyana ekuvhura, avhareji saizi yaive 1.4mm.Kuwedzera 80 ℃ mvura inopisa kune yakaora crude hydroxypropyl methyl cellulose mutangi ine tembiricha yekudzora bhachi.huwandu hwehuremu hwehuwandu hweiyo yakaora crude hydroxypropyl methyl cellulose kusvika kuhuwandu hwese slurry ndeye 0.1, uye slurry inowanikwa.Iyo slurry yakasimudzwa pane inogara tembiricha ye80 ℃ kwemaminetsi makumi matanhatu.
Zvadaro, slurry inopiwa kune inotenderera ye 0.5 RPM uye pre-heated rotary pressure filter (BHS Sonthofen products).Tembiricha ye grout ndeye 93 ℃.Shandisa pombi kupa slurry, pombi discharge pressure ndeye 0.2mpa.Saizi yekuvhura yeiyo rotary pressure sefa ndeye 80μm, uye nzvimbo yekusefa ndeye 0.12m2.Iyo slurry inopihwa kune inotenderera pressure sefa inosefa kuburikidza nesefa uye inoshandurwa kuita sefa keke.Iyo inoguma keke yekusefa inopihwa ne 0.3mpa chiutsi uye 95 ℃ mvura inopisa ine huremu reshiyo gumi.
Mvura inopisa inopihwa kuburikidza nepombi pamhepo yekuyerera ye0.2mpa.Mushure mekunge mvura inopisa yapihwa, 0.3mpa steam inopihwa.Zvadaro, mushure mekugeza zvigadzirwa zvinobviswa kubva pane sefa pamusoro ne scraper uye zvinobudiswa kunze kwemuchina wekugeza.Matanho kubva pakupa slurry kusvika pakuburitsa zvigadzirwa zvakagezwa anoitwa nguva dzose.Sekuyerwa uchishandisa kupisa - kuomesa hygrometer, mvura yemukati yechigadzirwa chakagezwa saka yakaburitswa yaive 52.8%.Zvigadzirwa zvakagezwa zvakaburitswa kubva ku rotary pressure sefa zvakaomeswa ne air dryer pa 80 ℃, ndokupwanywa muVictory mill kuti vawane hydroxypropyl methyl cellulose.
2.Application
HPMC chigadzirwa chinoshandiswa se thickener, dispersant, binder, emulsifier uye stabilizer muindasitiri yemachira.Zvakare inoshandiswa zvakanyanya mukugadzira resin, petrochemical, ceramic, bepa, dehwe, mushonga, chikafu, zvizorwa uye mamwe maindasitiri.
Nguva yekutumira: Mar-23-2022