Mishonga yePharmacedical ndeyemhando dzekunze uye dzekuwedzera dzakashandiswa mukugadzirwa kwemishonga nemirairo, uye chikamu chakakosha chegadziriro yemishonga. Semanyorero ezvakasikwa anotora zvinhu, cellherose ether is biodegradable, uye yakachipa, methylpropyl cellemenyl pharmaceutical excividents. Parizvino, zvigadzirwa zvemabhizimendi mazhinji emasero ether anonyanya kushandiswa pakati uye akaderera-ekupedzisira minda yeindasitiri, uye kukosha kwakawedzerwa hakuna kukwirira. Iyo indasitiri inoda nekukurumidza shanduko uye kusimudzira kuti uvandudze iyo yakakwira-yekupedzisira application yezvigadzirwa.
Musika kugona kwesamusha yemishonga yekunyepedzera yakakura
Femaceceucial excividents anotamba yakakosha basa mukusimudzira uye kugadzirwa kwembiridzo. Semuenzaniso, gadziriro dzekusunungura, zvinhu zvekushandisa zvakadai sekushandiswa kweCellulose zvinoshandiswa seyekugadzirira-gadziriro, mafirimu ekusunungurwa, anodzivirirwa-zvinogadzirwa zvinogadzirwa zvinodhaka. Gadziriro uye kugadzirira kwemvura-kusunungurwa kwakashandiswa kwakashandiswa zvakanyanya. Mune ino system, polymers yakadai sema cellulose ether inowanzo shandiswa sevatakuri vemishonga kuti vadzore mwero wekusunungura mumuviri mune imwe nguva yakatarwa yekuzadzisa chinangwa chekurapa.
Sekureva kwehuwandu kubva kuZialan kubvunza Dhipatimendi rekutsvaga, kune mazana mashanu emhando dzakanyorwa munyika yangu, asi kuenzanisa marudzi 1,500 (Panopfuura nemhando dze3000), kune marudzi makuru matatu, uye kune marudzi makuru, uye mhando dzichiri diki. Iko kusimudzira kugona kwemusika kwakakura. Zvinonzwisisika kuti yepamusoro gumi pharmaceudical emusika mumusika wemugodhi mishonga yeGerface
Nhanhatu pharmaceucal excivients cellulose ether
Consulater Cellulose ether is a general izwi renhevedzeri weCellulose Derivatives rakagadzirwa nekuita kweAlkali Cellulose uye kuenzura mumiririri pasi pemamwe mamiriro ezvinhu. Icho chigadzirwa umo maHydroxyl mapoka paCellulose MacRomolecules ari chikamu kana kutsiviwa zvachose nemapoka e-ether. Cellulose ana ana vana anoshandiswa zvakanyanya muminda yePetroleum, zvekuvakisa, zvipfeko, chikafu, mushonga, uye kwemazuva ese. Muminda dzakasiyana-siyana, zvigadzirwa zvegiredhi egiredhi ndezvekunyorwa pakati uye zvakakwirira-kupera minda yeindasitiri, ine yakakwirira yakawedzerwa kukosha. Nekuda kwekunetseka kwakasimba zvinodiwa, kugadzirwa kwemishonga yemishonga-giredhi cellulose ether zvakare kwakaoma. Zvinogona kutaurwa kuti mhando yezvigadzirwa zvechikwereti-giredhi zvinogona kumiririra hunyanzvi hwekutengesa cellulose ether mabhisikisi. Cellulose ether inowanzowedzerwa seye blocker, matsrumbo uye thickener yekugadzira matanda ematres, ekusunungura microcapsues inobatanidza zvinhu, zvinoshamisa-zvinodhaka-zvinodhaka mafirimu emidziyo, nezvimwe.
Sodium carboxymethyl cellelose
CarboxyMethyl Cellulose Sodium (CMC-na) ndiyo cellulose ether neiyo huru kugadzirwa uye kuputika kumba uye kunze kwenyika. Iyo ionic cellulose ether yakagadzirwa kubva kukotoni uye huni kuburikidza neayo neayo uye kuwedzerwa ne chloroacetic acid. CMC-NA is a anowanzoshandiswa pharmaceucal compient. Iyo inowanzoshandiswa seyakagadziriswa yekugadzirira kwakasimba, kusunganidzwa-kuri kuwedzera, kuremedza uye kumiswa kugadzirira kwemvura, uye zvinogona kushandiswawo seyenzi-soluble matrix uye mafirimu ekugadzira mafirimu. Zvinowanzoshandiswa semidziyo yakasarudzika yezvinodhaka uye yakasimudzirwa-sununguko matrix mumatiriya akasimbiswa (inodzorwa) gadziriso
Pamusoro peSodium CarboxyMethylcellosellose seMishonga Specicient, Croscarmelle Sodium inogona zvakare kushandiswa seyakafanana nemishonga. Croscarmellose Sodium (CCMC-NA) ndeyemvura-insoluble chigadzirwa cheCarboxyMetheselloseLellose Semumiriri weCrosslink Croscarmelose Sodium inoshandiswa sekuparadzanisa mahwendefa, makapu uye magirini mune gadziriro yemuromo. Inovimba neCapillary uye kuzvimba kwakashata kusatenderwa. Iyo ine yakanaka yekukoshesa uye yakasimba yekuparadzira simba. Zvidzidzo zvakaratidza kuti kukura kweCroscarmelose Sodium mumvura zvakakura kupfuura izvo zvezvakanyanya kuparadzira zvakadai senge-zvakadzika carmellose sodium uye hydated microcrystalline cellulose.
Methylcellose
Methyll Cellulose (mc) is is-ionic cellulose ether yakagadzirwa kubva kukotoni uye huni kuburikidza neaxhlization uye methyl chloride. MetHylcellose ine yakanakisa mvura solubility uye yakagadzikana muhuwandu hwePH2.0 ~ 13.0. Iyo inoshandiswa zvakanyanya mumishonga yemishonga, uye inoshandiswa mumapiritsi epurasitiki, jekiseni remukati, gadziriro dzePoralmic, miromo yemuromo, mapiritsi emuromo uye gadziriro dzemuromo uye gadziriro dzemuromo uye gadziriro dzemuromo uye gadziriro dzemuromo uye gadziriro dzemuromo uye gadziriro dzemuromo uye gadziriro dzemuromo uye gadziriro dzemuromo uye gadziriro dzemuromo uye gadziriro dzepfungwa. Pamusoro pezvo, mugadziriro-dzinosunungurwa-mc inogona kushandiswa seHydrophilic Gel Gel Gel Kugadzirira-Kuburitsa microcapses Coating Zvekushandisa, Sununguko-Sununguko-Inodhaka mafirimu emishonga, nezvimwe.
Hydroxyprupylmethylcellose
HydroxyPropyl methylcellose (HPMC) is is is-ionic cellolose inosanganiswa yakagadzirwa kubva kuCotton uye huni kuburikidza neayo uye methyl chloride. Izvo zvisina kufanira, zvisingabvumirwe, zvisiri-zvine chepfu, zvichinyura mumvura inotonhora uye yakakomberedzwa mumvura inopisa. HydroxyPropyl methylcellose ndeye cellulose yakasanganiswa ether kusiyana-siyana yavo yekugadzirwa, dosage uye mhando yakakurumidza kuwedzera muChina mumakore gumi nemashanu apfuura. Iyo zvakare imwe yeanonyanya kushandiswa mishonga yemishonga yekunyepedzera kumba uye kune dzimwe nyika. makore enhoroondo. Parizvino, kushandiswa kweHPMC kunonyanya kuratidzwa mune inotevera zvinhu:
Imwe yakafanana nekubhuroka uye kuparadzanisa. Semabhizimusi, HPMC inogona kuita kuti zvinodhaka zvive nyore, uye zvinogona kuwedzera mazana enguva mushure mekutora mvura, saka inogona kuvandudza zvakanyanya iyo yekunyungudza huwandu kana kuburitsa huwandu hwehwendefa. HPMC ine yakasimba viscosity, iyo inogona kusimudzira iyo tarisiro yemukati uye kugadzirisa iyo compress yezvinhu zvisina kugadzirwa zvine crisp kana brittle chimiro. HPMC ine viscosity yakaderera inogona kushandiswa seBinder uye kupaza, uye avo vane yepamusoro viscosity inogona kungoshandiswa chete sebhinzi.
Iyo yechipiri yakafanana nekuburitswa uye kudzora kuburitswa kwekugadzirira kwemuromo. HPMC chinhu chinowanzoshandiswa hydrogel matsrum zvinyorwa mukugadzirira-kusunungura gadziriro. Low-vcosity Giredhi (5-50mpa · (5-50mpa es) Hpmc inogona kushandiswa, viscositifier uye yakakwirira-viscosm $ HPMC inokonzeresa muguruva-gastrointestinal fluid, ine zvakanakira kuumbwa kwakanaka, fluidity yakanaka, yakasimba inodhaka kurodha simba, uye zvinodhaka kuburitsa hunhu husina kukanganiswa naP. Icho chakanyanya kukosha hydrophilic carrier mune yekugadzirira-gadziriro yekugadzirira uye inowanzoshandiswa sehydrophilic gel
Yechitatu yakafanana nemumiriri wefirimu rekugadzira firimu. HPMC ine yakanaka firimu-inogadzira zvinhu. Iyo firimu yakaumbwa neyunifomu, inoonekera uye yakaoma, uye hazvisi nyore kunamatira panguva yekugadzira. Kunyanya kune zvinodhaka zviri nyore kutora zvinyoro nyoro uye hazvina kugadzikana, kuishandisa seyekuparadzanisa chikamu kunogona kuvandudza kugadzikana kwemushonga uye kudzivirira iyo firimu inoshandura ruvara. HPMC ine akasiyana siyana viscossity yakatarwa. Kana ikasarudzwa nemazvo, hunhu uye kutaridzika kwematafura akabatanidzwa zvakakwirira kune zvimwe zvinhu. Iyo inowanzoshandiswa kusangana ndeye 2% kusvika 10%.
Chechina yakafanana nezvinhu zvemakapu. Mumakore achangopfuura, nekubuda kakawanda kwedenda remhuka dzemhuka, zvichienzaniswa neGelatin Capsies, Vegetables Capsules vava Darling nyowani yeiyo maindasitiri emishonga uye ezvekudya. PFIZER yeUnited States yakabudirira kubvisa HPMC kubva kune zvakasikwa zvidyarwa uye yakagadzirirwa VCaptm yemiriwo capsules. Kuenzaniswa neExchental Gelatin Hollow Capsiles Capsiles Capsies Iyo yekuburitsa zvinodhaka yekuburitswa inogadzikana, uye kusiyana kwemunhu madiki. Mushure mekuparadzirwa mumuviri wemunhu, haina kunyudzwa uye inogona kubhururuka chinhu chinobviswa kubva mumuviri. Panyaya yemamiriro ekuchengetedza, mushure mehuwandu hukuru hweyedzo, hazvingangoita bronle pasi pemamiriro ezvinhu akadzika, uye zvivakwa zveCapsule zvichiri kugadzikana mumamiriro ekunze, uye zviratidzo zvezvirimwa zvezvirimwa hazvina kukanganiswa nemamiriro ezvinhu akanyanya ekuchengetedza. Nenjodzi dzevanhu dzemari dzemvura uye shanduko yemishonga yeruzhinji pamba uye kunze kwenyika, iyo yemusika kudiwa kwezvirimwa capules ichakura nekukurumidza.
Yechishanu yakaita seyemumiriri anomiswa. Kumiswa-mhando yekugadzirira kwemvura inowanzoitwa clinsial dosage fomu, iyo iri hetegency inopararira system mune iyo insoluble yakasimba mishonga yakapararira mune inopararira mvura yekuparadzira mvura. Iko kusimba kwehurongwa kunotanga kunaka kwemhando yekugadzirira kwemvura yekugadzirira. HPMC collodal Solution inogona kuderedza iyo yakasimba-yemvura interfcial tenension, kuderedza iyo yemahara simba rezvikamu zvakasimba, uye kudzikamisa tsika yekuparadzira yechokwadi. Iyo inomisikidza kumhanyisa mumiriri. HPMC inoshandiswa seanoridza mhere yeziso, ine zvirimo zve 0.45% kusvika 1.0%.
Hydroxyprupyl cellulose
HydroxyPropyl Cellulose (HPC) is non-ionic cellulose ether yakagadzirwa kubva kukotoni uye huni kuburikidza neayo kuburikidza neayo HPC inowanzo kuvezwa mumvura pazasi 40 ° C uye huwandu hukuru hwepolar sol, uye kuita kwayo zvine hukama nezviri kuHydroxpropropyl group uye degree rePolymerization. HPC inogona kuwirirana nemishonga dzakasiyana-siyana uye ine yakanaka inertia.
Yakadzika-yakatsiva hydroxyprusterl cellulose (L-HPC) inonyanya kushandiswa sechipatara yekuparadza uye binder. -HPC inogona kuvandudza kuomarara uye kupenya kwehwendefa, uye kunogona kuitawo kuti iyo piritsi ifambe nekukurumidza, kuvandudza mhando yemukati yehwendefa, uye uvandudze iyo cuctive maitiro.
Yakanyanya kutsiviwa hydroxypropyl cellulose H-HPC ine yakanaka firimu-inogadzira zvivakwa, uye iyo firimu yakawanikwa yakaoma uye yakasarudzika, iyo inogona kufananidzwa neplasticzeers. Iko kuita kwefirimu kunogona kuwedzeredzwa nekuvhenganiswa nevamwe vanonyorova-vanokanda vamiriri, uye zvinowanzoshandiswa seye firimu kuunganidza mapiritsi. H-HPC inogona zvakare kushandiswa seye matsrum zvinyorwa kugadzirira matrix masisitimu ekusimudzira-matafura, ekusunungurwa-akasunungura pellets uye maviri-denderedzwa masisitimu ekusimbisa.
HydroxytHyl Cellulose
Hydroxethyl Cellulose (Hec) is non-ionic cellulose ether yakagadzirwa kubva kukotoni uye huni kuburikidza neaxylisization uye erafied ye ethylene oxide. Mumunda wekurapa, hec inonyanya kushandiswa seanoshanda, Colidal yekudzivirira mumiririri, anoparadzira mumiririri, oda-madutu, emuromo, piritsi rakasimba, capsule uye mamwe maficha. HydroxytHyl Cellulose yakanyorwa muUS Pharmacoeia / US National Formulary uye European Pharmacoeia, nezvimwe.
Ethyl Cellulose
Ethyl Cellulose (EC) ndeimwe yemvura inonyanya kushandiswa-insoluble cellulose inobva. EC isiri-ine chepfu, isina kugadzikana, kusakwana mumvura, acid kana alkali solution, uye solulies mune organic solhanol uye methanol. Kazhinji inoshandiswa solvent ndeye tluene / ethanol se4/1 (uremu) yakasanganiswa sol. EC ine akawanda mashandisirwo ezvinodhaka-zvinodhaka Sezvinoratidzwa zvinhu zvebetsero zvekugadzira zvinhu zvekusunungurwa-zvakaburitswa; Inogona zvakare kushandiswa zvakanyanya seyakakura zvinhu zvekugadzirira kuparadzirwa kwakasimba; inoshandiswa zvakanyanya mune tekinoroji yemishonga sechinhu chinogadzirwa firimu uye chinodzivirira kubhururuka, pamwe sebhuruu uye mutero. Sezvo kuunganidzwa kwekudzivirira kwehwendefa, kunogona kuderedza kunzwa kwehwendefa kune humidity uye kudzivirira mushonga kubva mukukanganiswa nekunyorova, kuora mwoyo; Zvinogona zvakare kuumba kusunungura gwele-gel layer, micrenecapsulate polymer, uye gonesa kuburitswa kwekusunungurwa kwezvinodhaka.
Bvisa zvikumbiro-zvinopera zvekupedza uye kukurumidza kushandurwa uye kusimudzirwa
Muchidimbu, mvura-soolable sodium carboxymelose, metdroxypressl meturyl cellulose inoshandiswa kune yavo inoshandiswa mune mfekisi emacoMCEPETICE uye zvishandiso zvekuburitsa zvekugadzirira zvemuromo, zvinokonzeresa mafirimu-kugadzira vamiririri, zvigadzirwa zvemakapu uye zvinodzamisa vamiririri. Kutarisa nyika, makambani mazhinji ekunze (shin-etu Japan, dow wolfe uye ashland yambiro yemishonga yekuChina muChina mune ramangwana, kusanganisa, uye kuve nekuwedzera kwavo basa ravo mundima iyi. application yekuisa mukati. DOW WOLFE yakazivisa kuti ichasimbisa kutarisa kwayo pane kuumbwa, zvinongedzo uye zvinodikanwa zveMusika weChinese gadziriro yekugadzirira, uye nekutsvaga kwayo kunovavarira kusvika pedyo nemusika. Dow makemikari Wolff cell Ashland ine zvigadziko zvekugadzira muBeijing, Tianjin, Shanghai, Nanjin, Kunshan naJiangmen, uye akaisa mari muzvikamu zvitatu zvekutsvagisa muShanghai uye Nanjing.
Sekureva kwehuwandu kubva kune webhusaiti yeChina Cellulose Association, muna 2017, kugadzirwa kweMusangano weCellulose Ather yaive makumi matatu nematanhatu matani, uye vhoriyamu yekutengesa yaive makumi matatu nemakumi matatu ematani. Muna 2017, iyo chaiyo yekutengesa vhoriyamu Cmc yaive matani zviuru makumi maviri nezvishanu, Pamusoro peHPMC (Kuvaka Kwakeri Giredhi), HPMC Zvigadzirwa, HPMC (HPMC (HPMC (HPMC (HPMC, HPC, HPMC, HPC. Domestic cellulose ether yakakurumidza kukurumidza kweanopfuura makore gumi, uye zvoudiswa zvave kutanga zviri munyika. Nekudaro, zvigadzirwa zvevakawanda cellulose makambani anonyanya kushandiswa pakati nepakati uye minda yakaderera yeindasitiri, uye kukosha kwakawedzerwa hakuna kukwirira.
Parizvino, manyorerwo emuchadenga ether enterprises ari mune yakaoma nguva yekushandurwa uye kusimudzira. Ivo vanofanirwa kuenderera mberi nekuwedzera kwechigadzirwa kutsvagisa uye nekuvandudza basa, kushandisa zvizere zveChina, kuti uwedzere kusimudzira, pinda munda wepakati nepakati peindasitiri, uye kuzadzisa bhizimusi uye rakasvibirira.
Tumira nguva: Jun-15-2023