HydroxyPropyl methylcellose (HPMC) uye methylcellose (McMC) uye methylcellulose (mc) ari maviri cellulose derivatives akashandiswa zvakanyanya mune mishonga yekushandisa nekuda kwezvivakwa zvavo. Kunyangwe kufanana kwavo, ivo vane misiyano yakasiyana mumamiriro emakemikari, zvivakwa, uye zvinoshandiswa zvinovaita kuti vakwanise kuve vakarongerwa zvakasiyana muindasitiri yemishonga.
Chemical composition uye chimiro
Hydroxyprusyl methylcellose (HPMC):
HPMC ndeyemakemikari yakagadziridzwa cellulose ether. Iyo inotorwa kubva ku cellulose nekuibata ne methyl chloride uye profylene oxide, iyo inosvitsa nzira (-Och3) uye hydroxpropyl (-ch2chohch3) mapoka muCellulose Backbone. Dhigirii rekutsiva Iyo DS inomiririra iyo nhamba yepakati yeiyo hydroxyl mapoka yakadzorerwa pane anhydroglucose unit, nepo ms inoratidza iyo avhareji nhamba yeiyo hydroxpremyl mapoka akasungirirwa.
MetHylcellose (MC):
MC ndechimwezve cellulose ether, asi haina kunyatsogadziridzwa ichienzaniswa neHPMC. Iyo inogadzirwa nekurapa cellulose ine methyl chloride, inokonzerwa nekutsiva kwemapoka ehydroxyl nemapoka mapoka. Uku kugadziridzwa kwakazara neiyo degree rekutsiva Iko kusavapo kwehydroxypruspropyl mapoka muMC anozvitsaurira kubva kuHPMC.
Zvivakwa zvemuviri
Solubility uye Glation:
HPMC inokandwa mumvura inotonhora uye inopisa, inogadzira mhinduro yebasa. Paunenge uchishongedza, HPMC iri pasi pegreengonees glation, zvichireva kuti inoumba gel kana ichipiswa uye inokonzeresa mhinduro pamusoro pekutonhora. Ichi chivakwa chinonyanya kubatsira mukudzorwa zvinodhaka zvinodhaka uye seyekuona kwekusimbisa mumvura mhinduro.
MC, kune rumwe rutivi, inonyudza mumvura inotonhora asi isingaoneki mumvura inopisa. Izvo zvinoratidzawo ramboti; Nekudaro, tembiricha yayo yeGreen inowanzo kuve yakaderera pane iyo yeHPMC. Hunhu uhwu hunoita kuti mc yakakodzera kune chaicho mishonga mishonga yekunyorera uko gadziriso yepazasi inobatsira tembiricha.
Viscosity:
Vese HPMC uye MC inogona kuwedzera zvakanyanya zvikwangwani zvemukati zvemvura, asi HPMC inowanzo kupa huwandu hwakawandisa hwemasokisi nekuda kwekutsiva kwakasiyana-siyana kwekutsiva. Iyi misiyano inobvumidza kudzora kwakanyatsojeka mukuumbwa kunoda chaiyo viscossity profiles.
Mashandiro emishonga yemishonga
HpMC:
Kudzora Kuburitsa Matrix mafomu:
HPMC yakawandisa inoshandiswa mukudzorwa kwakadzorwa kusunungura matrix mafomu. Kugona kwayo kuzvimba uye kuumba genel genel kusanzwisisana ne gastric mvura inobatsira kudzora iyo inodhaka yekuburitsa zvinodhaka. Iyo gel layer inoita sechipo, ichimanikidza kusiyana kwemishonga uye nekuwedzera kusunungurwa kwayo.
Firimu rinofamba-famba:
Nekuda kweiyo yakanaka firimu-yekuumba midziyo, HPMC inoshandiswa zvakanyanya mukuvhara mahwendefa uye pellets. Inopa chipinganidzo chekudzivirira kupokana nekunyorova, oksijeni, uye chiedza, kuvandudza kugadzikana uye mareru echigadzirwa chechigadzirwa. Pamusoro pezvo, HPMC Coatings inogona kushandiswa kuravira kuravira uye kuvandudza kutaridzika kwemapiritsi.
Binder mune piritsi mafomu:
HPMC inoshandirwawo seyakasungwa mune yakanyorova granulation maitiro. Iyo inovimbisa simba rekusimbirira remahwendefa, vaitungamira kusunganidzwa kwehombodo yemwana panguva yekumanikidza.
Kumisa uye kuunganidza mumiririri:
Mune zvemvura mafomu, HPMC inoshanda seyekuomiswa uye kwakasimba mumiririri. Yayo yakakwira viscosity inobatsira mukuchengetedza yunifomu yekugovera zvidimbu zvekumiswa uye zvinovandudza kuwirirana kwechimiro.
MC:
Piritsi kusunga:
MC inoshandiswa seyakagadzirwa mune piritsi mafomu. Iyo inopa midziyo yakanaka yekusunga uye yemakaniki simba kumahwendefa, ichirondedzera kutendeka kwavo pakubata nekuchengetedza.
Kuparadzanisa:
Mune zvimwe zviitiko, mc inogona kushanda seyakaora, mahwendefa ekubatsira kuputsa kuita zvidimbu zvidiki pakubata neye gastric fluids, nekudaro achifambisa zvinodhaka.
Yakadzorwa Kuburitswa Fomu:
Kunyangwe zvishoma zvakajairika kupfuura HPMC, MC inogona kushandiswa mukudzorwa kwakadzorwa. Maitiro ayo arermogelation anogona kuitwa kudzvanywa kudzora nhoroondo yezvinodhaka.
Kuremedza uye kusimbisa mumiririri:
MC inoshandiswa seyakakora uye inosimbisa mumiririri mune akasiyana mvura uye semi-yakasimba mafomu. Kugona kwayo kuwedzera viscosity kunobatsira mukuchengetedza kugadzikana uye homogeneity yechigadzirwa.
Zvikumbiro zvakanyatsoitika mumishonga
HpMc application:
Ophthalms gadziriro:
HPMC inowanzoshandiswa mumhinduro dzeOPHTHAMIL SOLUESS uye Gels nekuda kweiyo lubricating uye viscoelastic zvivakwa. Iyo inopa kuchengetwa zvinyoro-nyoro uye inowedzera nguva yekubatana kwemushonga neocular pamusoro.
Transdermal Dhizaina Systems:
HPMC inoshandirwa muTransdermal Patch
Mucoadhesive Fomu:
Iyo mucoadhesive Properties yeHPMC inoita kuti iite yakakodzera buccal, nasal, uye vaginal zvinodhaka zvekutakura zvinodhaka, kuvandudza nguva yekugara yeiyo nzvimbo yekushandisa.
Mc application:
Nzvimbo dzepamusoro:
MC inoshandiswa mumakiromita epamusoro, Gels, uye mafuta emazwi azvinoita senge mumiririri uye akaomarara, achivandudza kupararira uye kuwirirana kwechigadzirwa.
Chikafu uye Nutrachicicals:
Kupfuura mishonga, mc inowana zvikumbiro muzvikafu uye zvechikafu zvechikafu seyekuchengetera, emulsifier, uye stabilizer, inopa kune zvigadzirwa uye kugadzikana kwezvakawanda zvakashata.
Mukupfupikisa, HPMC uye MC zvese zvakakosha cellulose Derivatives nehurongwa hwakasiyana hunovaita kuti vakwanise kuve vakakodzera kune dzakasiyana siyana mishonga. HPMC, neyakafanana neyakajairwa mvura mumvura inopisa uye inotonhora, uye kukwikwidza kwemafirimu ekugadzira, inonyanya kufarirwa kuburitswa kwekudzorwa, mahwendefa ebiriya, uye gadziriro yePolthalem. MC, apo nyore kuumbwa, inopa zvakareruka zvakanaka mukutonhorera kwemvura inotonhora uye kudzikisira kwegwenzi Kunzwisisa misiyano yezvivakwa zvavo zvemakemikari, zvivakwa zvemuviri, zvinoshanda zvinobvumidza maFlogulators kuti asarudze cellulose yakakodzera cellulose kuti isangane nezvinodiwa zvechinangwa chechigadzirwa.
Kutumira Nguva: Kukadzi-18-2025