Nhau

Hydroxypruppropyl methylcellose. Icho chinhu chakanakisa chigadzirwa chekugadzirira kwemafirimu emvura-mavara.

Firimu remvura rakaputika riripo rudzi rutsva rwegirini regirini rekutakura zvinhu, izvo zvakagamuchira zvakanyanya kutarisisa muEurope neUnited States nedzimwe nyika. Izvo hazvisi chete zvakachengeteka uye zvakaringana kushandisa, asi zvakare inogadzirisa dambudziko rekurongedza marara. Parizvino, mafirimu emvura anonyanya kushandisa zvinhu zvepamberi-zvakadai sePolyvinyl doro uye polyethylene oxide seyakagadzirwa. Petroleum is is is is is is is is is is is is is is is is is is is is is is is ishandiso, uye yakakura-chiyero yekushandisa ichaita kuti kushomeka kwezvinhu. Kune zvakare mafirimu emvura-manyorerwo anoshandisa zvinhu zvakasikwa senge strarin uye protein seyakagadzirwa zvinhu, asi mafirimu emvura aya ane mashura ane midziyo yakaipa. Mune ino bepa, rudzi rutsva rwemvura-runyararo rwekuputika rwakagadzirirwa nemhinduro casting nzira yekugadzira firimu uchishandisa hydroxyproproplosellose seyakagadzirwa zvinyorwa. Mhedzisiro yekuvhara yeHPMC firimu-inogadzira tembiricha uye yemafirimu-ekugadzira tembiricha pane kusimba kwesimba. Glycrol, Sorbitol uye Glutarldehyde akashandiswa zvimwezve kugadzirisa maitiro eHPMC mvura-yekuputika pafirimu. Pakupedzisira, kuitira kuti uwedzere kushandiswa kweHPMC yemvura-yekukanda firimu mune zvekudya zvekudya, bamboo Leaf Atiloxidant (AOB) yakashandiswa kugadzirisa iyo antioxidant zvivakwa zveHPMC yemvura yeHPMC yemvura yeHPMC. Zvikuru zviwanikwa ndezvekutevera:

(1. Kana iyo HPMC yekuvhara iri 5% uye iyo firimu inogadzira tembiricha ndeye 50 ° C, zvinhu zvakazara zveHPMC firimu zviri nani. Panguva ino, simba rakafanana rinenge ra126mpa, ma elongation pakuzorora anenge 31%, chiedza chinoputika ndi 90%, uye nguva yekunyungudika kwemvura ndeye 55min.

(2. Kana zviri mukati meGlycerol iri pakati pe005% uye 0.25%, mhedzisiro ndiyo yakanakisa, uye kuwanda kweHPMC yemvura-yeHPMC mapepa efirimu inosvika 50%; Kana izvo zvemukati zve sorbitol iri 0,15%, elongation yekuzorora inowedzera kusvika ku45% kana zvakadaro. Mushure meiyo HPMC yemvura-svutugadzike-yekukanda firimu yakagadziridzwa nejlycerol uye sorbitol, iyo Simba reSimba uye Zvivakwa zveOptical zvakadzikira, asi kuderera kwacho kwaive kusiri kwakakosha.

. Kana kuwedzera kweGlutarldehyde yaive 0.25%, iyo michina yemuchina uye zvivakwa zvezvinyorwa zvemafirimu akasvika kune yakasarudzika. Kana kuwedzera kweGlutarldehyde kwaive 0.44%, nguva yekunyungudika kwemvura yakasvika 135 min.

. Kana 0.03% AOB yakawedzerwa, iyo HPMC firimu yaive neyekukuvara kwegumi nenomwe yeDpp

Mazwi akakosha: Mvura-Yakavhenekera Pairating firimu; hydroxypruppropyl methylcellulose; Papurasitiki; kuyambuka-chinongedzo mumiririri; Antioxidant.

Zviri Mukati

Pfupiso ................................................................................... .. ................................................................................................................................. ..

Abstract ...........................................................................................................................................................................i

Zviri Mukati ............................................................................... ... ....................................................................... .. ............................... ..

CHITSAUKO CHEMA SANGANO ................................... .. ........................................................... .. .......... ..1

1.1water- soluble film ........................................................................................................................................................................................................................................................................................................................................................... ..

1.1.1Polyvinyl doro (PVA) mvura-shoma firimu ........................................................................... .. 1

1.1.2Polythylene oxide (Peo) firimu remvura rinopenya ................................................................................................... .. .....2

1,1.3stch-based Water-Solullofil Movie ................................................................................................................................................... ..

1.1.4 protein-based mvura-soluble films ............................................................................................................................................... ..

1.2 hydroxypruppropyl methylcellose ....................................................... .. ..

1.2.1 Iyo chimiro che hydroxyprupyl methylcellose ............................................................................................................................................... ..

1.2.2 mvura solubility ye hydroxyprupyl methylcellose ........................................................................................................................................ 4

1.2.3 Firimu-fomu yekugadzira zvivakwa ye hydroxyprupyl methylcellose ................................................................................. .4

1.3 Plastintication kugadziridzwa kwehydroxypropyl methylcellose firimu ....................................... .. .. .. ..

1.4 kuyambuka-kubatanidza kugadziridzwa kwehydroxyprishlpyl methylcellose firimu ................................................ .5

1.5 Antioxidative Properties yeHydroxyPropyl Methylcellose firimu ............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... .. 5

1.6 chikumbiro chemusoro wacho ................................................................................................... .. ........................................................................... .. .7

1.7 Zvinyorwa Zvemukati ............................................................................................................................................................................................... .. ......... ..

Chapter 2 Preparation and Properties of Hydroxypropyl Methyl Cellulose Water-Soluble Packaging Film………………………………………………………………………………………………………………………………….8

2.1 Nhanganyaya ................................................................................................................................................................................................. .. 8

2.2 Kuedza Chikamu .......................................................................................................................................... ........................................................................... .. .8

2.2.1 Zvigadzirwa zvekuedza uye zviridzwa ........................................................................................... .. ......... ..8

2.2.2 Kugadzirira Kugadzirira ........................................................................................................................................................... .. ..

2.2.3 chimiro uye kuongororwa kwekuita ................................................................................................................................................................................................................... ..

2.2.4 Kugadziriswa kwedatha .............................................................................................. ....................................................................... .. ......... .. 10

2.3 Mhedzisiro uye hurukuro ........................................................................................................................................................................... 10

2.3.1 Mhedzisiro yemufirimu-fomu yekugadzirisa mhinduro pane HPMC yakatetepa mafirimu ... 10

2.3.2 Servess yefirimu yekuumbwa tembiricha paHPMC yakatetepa mafirimu ...

2.4 Chitsauko Chitsauko ................................................................................................................................................. .. 16

CHITSAUKO 3 ZVINOGONESESA PAKUTI PAKUTI HPMC Mvura-Yakadzika PaChigina Mafirimu ....................................................................................................................................................... ..

3.1 Nhanganyaya ....................................................................... ..

3.2 Kuedza Chikamu ............................................................................................................................................... .. ......... ..1.17

3.2.1 Zvigadzirwa zvekuedza uye zviridzwa ................................................................................................................................................................................................................................................................................................................................................................................................... .. 17

3.2.2 Kugadzirira Kugadzirira .................................................................................................................................................................

3.2.3 Mamiriro ezvinhu uye Kugadziriswa Kwekuita ................................................................................................................................................................................................................ .18

3.2.4 Kugadziriswa kwedatha ....................................................................................... .. ............................................. ..

3.3 Mhedzisiro uye Kukurukurirana .................................................................................................................................................................... 19

3.3.1 Mhedzisiro yeGlycerol uye Sorbitol pane infrared yekunyora spectrum yeHPMC yakaonda mafirimu ...

3.3.2 Mhedzisiro yeGlycerol uye Sorbitol paXDT Patterns yeHPMC yakatetepa mafirimu ...

3.3.3 Mhedzisiro yeGlycerol uye Sorbitol pane iyo Mechancal Properties yeHPMC yakatetepa mafirimu ...

3.3.4 Mhedzisiro yeGlycerol uye Sorbitol pane iyo Optical Properties yeHPMC Films ............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... ..

3.3.5 Simba reGlycerol uye Sorbitol pane iyo mvura solubility yeHPMC mafirimu .......... 23

3.4 Chitsauko Pfupiso .................................................................................................................................................................................................24

Chitsauko 4 mhedzisiro yekuchinjika vamiririri paHPMC yemvura-soluxy Pairating mafirimu ................................................................................................................................................................................................... ..

4.1 Nhanganyaya ....................................................................... .. 25

4.2 Kuedza Chikamu ....................................................................................................................................................... 25

4.2.1 Zvigadzirwa zvekuedza uye zviridzwa ............................................................................... 25

4.2.2 Kugadzirira Kugadzirira ............................................................................................................................... ..

4.2.3 Mazwi uye Kugadziriswa Kwekuita ........................................................... .. ..........26

4.2.4 Kugadziriswa kwedatha ............................................................................... .. ............................................. ..

4.3 Mhedzisiro uye hurukuro ................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 27

4.3.1 Infrared quorred spectrum yeGlutarldehyde-Crosslinked HPMC yakatetepa mafirimu ...

4.3.2 XDR Pattarns yeGlutarldehyde Cross-Yakabatanidzwa HPMC yakaonda mafirimu .................................27

4.3.3 Mhedzisiro yeGlutareldehyde pane iyo mvura solubility yemafirimu eHPMC ..................... ..28

4.3.4 Mhedzisiro yeGlutareldehyde pane iyo Mechancal Properties yeHPMC yakatetepa mafirimu ... 29

4.3.5 mhedzisiro yeGlutareldehyde pane iyo Optical Properties yeHPMC mafirimu ...........................................................................

4.4 Chitsauko Chitsauko ................................................................................................................................................... .. 30

CHITSAUKO 5 Natural Antioxidant HPMC Mvura-Sholuble Pacing firimu ....................................... .. ..31

5.1 Nhanganyaya ................................................................................................................................................................... 31

5.2 Kuedza Kwekuedza ....................................................................................................................................................................... 31

5.2.1 Zvigadzirwa zvekuedza uye zviridzwa zvekuedza ................................................................................................................................................................. 31

5.2.2 Kugadzirira Kugadzirira ............................................................................................................................................................................................................................32

5.2.3 Mazwi uye Kugadziriswa Kwekuita ................................................................................................... 32

5.2.4 Kugadziriswa kwedata ............................................................................................................... .. ............................................................................................................... 33

5.3 Mhedzisiro uye kuongororwa ........................................................................................................................................................... ..

5.3.1 FT-IR analysis ………………………………………… ……………………………………………… ………… 33

5.3.2 XDR kuongorora ........................................................................................................................................................................................................... ..

5.3.3 Antioxidant Properties ................................................................................................................................................................................................................................................................................................................. 34

5.3.4 Solubility yemvura ............................................................................................................................................... .. ......... .35

5.3.5 mimhanzi zvivakwa ............................................................................................................................................................................... .. ..36

5.3.6 Optical performance ……………………………………………… …………………………………………37

5.4 Chitsauko Pfupiso ........................................................................................................................................................................... .. ......... .37

CHITSAUKO 6 Mhedziso ............................................................... .. ............................................... .. .. ..39

Reference .................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 40

Tsvagurudzo dzinobuda panguva yeDhigirii Zvidzidzo ............................................................................................................... .. .. .. .. .. ..

Kubvuma ............................................................................................................................................................................................... .. ......... ..

CHITSAUKO CHEMA SANGANO

Sekureva kwechiitiko cheGreenatidziro yezvinhu, firimu remvura rakarongedzwa rakashandiswa zvakanyanya muchirongwa chezvigadzirwa zvakasiyana-siyana mune dzimwe nyika (dzakadai seUnited States, Japan, France, nezvimwe. Firimu rakazara nemvura, sezita rinoreva kuti, firimu repurasitiki rinogona kunyungudika mumvura. Iyo yakagadzirwa nemidziyo yemvura inokandwa yemvura inogona kunyungudika mumvura uye yakagadzirirwa neyakagadziriswa firimu-fomu. Nekuda kwezvivakwa zvaro zvakakosha, zvakakodzera kwazvo kuti vanhu vatore. Naizvozvo, vazhinji vatsvagiri vakatanga kuteerera kune izvo zvinodiwa nekudzivirira kwezvakatipoteredza uye zviri nyore [2].

1.1 Mvura-Soluble Firimu

Panguva iripo

1.1.1 Polyvinyl doro (PVA) mvura-shoma firimu

Parizvino, mafirimu emvura anonyanya kushandisa mvura munyika ari kunyanya kudzima mvura. PVA inyimi yeVinyl inogona kushandiswa neBhaceria seCarbon Source, uye inogona kuve yerudzi rwepfungwa dzemafuta, kupokana kwakanyanya, solvent kuramba uye gasi zvinotyisa zvivakwa [4]. PVA firimu ine yakanaka michina yezvivakwa, kusimba kwakasimba uye kwakanaka kuchengetedza zvakatipoteredza. Iyo yakave yakashandiswa zvakanyanya uye ine mwero wakakwira wekutengesa. Iyo iri kure zvakanyanya kushandiswa zvakanyanya uye iyo yakakura mvura-inokatyamadza yemvura pafirimu mumusika [5]. PVA ine kunaka kwakanaka uye inogona kuiswa kuyamwiswa neMazvoRoorganisms kupa CO2 uye H2O muvhu [6]. Zvizhinji zvekutsvagisa pane mafirimu emvura zvino kuve nekuvandudza uye kusanganisa ivo kuti vawane mafirimu emvura ari nani. Zhao Linlin, Xiong Hanguo [7] akadzidza kugadzirira kwefirimu rekutakura mvura nePVA SEATHIONS OFTIME, Mushure me microwave kuomesa kweiyo yakawanikwa firimu, iyo nguva yekunyaradza mvura mumvura panguva yekupisa kwemakamuri ndeye 101s.

Kutonga kubva kumamiriro ezvinhu aripo ekutsvaga, Peva firimu rinoshandiswa zvakanyanya, mutengo wakaderera, uye zvakanakisa mune zvakasiyana siyana zvivakwa. Icho chinhu chakakwana kwazvo chemvura-chinorongedza-cluxy zvinyorwa zviripo. Nekudaro, sechinhu chakaburitswa-peturu, Peva isisiki isinga tsanangurike, uye maitiro ayo ekugadzira zvinhu anogona kusvibiswa. Kunyangwe iyo United States, Japan nedzimwe nyika dzakazvinyora sechinhu chisiri chepfu, kuchengetedzwa kwayo kuchiri kuvhurika kusvika mubvunzo. Zvese inhalation uye kumedza zvinokuvadza kumuviri [8], uye hazvigone kunzi yakakwana green chemistry.

1.1.2 Polyethyle oxide (Peo) Firimu remvura rinonzwika

Polyethyle oxide, anozivikanwawo sePolyethylene oxide, inzvimbo yemvura, inodzora mvura-yemvura inogona kusanganiswa nemvura mune chero ratio tembiricha [9]. Iyo formault formula yePolyethyle oxide is H - (- Och2ch2-) n-o, uye huwandu hwayo hwemanyorero huchakanganisa chimiro chayo. Kana iyo suremu racho riri mumhando ye200 ~ 20000, inonzi Polyethylene Glycol (Pelocal), uye uremu hwemvura hwakakura kupfuura makumi maviri emari dzinogona kunzi Polyethyle oxide (peo). Peo ine chena inoyerera granular poda, iri nyore kuita uye chimiro. Mafirimu eeo anowanzogadzirirwa nekuwedzera mapurasitiki, stabilizers uye mafirita kune peo enzvimbo kuburikidza neTermplastic kugadzirisa [11].

Peo firimu iri firimu rine mvura nemvura yakanaka kwazvo. PVA firimu imwe nzira [12]. Mukuwedzera, peo zvakare ine chokwadi chimwe, saka hazviwanzo kushandiswa muChigadzirwa Pairating [13].

1.1.3 Starch-based Water-Solux Film

Starch ndeyepanyama yakakwirira yemanyorerwo, uye mamorekuru ayo ane huwandu hwe hydroxyl mapoka, saka kune iyo starch yakanyungudika nekunyungudika uye kuwirirana, uye kuoma kwehunhu, uye zvakaoma kudyidzana nevamwe polymers. yakagadziriswa pamwe [14,15]. Soluluility yemvura yerudzi rusina kunaka, uye zvinotora nguva yakareba kuti uzive mumvura inotonhora, iyo yakasimbiswa starch, iyo, in starch yemvura, inowanzoshandiswa kugadzirira mafirimu emvura. Kazhinji, starch inogadziridzwa nemimwe nzira yakadai sekusimbisa, itstfing, yekubatanidza, uye kuyambuka kushandura chimiro chepakutanga, nekuvandudza mvura-inoshamisira yemvura ine starch [41].

Suma Ether zvisungo mumapoka emaptur. Nekudaro, pakudziya kwakadzika, kuwanda kwetsvina kwakanyanyisa kuzvidzora zvivakwa uye kuwanda kwehuwandu

1.1.4 protein-based mvura-solulla yakaonda

Mapuroteni ndeye biology inoshanda macromolecular chinhu chiri mumhuka nezvirimwa. Sezvo zvinhu zvakawanda zveproteni hazvizivikanwe mumvura pakudziya kwemakamuri, zvinodikanwa kugadzirisa solubility yemapuroteni mumvura pamhepo tembiricha kugadzirira mafirimu emvura kuti agadzirise mafirimu emvura ane mapuroteni sepuroteni. Kuti vazivise iyo solubility yemapuroteni, ivo vanofanirwa kuchinjwa. Nzira dzakajairika dzemakemikari dzakajairika dzinosanganisira depthalised, phthhaloamidation, phosphorylation, nezvimwe. Mhedzisiro yekushandurwa ndeyekuchinja chimiro cheTishu yeProtein, nekudaro achiwedzera iyo solubility, gelation, inoshanda senge mvura uye kugadzikana kusangana nezvinodiwa nekugadzirisa. Mapuroteni-anokonzerwa nemvura-sollble mafirimu anogona kugadzirwa nekushandisa ekurima uye sideline chigadzirwa marara emhuka, kana kudiwa kwezvigadzirwa zvepfuti, uye zvigadzirwa zvinovandudzwa uye zvine simba pane zvakasikwa [19]. Nekudaro, mafirimu emvura akagadzirirwa nemapuroteni akafanana neye matsrix ane mashini emvura uye akaderera mvura yekudziya pakudziya kana tembiricha yemakamuri, saka nzvimbo yavo yekushandisa yakamanikana.

Kuti upedze, ndezve kukosha kukuru kukudziridza chitsva, kuvandudza, mvura-yemvura kurongedza mafirimu ane mashandiro akanaka ekuvandudza kushomeka kwemafirimu emvura anowanikwa.

HydroxyPropyl methyl celler celler Iyo ine yakanaka mvura solubility uye firimu-inoumba zvivakwa, uye ine mamiriro ekugadzirira mafirimu emvura-svutugadzike.

1.2 hydroxypruppropyl methylcellose

HydroxyPropyl methyl Cellelose (HPDROPPROPYL methelose, HPMC kwenguva pfupi) Iyo-solux-solule cellulose inobviswa [21]. Hydroxypruppropyl methylcellose ane maitiro anotevera:

(1) zvizere uye zvinotsvuka zvinyorwa. Iyo yakabiwa zvinyorwa zvehydroxyprupyl methylcellose ndiyo yakanyanya kuwanda mheremalose cellalose pasi pano, ndeya organic inogadziridzwa zviwanikwa.

(2) zvakatipoteredza hushamwari uye bioderadable. Hydroxyprishpyl methylcellose haina chepfu uye chisina kukuvadza kumuviri wemunhu uye zvinogona kushandiswa mumushonga uye maindasitiri ezvekudya.

(3) yakakura kwazvo yekushandisa. Semukati memvura-soluble polymer.

1.2.1 Chimiro che hydroxypronyl methylcellose

HPMC inowanikwa kubva kune yakasikwa cellulose mushure mekunge alkalization, uye chikamu cherimwe polyhydropropropropropropropropropropropropropropropyl ether uye methyl inotsaurwa ne profylone oxide uye methyl chloride. Iyo general yekutengesa HPMC methyl yekutsiva degree kubva ku1.0 kusvika ku2,0, uye iyo hydroxpremypropyl yekutsiva degree kubva ku0.1 kusvika 1.0. Yayo molecular formula inoratidzwa mumufananidzo 1.1 [22]

Nekuda kweiyo yakasimba hydrogen kusungwa pakati pezvisikwa zvemasangano macromolecules, zvakaoma kunyungudika mumvura. Iyo solulogility yekutsauswa mheremalo mumvura yakadzikira nekuti mapoka eLEHER anounzwa kuti itsitswe cellulose, iyo inoparadza maHydrogen zvishamiso uye inowedzera iyo salubility mumvura [23] inowedzera solubility mumvura [23]. HydroxyPropyl methylcellose (HPMC) iri hydroxylkyl alkyled ether [21] Kuratidzwa kwakakwana kwekurongeka uye mupiro weboka rimwe nerimwe. - [Och2ch (Ch3)] NH3) NH 3) -Och3 iboka rekupedzisira-rekubhadhara, iyo nzvimbo yekuita ichave isingawanikwe mushure mekutsiva, uye ndezvepfupi-yakarongedzwa hydrophobic boka [21]. Iwo maHydroxyl mapoka pane imwe chete yakawedzerwa mapoka ebazi inosara pane glucose zvasara zvinogona kugadziridzwa nemapoka ari pamusoro apa, zvichikonzera zvivakwa zvakaoma uye zvivakwa zvinogadziriswa mukati meimwe simba renji [24].

1.2.2 Mvura Solubility yeHydroxypropyl methylcellose

HydroxyPropyl methylcellose ine zvakawanda zvakanaka zvivakwa nekuda kwechimiro chayo chakasarudzika, chinonyanya kuzivikanwa chacho ndechekuti ndechipi chinogadziriswa mvura. Inocheka mumhinduro ye collodal mumvura inotonhora, uye mhinduro ine zvimwe zvinhu zvemusoro, yakakwirira yekuwoneka uye yakagadzikana performance [21]. HydroxyPropyl methylcellose iri chaiko cellulose ethylceulose yakagadziridzwa neyekudzima-methelilines yekuwedzera. MetHyl Cellulose inoda kuiswa pa0 kusvika ku5 ° C kwemaminetsi makumi maviri kusvika makumi mana kuti uwane iyo yekugadzirisa chigadzirwa uye yakagadzikana viscosity [25]. Mhinduro yeHydroxyPropyl methylcellose chigadzirwa chete chinoda kuve kuma20-25 ° C kuzadzisa kugadzikana kwakanaka uye nekujeka kwakanaka [25]. Semuenzaniso, iyo purvitised hydroxypropyl methylcellose (granular chimiro 0,2-0.5 mm) inogona kuve nyore nyore mumhepo tembiricha kana iyo visikopo mhinduro ye4% inosvika 2000 centpoise pa2000 centpoise

1.2.3 Firimu-kugadzira zvivakwa zve hydroxypropyl methylcellose

Hydroxyprusyl methylcellose Solution ine yakanakisa firimu-inoumba zvivakwa, izvo zvinogona kupa mamiriro akanaka ekuvhara kwekuvhara kwegadziriro yemishonga. Iyo firimu yekuvhara yakagadzirwa nayo haina ruvara, isina kunaka, yakaoma uye yakajeka [21].

Yan Yanzhong [26] Wakashandisa bvunzo yeOrthogonal kuti uongorore mafirimu-mafirimu ekugadzira mafirimu e hydroxyprupylculose. Kuongorora kwacho kwakaitwa pamatanho matatu neakasiyana marara uye akasiyana soles sezvinhu. Mhedzisiro yacho yakaratidza kuti kuwedzera 10% hydroxypropyl methylcellose mu 50% Ethanol Solution yaive yakanyanya kugadzirwa mafirimu, uye inogona kushandiswa seyakagadzirwa mafirimu mafirimu ekusunungura-kusunungura mafirimu.

1.1 Plimistical kushandurwa kwehydroxypruppropyl methylcellose firimu

Sechisimba chakatsanangurwa, iyo firimu yakagadzirirwa kubva ku cellulose sezvo zvinhu zvakabikwa zvine simba uye kugona kuita, uye kune biodeable mushure mekuraswa, izvo zvisina basa kune zvakatipoteredza. Nekudaro, mafirimu asina kurongwa cellumlose ane hurombo, uye cellulose anogona kupererwa uye akashandurwa.

. Mhedzisiro yacho yakaratidza kuti elongation yekuzorora kweCellulose Acetate firimu yakawedzerwa ne36% uye 50% iyo misa yeTrietyl citrate uye acetyl tetrabutyl citrate yaive 10%.

Luo Qiusui et al [28] akadzidza zvinokonzerwa nePlasticzer Glycerol, Stearic acid uye glucose pane methylcellose membranes. Mhedzisiro yacho yakaratidza kuti methyl ye methyl cellose membrane yaive nani apo iyo Glycero yeiyo 1.5%, uye elongation ratio methyl Cellulose Memrene

Glycerol ndeye isina ruvara, inotapira, yakajeka, viscous mvura ine kuravira inotapira, inowanzozivikanwa se glycerin. Inokodzera kuongororwa kwemhinduro dzemvura, zvinyoro-nyoro, mapurasitiki, etc. Iyo inogona kunyungudika nemvura mune chero chikamu, uye yakaderera glycerol mhinduro inogona kushandiswa seyemafuta ekunyorovesa kuti unyorove ganda. Sorbitol, White Hygroscopic Powder kana Crystalline poda, mafaera kana granules, kusanzwisisika. Iyo ine mashandiro emanyoro ekunyorova uye kuchengetwa kwemvura. Kuwedzera zvishoma mukugadzirwa kwegamu uye pipi inogona kuchengeta chikafu chakapfava, kugadzirisa sangano uye kuderedza kuomesa uye kutamba basa rejecha. Glycerol uye Sormitol zvinhu zvese zvine mvura-zvinokonzeresa mvura, izvo zvinogona kusanganiswa nemvura-soluble cellulose anait. Ivo vanogona kushandiswa sevapurasitiki kuti cellulose. Mushure mekuwedzera, vanogona kuvandudza kuchinjika uye elongation pakuzorora kwema cellulose mafirimu. 29 29]. Kazhinji, kusunganidzwa kwemhinduro ndeye 2-5%, uye huwandu hweplasticzezer ndeye 10-20% ye cellulose ether. Kana zviri mukati mePlasticze yakanyanya kukwirisa, iyo shrinkage phenomenon yeiyo colloid yekushomeka ichaitika pakupisa kwakanyanya [30].

1.2 Crosslinking kugadziridzwa kwehydroxyprusyl methylcellose firimu

Iyo firimu-solulble firimu ine yakanaka mvura solubility, asi hazvitarisirwa kunyungudika kana ichishandiswa mune dzimwe nguva, dzakadai semakumbo embeu pakureba. Mbeu dzakaputirwa nefirimu rine mvura, iyo inogona kuwedzera huwandu hwekupona hwembeu. Panguva ino, kuitira kuchengetedza mhodzi, hazvitengere kuti iyo firimu ichanyungudika nekukurumidza, asi iyo firimu inofanira kutanga kutamba imwe nzira yekuchengetedza mvura pane mbeu. Naizvozvo, zvinodikanwa kuti uwedzere nguva yekunyaradza mvura yefirimu. 21].

Chikonzero nei hydroxyprupyl methylcellose chine huwandu hwemvura kuti ndedzekuti mitezo yekuyambuka, MetHylcellose anoderedzwa, nekudaro achideredza solubility yemvura yehydroxpropyl methylceose firimu, uye kuunganidza mari yekugadzira mari yakawanda, iyo inogona zvakare kuvandudza midziyo yemuchina yefirimu kune imwe nhanho. Iyo Aldehydes inoyambuka-yakabatana neHydroxyPropyl methylcellose inosanganisira Glutarldehyde inosanganisira Glutarldehyde inosanganisira Glutarldehyde ane mapoka maviri ealdehyde Izvo zvakachengeteka, saka Glutareldehyde anowanzoshandiswa seyekubatanidza mumiririri emijitendi yether. Iyo huwandu hwerudzi urwu rwekubatanidza-kuunganidza mumiririri mune mhinduro kazhinji 7 kusvika ku10% yehuremu hwe ether. Tembiricha yekurapa ingangoita 0 kusvika 30 ° C, uye nguva iri 1 ~ 120 maminitsi [31]. Iyo yekuyambuka-kuunganidza maitiro inoda kuitwa pasi pemamiriro ezvinhu emazwi. Kutanga, inorganic yakasimba acid kana organic carboxylic acid inowedzerwa kune iyo mhinduro yekugadzirisa iyo mhinduro kune anenge 4-6, uyezve dendeshs inowedzerwa kuti iite kuunganidza kuunganidza maitiro [32]. Aicds anoshandiswa anosanganisira HCL, H2So4, acetic acid, citric acid, uye zvakadaro. Iyo acid uye aldehyde inogona zvakare kuwedzerwa panguva imwe chete yekuita mhinduro yekuita iyo yekubatanidza maitiro mune iyo inodiwa pH range [33].

1.3 Antioxidative Properties yeHydroxyPropropyl methylcellose mafirimu

HydroxyPropyl methylcellose inopfuma mune zviwanikwa, zviri nyore kuumba firimu, uye ine maitiro akanaka ekuchengeta. Sechivanhu chengetedzo chekudya, chine hunyanzvi hwekuvandudza [34-36].

Zhuang Rongyu [37] Yakashandiswa HydroxyPropyl Methylcellose (HPMC) Inobiwa firimu, yakazvichengetedza pa200 Mhedzisiro yacho inoratidza kuti kuomarara kwemanyaoni neHPMC yekuvhara yakakwira kupfuura iyo isina kuunganidzira. Izvo zvakaratidzwawo kuti HPMC inodyarwa firimu inogona kunonoka kuchinja kwemavara ematehwe kubva pink kusvika kutsvuku kana ichichengetwa pa20 ℃.

. Mhedzisiro yacho yakaratidza kuti iyo anti-oxidation performance yeBayberry inobatwa neHPMC firimu yakave yakagadziriswa, uye kuora kwemari panguva yekuchengetedza yakaderera, uye mhedzisiro ye5% HPMC firimu yaive yakanyanya kunaka.

Wang Kaikai et al. . mhedzisiro yebasa. Mhedzisiro yacho yakaratidza kuti Riboflavin-composite HPMC-yakajairwa Bayberry Chibereko Chakanyanya kushanda

Mumakore achangopfuura, vanhu vane zvakakwirira uye zvakapfuura zvinodiwa pakuchengetedza chikafu. Vanotsvagurudza kumba uye kunze kwenyika vakachinja zvishoma nezvishoma kutsvagisa kwavo kwekutsvaga kubva pakudya kwekudya kuti vatore zvinhu. Nekuwedzera kana kupfira antioxidants muzviratidzo zvekutakura, vanogona kuderedza chikafu chekudya. Mhedzisiro yekuora chiyero [40]. Antioxididantial Antioxidants yakave nehanya zvakanyanya nekuda kwekuchengetedza kwavo kwakanyanya uye hutano hwakanaka pamuviri wemunhu [40,41].

Antioxidant yeBamboo mashizha (AOB kwenguva pfupi) inyaya yechisikigo yakasarudzika ine yakasarudzika yemasango ehupfupi bamboo kunhuhwirira kwemvura uye yakanaka yemvura. Izvo zvakanyorwa muNational Standard Gb2760 uye yakatenderwa nehumwe hushumiri hwehutano sechiwixidenant yechisikigo chikafu. Inogona zvakare kushandiswa seyakawedzera chikafu chezvigadzirwa nyama, zvigadzirwa zvemumvura uye chikafu chakavanzika [42].

Sun Lina Etc.P Ongorora zviyero zvikuru uye zvivakwa zve bamboo shizha antioxidants uye yakaunza kushandiswa kwe bamboo shizha antioxidants mune chikafu. Kuwedzera 0.03% AOB kune New Mayonnaise, iyo Antioxidant mhedzisiro ndiyo iri pachena panguva ino. Kuenzaniswa neiyo huwandu hwakaenzana hwetii polyphenol antioxidants, its antioxidant mhedzisiro iri nani pane iyo yetii polyphenols; Kuwedzera 150% kune doro paMG / L, iyo antioxidant zvivakwa uye kugadzikana kwekuchengetedza kwedoro kwakanyanya kuwanda, uye doro ine zvakanaka neyemi chemuviri. Nepo ichisimbisa mhando yekutanga yeiyo muviri wewaini, inowedzerawo kunhuhwirira uye kuravira kwemashizha e bamboo [43].

Mune pfupiso, hydroxyprusyl methylcellose ine yakanaka firimu-inoumba midziyo uye kuita kwakanaka. Iyo zvakare yakasvibira uye inosvibisa zvinhu, iyo inogona kushandiswa seyekuputika firimu mumunda wekutakura [44-48]. Glycerol uye Sorbitol ndiwo ese maviri-emvura-svutugadzike maplineti. Kuwedzera Glycerol kana Sorbitol kune Cellulose Film-Filming Film-Filming Film Glutaraldehyde chinhu chinowanzoshandiswa chinoshandiswa. Kuenzaniswa nedzimwe aldehydes, yakachengeteka, uye ine gradydehyde boka mumorekuru, uye kumhanya-muchinjiko kunomhanya kunomhanya zvakanyanya. Inogona kushandiswa seyakafukidzwa-inobatanidza shanduko ye hydroxypruppropyl methylcellose firimu. Inogona kugadzirisa iyo solubility yemvura yefirimu, kuti iyo firimu inogona kushandiswa mune dzimwe nguva [52-55]. Kuwedzera Bamboo Leaf Antioxidants kuenda kuHydroxyPropyl methylcellose Film kuti uvandudze maAsixidant Zvivakwa zveHydroxyProproplose Firimu uye kuwedzera mashandisiro ayo mukudya kwayo pakudya kwekudya.

1.4 Proposal yemusoro wenyaya

Kubva pamamiriro ezvinhu aripo ekutsvaga, mafirimu emvura anonyanya kuumbwa nePVA mafirimu, peo mafirimu, madhiragi-akavakirwa uye protein-yakavakirwa mafirimu emvura. Sezvinoratidzwa-based-based zvinyorwa, Peva uye peo hazvisi zvekuvandudza zviwanikwa, uye maitiro ekugadzira emidziyo yavo yekugadzira inogona kusvibiswa. Kunyangwe iyo United States, Japan nedzimwe nyika dzakazvinyora sechinhu chisiri chepfu, kuchengetedzwa kwayo kuchiri kuvhurika kusvika mubvunzo. Zvese inhalation uye kumedza zvinokuvadza kumuviri [8], uye hazvigone kunzi yakakwana green chemistry. Maitiro ekugadzira emararja-akavhenekerwa uye eprotein-anodzivirirwa mvura-manyorerwo-manyoreryama asina kukuvadza uye chigadzirwa chakachengeteka, asi vane zvakaipa zvekuumbwa kwefirimu rakaoma, nekukasira, uye kuputsa. Naizvozvo, kazhinji, ivo vanofanirwa kuve vakagadzirira kusanganisa nezvimwe zvinhu zvakadai sePVA. Iko kukosha kushandiswa hakuna kukwirira. Naizvozvo, kukosha kukuru kwekukudziridza chitsva, kuvhenekerwa, kwemvura-mvura-yekukanda mifananidzo yemifananidzo ine chekuita nekuvandudza hurema hwe firimu remvura iripo.

Hydroxyprusyl methylcellose chinhu chisikwa chepolymer, icho chisiri chete chakapfuma mune zviwanikwa, asi zvakare chidzorerwazve. Iyo ine yakanaka mvura solubility uye firimu-inoumba zvivakwa, uye ine mamiriro ekugadzirira mafirimu emvura-svutugadzike. Naizvozvo, pepa iri rinoda kugadzirira rudzi rutsva rwemvura-svutugadzike remvura ne hydroxyprosyl methylcellose seyakagadziriswa uye nekugadzirisa mamiriro ayo, uye nekuwedzera mapurasitiki akakodzera (Glycerol uye Sorbitol). ), kuyambuka Agent (Glutarldehyde), Antioxidant (Bamboo Leaf Antioxidant), kuti gadzirire zvivakwa zvakaringana, zvivakwa zvemvura, zvinokatyamadza mvura uye maAntioxidant zvivakwa. Methylcellestulose Water-Solulible Pairating firimu iri yeakanakisa kukosha kwekunyorera kwayo seyakagadziriswa mvura yekuputika yemvura.

1.5 Zvinyorwa Zvemukati

Zvinyorwa zvekutsvagurudza zviri zvinotevera:

1) Iyo HPMC yemvura-yekukwira mapepa ekuputika yakagadzirirwa neDhamba yekukanda nzira yekugadzira firimu, uye zvivakwa zvefirimu zvakaongororwa kuti udzidze firimu

2) Kuti udzidze Mhedzisiro yeGlycerol uye Sorbitol Plasticze pane iyo Mechancal Properties, SoluBulity yemvura uye Optical Properties yeHPMC Mvura-Inoputika Mafirimu.

4) Kugadzirira kweAOB / HPMC Mvura-Yakadzika paPorating firimu. Iyo oxidation kuramba, solubity yemvura, manhamba emvura uye zvivakwa zvezvinyorwa zveAOB / HPMC yakatetepa mafirimu aidzidzwa.

CHITSAUKO 2 Kugadzirira uye Zvivakwa zveHydroxyPropyl Methyl Cellulose Water-Soluble Paclating Firimu

2.1 Nhanganyaya

Hydroxypruppropyl methylcellose inzvimbo yakasikwa cellulose inobviswa. Izvo hazvisi zvekutakura, kusasvibisa, kuvandudza, kwemakemikari akagadzikana, uye ane yakanaka mvura solubility uye mafirimu-ekugadzira mafirimu. Icho chinogona kunge chinogona kurongedza mvura yekuvhora yemvura.

Chitsauko ichi chinoshandisa hydroxypropyl methylcellose seyakagadzirwa nehydroxyprospropropyl solution ye2% yekukanda mvura uye yefirimu yekugadzira mitezo pane yefirimu mechaniki, Optical, uye yemvura-solubility zvivakwa. Iyo Crystalline Properties yefirimu yakaratidzirwa ne X-Ray Film, Elze yeiyo Hydroxproproproplose Firimu yakaongororwa neTeil Test

2.2 Dhipatimendi Rekuedza

2.2.1 Zvigadzirwa zvekuedza uye zviridzwa

2.2.2 fungidziro kugadzirira

1) Kurera: kuyera imwe huwandu hwe hydroxyprusyl methylcellose ine chiyero chemagetsi.

1 membrane fluid. Yakagadzirirwa pa2%, 3%, 4%, 5% uye 6%.

3) Film Ford: Hydroxyprusyl methylcellose mvura-yekukanda mapepa ekuputika firimu ine ukobvu hwe25-50 μm yakagadzirirwa, uye iyo firimu yakabviswa uye yakaiswa mubhokisi rekuomesa rekushandisa. ②Premeraration yemafirimu akatetepa pane akasiyana-siyana-tembiricha panguva yekuomesa uye kuumbwa-firimu). Iyo hydroxyprusyl methylcellose mvura-yekukanda mapepa ekurongedza firimu ine ukobvu hwamakore makumi mana nemashanu akagadzirirwa, uye iyo firimu yakabviswa uye yakaiswa mubhokisi rekuomesa rekushandisa. Iyo yakagadzirirwa hydroxypropyl methylcellose mvura-yekukanda mapepa ekuputika firimu inotaurwa seHPMC firimu pfupi.

2.2.3 chimiro uye chiyero chekuita

2.2.3.1 Wide-Angle X-ray difFracction (xrd) kuongorora

Wide-Angle X-ray difFrate (xrd) inoongorora iyo crystalline mamiriro echinhu pane iyo molecular level. Iyo X-Ray Diffracometer yeArL / XTRA Rudzi Rwakaburitswa neTremo ArL Kambani muSwitzerland yakashandiswa pakutsunga. Kuyera Mamiriro ezvinhu: Iyo X-ray Source yaive nickel-yakasviba cu-kwi mutsara (40KV, 40ma). Iyo scan kona iri kubva 0 ° kusvika 80 ° (2θ). Scaning Speed 6 ° / min.

2.2.3.2 Mechanics Properties

Simba reChile Elongation paBreak (Kurambana Elongation) Inotaura nezve chiyero chehukuru kana iyo firimu yaputswa kusvika pakureba kwekutanga, inoratidzwa mu%. Uchishandisa Apstron (5943) Type miniature Electuration Old Teil Tensile Testing Machine, Ekupedzisira

2.2.3.3 Optical Properties

Optical Properties ndeye yakakosha chiratidzo chekujeka kwemafirimu ekuisa, kunyanya kusanganisira kuendesa uye haze yefirimu. Iko kuendesa uye haze yemafirimu akayerwa uchishandisa transmittance haze tester. Simudza muyedzo webvunzo nekachena, uise zvidimbu, zvinyoronyoro pamusoro pekuedzwa, chigadzirise nekapu yekubika, uye kuyera mwenje wefirimu mukamuri yekupisa (25 ° C uye 50% RH). Iyo sampu inoedzwa katatu nguva uye kukosha kwepakati kunotorwa.

2.2.3.4 Solubility mvura

Cheka 30mm Imwe neimwe yemuenzaniso yakayerwa katatu nguva uye kukosha kwepakati kwakatorwa, uye iyo yaive yaive min.

2.2.4 Kugadzirisa data

Iyo data yekuedza yakagadziriswa neExcel uye yakarongedzwa neSoftware Software.

2.3 Mhedzisiro uye Kukurukurirana

2.3.1.1 xrd mapatani eHPMC yakaonda mafirimu pasi peakasiyana firimu-kugadzira mhinduro

Fig.2.1 xrd yeHPMC mafirimu pasi pezvinyorwa zvakasiyana zveHP

Wide-Angle X-ray fidhraction ndiko kuongororwa kweiyo crystalline mamiriro ezvinhu ezvinhu zvakaenzana. Mufananidzo 2.1 Ko iyo Xrd difrabection pateni yeHPMC yakaonda mafirimu pasi peakasiyana firimu-yekugadzira mhinduro. Kune maviri maviri akasiyana mafiramu Inogona kuoneka kubva kune iyo yekuwedzera kweiyo HPMC yekuvhara, iyo misquircums yeiyo HPMC firimu yakatenderedza 9.5 ° uye 20.4 ° kutanga kusimudzirwa. Uye wobva wapererwa, iyo degree reiyo molecular gadziriro (yakarongedzwa gadziriro) yekutanga kuwanda uye yakabva yadzikira. Kana iko kusungwa kuri 5%, kurongeka kwakarongeka kweHPMC mamorekuru ndeye yakakwana. Chikonzero chePhenomenon pamusoro chingave kuti nekuwedzera kweHPMC kusvinura, huwandu hwekristaro nuclei mumhinduro yekugadzira firimu inowedzera, nekudaro kugadzira hpm molecular gadziriro yakawanda. Kana iyo HPMC yekushambadzira inopfuura 5%, iyo XRD DifFration Peak yeFirimu inopera. Kubva pane maonero ekufunga nezvecheni yeMolecular, apo iyo HPMC yekunyora, iyo yekunyora firimu yakanyanya kukwirisa, ichiita kuti zviome kucherechedzo uye isingakwanisi kurongeka munguva, nokudaro zvichiita kuti mwero wekuraira weHPMC Films yakadzikira.

2.3.1.2 Mechanics Properties yeHPMC yakaonda mafirimu pasi peakasiyana firimu-kugadzira mhinduro yekugadzirisa.

Simba reChile MaElongation pakuzorora ndiyo chiyero chekutamiswa kusvika pakureba kwehurefu hwefirimu pakuzorora. Kuyerwa kwezvinhu zvekushandisa zvemafirimu kunogona kutonga mashandisiro ayo mune mamwe minda.

Fig.2 Mhedzisiro yezvinhu zvakasiyana zveHPMC pane michina yezvimiro zveHPMC mafirimu

Kubva kuPif Kana iyo yekugadzirisa mhinduro iri 5%, iyo mechaniki midziyo yeHPMC mafirimu ari nani. Izvi zvinodaro nekuti apo iyo firimu-inogadzira mvura yakaderera, iyo yekufungidzira iri yakaderera, uye mamorekuru haagoni kurongwa nenzira yakarongeka, saka kugona kweiyo firimu kwakaderera uye zvivakwa zvaro zvemakaniki. Kana iyo firimu-inogadzira mvura yekuvhara ndeye 5%, iyo michina yemuchina inosvika kune yakakosha kukosha; Sezvo kusunganidzwa kwemweya wemufirimu kuchienderera mberi nekuwedzera, kudzikisira uye kusiyana kwemhinduro kwave kuomarara Naizvozvo, kusunganidzwa kwe5% HPMC firimu-kugadzira mhinduro ndiyo yakakodzera kwazvo. Iko kuita kweiyo firimu yakawanikwa zvakare iri nani.

2.3.1.3 Optical Properties yeHPMC yakaonda mafirimu pasi peakasiyana firimu-kugadzira mhinduro

Mune mafirimu ekutakura, kuputika kwechiedza uye haze akakosha paramita anoratidza kujeka kwefirimu. Mufananidzo 2.3 unoratidza maitiro ekuchinja ekuendesa uye haze yeHPMC mafirimu pasi peyakasiyana firimu-kugadzira mhepo ivhu. Zvinogona kuoneka kubva kune iyo yekuwedzera kwekusimbisa kweHPMC firimu-yekugadzira firimu, uye iyo yeHPMC yakaderera yakaderera, uye iyo haze yakawedzera zvakanyanya nekuwedzera kwekusimbisa kwemufirimu.

Fighters.3 Mhedzisiro yezvinhu zvakasiyana zveHPMC pane Optical Property yeHPMC mafirimu eHPMC

Pane zvikonzero zviviri zvikuru: Kutanga, kubva pamaonero ehuwandu hwekuvharirwa kweiyo yakapararira chikamu, kana kuderera kwakaderera, nhamba yenhamba ine simba rakaburukira pane zvimiro zvezvinhu [6]. Naizvozvo, nekuwedzera kwekusangana kweiyo HPMC firimu-yekugadzira mhinduro, densitions yefirimu dzakaderedzwa. Chiedza chinoputika chakadzikira zvakanyanya, uye iyo haze yakawedzera zvakanyanya. Chechipiri, kubva mukuongororwa kweiyo firimu-kugadzira maitiro, zvinogona kuve nekuti iyo firimu yakaitwa nemhinduro yekugadzirisa nzira yekugadzira firimu. Kuwedzera kwekunetseka kweechienda kunotungamira mukuderera kwekusanzwisisika kweiyo firimu kumusoro uye kuderera kweiyo Optical Properties yeHPMC firimu.

2.3.1.4 Soluubility yemvura yeHPMC yakatetepa mafirimu pasi pefirimu yakasiyana-inoumba yemvura

Iyo mvura solubility yemvura-soluble mafirimu ane hukama neyavo-yefirimu yekuumba. Cheka 30mm × 30mm mafirimu akagadzirwa nefirimu dzakasiyana kugadzira kutarisisa, uye kucherechedza iyo firimu ne "+" kuyera nguva yefirimu yekunyangarika zvachose. Kana iyo firimu yakaputira kana kuti inonamira kumadziro okubheka, chetambo. Mufananidzo 2.4 ndiyo trend dhizaini yeiyo mvura solubility yeHPMC mafirimu pasi peakasiyana firimu-inogadzira mapopoma emafirimu. Inogona kuoneka kubva kune iyo yekuwedzera kwefirimu-inogadzira firimu kusimbisa kwemvura, iyo nguva yekunyora yemvura yeHPMC mafirimu anova nguva refu, zvichiratidza kuti mvura yemvura yeHPMC mafirimu anoderera. Iyo inofungidzirwa kuti chikonzero chingangove icho nekuwedzera kwekusimbisa kweHPMC film-Fourning Solution, uye kushungurudzika kunosimbisa kuwanda kweiyo hpmc firimu mumvura uye kuderera kwemvura uye kuderera kwemvura.

Fig.4.4 Mhedzisiro yezvinhu zvakasiyana zveHPMC pane mvura solubil yeHPMC mafirimu

2.3.2 mhedzisiro yefirimu yekugadzira tembiricha paHPMC yakatetepa mafirimu

2.3.2.1 xrd mapatani eHPMC akaonda mafirimu pane akasiyana firimu achiumba tembiricha

Fig.2.5 XD yeHPMC mafirimu pasi pefirimu rakasiyana kugadzira tembiricha

Mufananidzo 2,5 unoratidza iyo XDS mapatani eHPMC yakaonda mafirimu pane akasiyana firimu kugadzira tembiricha. Maviri akasiyana mafiramu emakaki at 9.5 ° uye 20.4 ° akaongororwa kune iyo HPMC firimu. Kubva pamaonero ekuwedzera kweiyo misquircums inokatyamadza, nekuwedzera kwefirimu-kupisa tembiricha, iyo misoro yemisangano iyi yakatanga kuwanda uye ikazora simba, uye kugona kwemafuta kutanga kwakawanda uye kwobva waderera. Kana iyo firimu-yekugadzira tembiricha yaive 50 ° C, iyo yakarairwa gadziriro yemamolekyudhi kubva mukushamisika kwekushisa, iyo tembiricha yakakwira Sezvo iyo firimu-yekugadzira tembiricha inowedzera, mwero wechiyero chinowedzera, kufambisa kweiyo molecular kurongeka kwakakomberedza nekristaro Kana iyo firimu-yekugadzira tembiricha yakanyanya, kuumbwa kwemanyorero kwakanyanyisa kuita zvechisimba, kuumbwa kwekristaro. Naizvozvo, iyo crystallinity yeHPMC mafirimu anowedzera kutanga uyezve kuderera nekuwedzera kwefirimu kuumba tembiricha.

2.3.2.2 Mechenical Properties yeHPMC yakaonda mafirimu efirimu akasiyana kuumba tembiricha

Shanduko yefirimu inogadzira tembiricha ichave neimwe nhanho yekumanikidza pane iyo mechancal zvivakwa zvefirimu. Mufananidzo 2.6 unoratidza maitiro achinja kwesimba rekusimba uye elongation pakupera kweHPMC mafirimu pane akasiyana firimu achigadzira tembiricha. Panguva imwecheteyo, yakaratidza maitiro ekuwedzera kutanga uye obva aderera. Kana iyo firimu yakagadzira tembiricha yaive 50 ° C, simba reCendele uye elongation pakuzorora kweHPMC firimu, yaive 116 MPA uye 32%, zvichiteerana.

Fig.2.6 Mhedzisiro yefirimu inogadzira tembiricha pane michina yezvimiro zveHPMC mafirimu eHPMC

Kubva pamaonero emashoko eMolecular, yakakura kurongeka kwemamorekuru, iri nani kusimba kwesimba [64]. Kubva kuPif Kana iyo firimu yekuumba tembiricha iri 50 ° C, iyo mwero wehurongwa hwakanyanya kukura, saka Simba reHPMC Films Offer rinowedzera tembiricha, uye kukosha kwakanyanya kunoonekwa pane iyo firimu kuumba tembiricha ye50 ℃. MaElongation pakuzorora inoratidza maitiro ekuwedzera kutanga uye obva aderera. Chikonzero chingangove icho nekuwedzera kwekushisa, kurongeka kwakarongeka kwemamolekyuli kutanga uyezve kuderera, uye chimiro chekristaro chakaumbwa muPolymer matrix akapararira mune isina kugadzikana polymer matrix matrix matrix Muzviyero, chimiro chemuchengeti chakabatanidzwa chinoumbwa, chinoita chimwe chikamu chekushomeka [65], nekudaro zvinosimudzira macomputer yeHPMC firimu racho kuoneka penhema yekuumbwa kwe50 ° C.

2.3.2.3 Optical Properties yeHPMC mafirimu efirimu akasiyana kuumba tembiricha

Mufananidzo 2.7 ndiyo shanduko yekuchinja kwezvinhu zvemitambo yeHPMC mafirimu pane akasiyana firimu achigadzira tembiricha. Inogona kuoneka kubva kune iyo yekuwedzera kwefirimu inogadzira tembiricha, iyo yekufambisa yeHPMC zvishoma nezvishoma inowedzera, iyo chimedu zvishoma nezvishoma inoderera, uye zvivakwa zveHPMC zvishoma nezvishoma zvinopera zvishoma nezvishoma.

Fig.2.7 Mhedzisiro yefirimu inogadzira tembiricha pane Optical Property yeHPMC

Zvinoenderana neshanduro ye tembiricha nemamolekhudhi yemvura mufirimu [66], kana tembiricha yakaderera, mamorekuru emvura aripo mune yakasungwa mumvura, asi mvura iyi zvishoma nezvishoma ichavhota, uye hpmc iri mugirazi. Kuverengera kwemafirimu kunogadzira maburi muHPMC, uye ipapo kuparadzira kunoumbwa pamakomba mushure mekuremerwa kwerudzi ruri kurema Sezvo tembiricha inowedzera, zvikamu zvemanyorero zveHPMC tanga kufamba, maburi akaumbwa mushure mekuparadzwa kwemvura, mwero wekuputika anodzikira, uye kutururwa kunowedzera [68].

2.3.2.4 mvura solubility yeHPMC mafirimu pane akasiyana firimu kuumba tembiricha

Mufananidzo 2.8 unoratidza iyo mvura solubility curves yeHPMC mafirimu eHPMC pane akasiyana firimu achiumba tembiricha. Inogona kuoneka kubva kune iyo iyo nguva yekugadzirisa mvura yeHPMC films inowedzera nekuwedzera kwefirimu kuumba tembiricha, ndiko kuti, iyo solubility yemvura yeHPMC mafirimu eHPMC anova akaipa. Nekuwedzera kwekugadzira firimu tembiricha, mwero wekubuda kwemamolekyudhi emungudza uye kufambisa kwemanyorerwo, uye mwero wekuputika uri pamusoro pefirimu. Solubl Solubility yakaderedzwawo.

Fig.2.8 Mhedzisiro yefirimu inogadzira tembiricha pane mvura solubc yeHPMC firimu

2.4 Pfupiso yechitsauko chino

Muchitsauko chino, hydroxyprusyl methylcellose yakashandiswa seyakaisa zvinyorwa kugadzirira HPMC mvura-yekukanda mapepa ekuputika neSolution cast nzira yekugadzira firimu. Iyo Crystallinity yeHPMC firimu yakaongororwa neXRD Difforment; Zvivakwa zveHPMC Mvura yeHPMC Liting Firimu yakaedzwa uye yakaongororwa neyekuita micro-Electnic Universil Teilling Machine, uye zvinhu zveHPMC Nguva yekundyepedzera mumvura (mvura yekunyura kwemvura) inoshandiswa kuongorora iyo mvura yekunyora. Mhedzisiro inotevera inokweverwa kubva mukutsvakurudza pamusoro apa:

1) Zvivakwa zveHPMC Films kutanga uyezve zvakadzikira nekuwedzera kwekusangana kwemhinduro yemufirimu, uye kutanga kwakawedzera uye nekuwedzera kwekuwedzera kwefirimu. Kana iko kusarudzika kweiyo HPMC firimu-yekugadzira firimu yaive 5% uye iyo firimu-yekugadzira tembiricha yaive 50 ° C, iyo mechancal midziyo yefirimu yakanaka. Panguva ino, simba rakafanana rinenge ra19mpa, uye elongation pakuzorora ndeye 31%;

2) Iyo Optical Properties yeHPMC Filmy inoderera nekuwedzera kwekusangana kwemhinduro yemufirimu-inogadzira firimu, uye zvishoma nezvishoma kuwedzera kwekuwedzera kwefirimu. Inonzwisisika funga kuti kusunganidzwa kwemhinduro yemufirimu hakufanirwe kupfuura 5%, uye iyo firimu-yekugadzira tembiricha haifanire kupfuura makumi mashanu ° C

3. Kana iko kusarudzika kwe5% HPMC firimu-inogadzira firimu uye iyo firimu-yekugadzira tembiricha ye50 ° C yakashandiswa, iyo nguva yekunyungudika yemvura yaive 55 min.

CHITSAUKO 3 ZVINOGONESESA PANOPANDA paHPMC Mvura-Yakadzika PaChigina Mafirimu

3.1 Nhanganyaya

Semhando idzva yerudzi rwechisikigo Polymer Hpmc mvura-soluble paipikicha firimu ine tariro yakanaka yekuvandudza. Hydroxypruppropyl methylcellose inzvimbo yakasikwa cellulose inobviswa. Haisi yehupfu, isina-kusvibisa, inovandudza, yakagadzikana chemakemikari, uye ine zvivakwa zvakanaka. Mvura-inonaka uye yemafirimu-fomu, iyo ingangoita mvura-inokatyamadza yekuvhora mafirimu.

Chitsauko chakapfuura chakakurukura kugadziriswa kweHPMC-soluxporating firimu nekushandisa hydroxypropyl methylcellose performance kukanganisa. Mhedzisiro yacho inoratidza kuti kusimba kweiyo firimu kunenge kwa116mpa uye elongation pakuzorora ndeye 31% pasi pekodhi yekusangana uye mamiriro ekugadzirisa. Kuoma kwemafirimu akadaro kune murombo mune zvimwe zvekushandisa uye zvinoda kuenderera mberi kugadzirisa.

Muchitsauko chino, hydroxyprupyl methylcellose ichiri kushandiswa seyakaisa zvinyorwa, uye iyo yemvura-yekupenya firimu yakagadzirirwa necolution casting nzira yekugadzira firimu. .

3.2 Dhipatimendi Rekuedza

3.2.1 Zvigadzirwa zvekuedza uye zviridzwa

Tafura 3.1 yekuedza zvinhu uye zvakatemwa

Tafura 3.2 Zviridzwa Zviedzo uye Zvinyorwa

3.2.2 Sampula Kugadzirira

1) Kuyera: kuyera imwe huwandu hwe hydroxyprusyl methylcellose (5%) uye soritol (0,25%, 0,25%, 0.25%, 0.25%, 0.35%, 0.45%).

2) Kupararira: Wedzera iyo HydroxyprEpropyl Methylcellose Mvura yakadzama, simudza zvakajairika tembiricha uye nekudzvanywa kusvikira zvanyungudika kana sorbitol mune dzakasiyana zvidimbu zvakazara zvichiteerana. MuHydroxyPropyl methylcellose Solite Solite Solite Solite Solite Solite Solite Solite Solite Solite Solite Solite Solite Solite Solite Solite Solution Solite Solution Solite Solite Solution.

3) kugadzirwa kwefirimu Mushure mekunge iyo firimu yakaiswa mubhokisi rekuomesa rekushandisa.

3.2.3 chimiro uye kuongororwa kwekuita

3.2.3.1 Infrared yekunyora spectroscopy (ft-ir) kuongororwa

Infrared yekunyora spectroscopy (ftir) inzira ine simba yekuita kuti mapoka anoshanda arimo mune iyo molecular chimiro uye kuratidza mapoka anoshanda. Iyo infrared yekunyorwa kweiyo HPMC Packaging firimu yakayerwa uchishandisa Nicoer 5700 Fouret Shandura Infrared Spectform Spectform Bertrared neArmemolectric Corporation. Iyo yakatetepa firimu nzira yakashandiswa muedzo iyi, huwandu hwekutarisa hwaive 500-4000 cm-1, uye iyo mafirimu akaomeswa mune yekuomeswa neyekuomarara pagumi nemakumi mana emakore

3.2.3.2 WAKADZIDZA X-RAY DIFFRICTION (XD) Ongororo: Zvakafanana na 2.2.3.3.3.1

3.2.3.3 Kutsunga kweMuchina Properties

Simba reChilele uye Elongation pakuzorora kwefirimu rinoshandiswa se parameter yekutonga michina yayo michina. MaElongation pakuzorora ndeye chiyero chekutamiswa kusvika kune yekutanga kureba kana iyo firimu yaputswa, mu%. Uchishandisa Aptron (5943) Miniature Elect Universal Tensile Kuedza Machine yeMafirimu epurasitiki.

3.2.3.4 Kufunga kwezvinhu zvemagetsi: Zvakafanana na 2.2.3.3

3.2.3.5 kutsunga kwemvura solubility

Cheka 30mm Imwe neimwe yemuenzaniso yakayerwa katatu nguva uye kukosha kwepakati kwakatorwa, uye iyo yaive yaive min.

3.2.4 Kugadziriswa kwedata

Iyo yekuedza data yakagadziriswa neExcel, uye girafu yakakweverwa neyekutanga software.

3.3 Mhedzisiro uye Kukurukurirana

3.3.1 Mhedzisiro yeGlycerol uye Sorbitol pane iyo Infrared Yekutanga Spectrum yeHPMC mafirimu

(a) Glycerol (b) Sorbitol

Fig.

Infrared yekunyora spectroscopy (ftir) inzira ine simba yekuita kuti mapoka anoshanda arimo mune iyo molecular chimiro uye kuratidza mapoka anoshanda. Mufananidzo 3.1 inoratidza infrared spectra yeHPMC mafirimu ane akasiyana glycerol uye sorbitol anowedzera. Inogona kuoneka kubva kune iyo nhamba yehunhu hweSkeleton vibration Peaks yeHPMC Films iri kunyanya mumatunhu maviri: 2600 ~ 3700cm-1 na79cm-1 [57-5-59], 3418cm-1

Mabhendi ari pedyo anokonzerwa neyekutambanudza kweiyo OH Bond, 2935cm-1 ndiyo yekunyepedzera yepamusoro ye -3, 1 Iyo yekunyora yepamusoro yeiyo hydroxyl boka mune kutambanudza kwehuwandu hwekuvhunduka kweiyo tsika, 945cm-1 ndiko kudengenyeka kwekutanga kwepamusoro-ka-69]. Iyo yekunyora mapeki pa 1454CM-1, 1373CM-1, 1315CM-1, 1315CM-1 uye 9 Pashure pepfungwa, hapana mapurasitiki mutsva akaonekwa mune infrarared spectrum yefirimu, zvichiratidza kuti Hpmc haina kuchinja, kureva kupuraseta hakuna kuparadza chimiro chayo. Nekuwedzera kweGlycerol, kutambanudza kushungurudzika kwepamusoro -iyo-hpc-1 yeHPM CLEAS na 1657cm-1, jekiseni dzepfungwa dzepfungwa dzepfungwa dzepamusoro uye dzepasirese hydroxel. Nekuwedzera kweSpition kuHPMC firimu, iyo -Oo inotambanudza vibration inokwira pa 3418cm-1 isina kusvibiswa, uye yekunyora-bvisa-17cm-1 isina simba. . Shanduko idzi dzakabatanidzwa dzinokonzerwa nekukonzerwa nemhedzisiro uye intermolecular hydrogen kusungwa, izvo zvinoita kuti vashanduke neAljacent -ch3 uye -ch2 mabhendi. Nekuda kwezvidiki, kuiswa kwezvinhu zvinyoro zvinokanganisa kuumbwa kwekudyidzana kwehydrogen zvishuwo, saka simba riripi remufirimu rakapetwa rinodzikira [70].

3.3.2 Mhedzisiro yeGlycerol uye Sorbitol paXDT Patterns yeHPMC mafirimu

(a) Glycerol (b) Sorbitol

Fig.

Wide-Angle X-ray difFraction (XRD) inoongorora iyo crystalline mamiriro ezvinhu pachiyero cheMolecular. Iyo X-Ray Diffracometer yeArL / XTRA Rudzi Rwakaburitswa neTremo ArL Kambani muSwitzerland yakashandiswa pakutsunga. Mufananidzo 3.2 ndiyo iyo XD yeXD yemafirimu eHPMC ine akasiyana ezvikamu zve glycerol ne sorbitol. Nekuwedzera kweGlycerol, kusimba kweiyo difraction inokakavara pa 9.5 ° uye 20.4 ° ° ° ° °; Nekuwedzera kweSpitol, apo iyo mari yekuwedzera yaive 0.15%, iyo Fifraction Peak pa 9.4 ° Nekuenderera mberi kwekuwedzera kweSpitol, iyo fungidziro yepamusoro pesvedzero pa 9.5 Izvi zvinodaro nekuti kuwedzera kwemamolekyudhi madiki eGlycel uye sorbitol anovhiringidza kurongeka kwemanyorerwe uye anoparadza iyo yekutanga crystallures, nekudaro ichidzora crystallation yefirimu. Inogona kuoneka kubva kune iyo Glycerol ine pesvedzero yakanaka pane iyo crystallization mafirimu eHPMC uye HPMC ine yakanaka kuwirirana, nepo Sorbitol neHpmc isina kuwirirana. Kubva pane kuongorora kwechimiro kwevapurasitiki, sorbitol ine shuga kuridza mhere kwakafanana neyechinguvana, uye zvinokonzerwa nemamolekora masokisi uye cellulose mamorekuru, saka zvine simba kuCellulose crystallation.

[48].

3.3.3 Mhedzisiro yeGlycerol uye Sorbitol pane iyo Mechanical Properties yeHPMC mafirimu

Simba reChilele uye Elongation pakupera kwefirimu rinoshandiswa se paramita kuti vatonge midziyo yayo yekugadzira, uye kuyerwa kwezvinhu zvimiro zvinogona kutonga mashandisiro ayo mune mamwe minda. Mufananidzo 3.3 unoratidza shanduko mune yakajeka simba uye elongation pakupera kweHPMC mafirimu mushure mekuwedzera mapurasitiki.

Fig.3.3 Mhedzisiro yeGlycerol kana Sorbitolumon pane michero yezvivakwa zveHPMC mafirimu

Zvinogona kuoneka kubva kuMafutari 3.3 MaElongation pakupera kweHPMC firimu kutanga uye nekudzikira, nekuti Glycerol ane mamwe mapoka ehydrophilic, ayo anogadzira mauto ane hydration yakasimba (71], nekuvandudza kushanduka kwefirimu. Nekuwedzera kwekuwedzera kweGlycerol yekuwedzera, elongation pakupera kweHPMC firimu, uye iyo glycrol yeMacRomolecular Comment Command Chikonzero chekudzikira kwesimba kwetsile ndewekuti: Kuwedzera kwemamolekyudhi madiki eGlycul inovhiringidza urongwa hwepedyo pakati peiyo hpmc. Simba reChile rinowedzera zvishoma, kubva pamaonero embecular ketari, vakakodzera glycalar vanowedzera kuchinjika nemaketani eHPMC. Nekudaro, kana paine kakawanda glycerol, mareka yemanyorerwo ari de-akawandisa panguva imwe chete seyakarongeka kupfuura iyo yeiyo firimu, inokonzeresa iyo yakaderera simba remafirimu eHPMC. Sezvo kusimbisa kwemhedzisiro ndeyekubhadhara kweiyo tensile simba reiyo HPMC firimu, huwandu hweGlycrol zvakawedzerwa hazvifanirwe kuve zvakawandisa.

Sezvinoratidzwa mumufananidzo 3.3 (B), nekuwedzera kweSpitol, elongation pakuzorora kweHPMC firimu kutanga uye yakabva yadzikira. Kana huwandu hwe sorbitol hwaive 0.15%, elongation pakupera kweHPMC firimu yakasvika makumi mana neshanu muzana, uyezve pakuzorora kwefirimu zvishoma nezvishoma yakadzikira zvakare. Simba resimba rinodzikira nekukurumidza, uye obva rapfekera kutenderera 50mp nekuenderera mberi kwekuwedzera kweServices. Zvinogona kuoneka kuti kana huwandu hwe sorbitol hwakawedzerwa ndeye 0,15%, iyo plastictizing maitiro akanakisa. Izvi zvinodaro nekuti kuwedzera kwemasekisi madiki ehurongwa hwekuronga kwemanyorerwo, kuita kuti mhandu dzakapetwa, uye ma molekycuces ari nyore kutsvedza, saka elongation yefirimu inowedzera uye kusimba kwesimba kuderera. Sezvo huwandu hweSarudzo hwakaramba uchiwedzera, eongation pakupera kwefirimu rakadzikira zvakare, nekuti mamorekuru vedzidziso dzakazara pakati pemapepa emasangano pakati peMacRomolecules uye kuderera kweiyo elong

Kufananidza kupokana kwemhedzisiro ye glycerol uye sorbitol paHPMC mafirimu, kuwedzera 0.15% glycerol kunogona kuwedzera kuwanda pakuzorora kwefirimu kusvika pa50%; Paunenge uchiwedzera 0.15% sorbitol inogona kungowedzera macleation pakuzorora kwefirimu chiyero chinosvika makumi mana muzana. Simba rakadzikira, uye kuderera kwacho kwaive kushoma apo Glycrol akawedzerwa. Inogona kuoneka kuti kupurasitiki mhedzisiro yeGlycerol paHPMC firimu iri nani pane iro reSorbitol.

3.3.4 Mhedzisiro yeGlycerol uye Sorbitol pane iyo Optical Properties yeHPMC mafirimu

(a) Glycerol (b) Sorbitol

Fig.3.4 Mhedzisiro yeGlycerol kana Sorbitolumon Optical Property yeHPMC Films

Chiedza chinoputika uye haze zvakakosha parameter eiyo transcapency yefirimu rekutakura. Iko kuoneka uye kujekesa kwezvinhu zvakarongedzwa zvinonyanya kutsamira pachiedza chinoputika uye hazazi yefirimu rekutakura. Sezvinoratidzwa mumufananidzo 3.4, kuwedzera kweGlycerol uye Sorbitol zvese zvakakanganisa zvimiro zvemitambo zveHPMC mafirimu, kunyanya haze. Mufananidzo 3.4 (a) girafu iri kuratidza mhedzisiro yeGlycerol yekuwedzera pane iyo Optical Properties yeHPMC mafirimu eHPMC. Nekuwedzera kweGlycerol, iyo kuendesa mafirimu eHPMC yakatanga kuwedzerwa uye yakabva yadzikira, inosvika pakukosora huwandu kutenderera 0.25%; Iyo haze yakawedzera nekukurumidza uyezve zvishoma nezvishoma. Zvinogona kuoneka kubva kumusoro kuti kana huwandu hwekuwedzera kweGlycerol iri 0.25%, iyo Optical Properties yefirimu iri nani, saka huwandu hweGlycerol hachifanirwe kupfuura 0.25%. Mufananidzo 3.4 (B) girafu rinoratidza mhedzisiro ye sorbitol yekuwedzera pane iyo Optical Properties yeHPMC mafirimu eHPMC. Inogona kuoneka kubva kune iyo iyo yekuwedzera kweSpitol, iyo HPMC mafirimu eHPMC inowedzera kutanga, obva adzikira zvishoma nezvishoma uye inowedzera, uye inowedzera inowedzera kutanga uye wozowedzera. Yakadzingwa, uye chiedza chinoputika uye haze chakabuda pamusoro pemepu panguva imwe chete kana huwandu hwe sorbitol hwaive 045%. Zvinogona kuoneka kuti kana huwandu hwe sorbitol hwakawedzerwa riri pakati pe 0.35 uye45%, zvivakwa zvaro zviri nani. Kuenzanisa mhedzisiro yeGlycerol uye Sorbitol pane iyo Optical Profirties mafirimu eHPMC, inogona kuonekwa kuti sorbitol ine chekuita nezvinhu zvemafirimu.

Kazhinji zvinotaura, zvigadzirwa zvine mwenje wepamusoro ruchave neyakaderera haze, uye zvinopesana, asi izvi hazvisi zvakadaro. Zvimwe zvigadzirwa zvine mwenje wakakwira Iyo firimu yakagadzirirwa mune ino kuedza inogona kusarudza iyo yakakodzera plasticzezer uye kuwedzera huwandu maererano nezvinodiwa.

3.3.5 Mhedzisiro yeGlycerol uye Sorbitol pane iyo mvura solubility yeHPMC mafirimu

(a) Glycerol (b) Sorbitol

Fig.3.5 Mhedzisiro yeGlycerol kana Sorbitolumon mvura solubil yeHPMC mafirimu

Mufananidzo 3.5 unoratidza mhedzisiro yeGlycerol uye Sorbitol pane iyo mvura solubil yemafirimu eHPMC. Inogona kuoneka kubva kune iyo yekuwedzera kweiyo plasticzer yemukati, iyo nguva yemvura nguva yeHPMC yeHPMC inoderera, uye glycerol ine simba rakakura pane iyo solubc yemvura yeHPMC firimu pane sorbitol. Chikonzero nei hydroxyprupyl methylcellose chine yakanaka mvura solubility ndeyekuti kuvepo kwehuwandu hukuru hwemapoka ehydroxyl mumarara ayo. Kubva pakuongororwa kweiyo infrared spectrum, inogona kuoneka kuti nekuwedzera kweGlyculs neye hpmc mauto anoderera uye iyo hydrophilic Boka rinodzikira, saka solubhiliti yemvura yeHPMC firimu rinoderera.

3.4 zvikamu zvechitsauko chino

Kuburikidza neyekuita kwekuita kweHPMC mafirimu, zvinogona kuoneka kuti mapurasitiki eGlyceld uye Sorbitol anovandudza midziyo yemafirimu eHPMC uye kuwedzera elongation pakuzorora kwemafirimu. Kana kuwedzera kweGlycerol iri 0.15%, iyo manhamba emakeya mafirimu eHPMC anayo yakanaka, simba reCendele rinenge 60mpa, uye elongation pakuzorora ndeye 50%; Kana kuwedzera kweGlycerol iri 0.25%, iyo Optical Zvivakwa zviri nani. Kana izvo zvemukati zveSritol iri 0,15%, iyo SESILE Simba reHPMC firimu iri pamusoro 55mpa, uye elongation pakuzorora inowedzera kusvika pa45%. Kana izvo zvemukati zve sorbitol iri 0.45%, iyo Optical Properties yefirimu iri nani. Ose maviri epasi akaderedza zvakaderedza mvura yemafirimu eHPMC, nepo sorbitol yakanga isingakwanisi kushamisika kwemvura yeHPMC mafirimu eHPMC. Kuenzanisa kwemhedzisiro yemapurasitiki maviri pane zvivakwa zveHPMC mafirimu eHPMC anoratidza kuti kupurasitiki mhedzisiro yeGlycerol paHPMC mafirimu ari nani pane iyo yeSorbitol.

CHITSAUKO 4 ZVINHU ZVINOGONESESA VANOTAURA VANOTAURA PA HPMC Mvura-Yakadzika Mapepa Mafirimu

4.1 Nhanganyaya

HydroxyPropyl methylcellose ine yakawanda yeiyo hydroxyl mapoka uye hydroxypriropropoxoxy mapoka, saka ine yakanaka yemvura solubility. Iri pepa rinoshandisa rayo yakanaka mvura solubility yekugadzirira iyo yechokwadi girini uye zvakatipoteredza ane hushamwari-soluble paying pafirimu. Zvichienderana nekushandiswa kwefirimu remvura-svutugadzike, kuputsika kwemvura-svutugadzike yemvura kunodiwa mune akawanda mashandisirwo, asi dzimwe nguva kunonoka kudzvinyirira kunodiwawo [21].

Naizvozvo, muchitsauko chino, Glutarldehyde inoshandiswa seyekugadziridzwa kwemuchinjiko-inokatyamadza yemifananidzo yehydroxproproplose, uye pamusoro payo kuyambuka firimu kuti uderedze mvura-solubility yefirimu uye kunonoka iyo nguva yekufambisa mvura. Mhedzisiro yeGlutareldehyde vhoriyamu yekuwedzera pane iyo mvura solubility, michina yezvivakwa uye zvivakwa zvemagetsi zve hydroxyproproplose mafirimu ainyanya kudzidza.

4.2 Kuedza Chikamu

4.2.1 Zvigadzirwa zvekuedza uye zviridzwa

Tafura 4.1 yekuedza zvinhu uye zvakatemwa

4.2.2 Kugadzirira Kugadzirira

1) Kurera: kuyera imwe huwandu hwe hydroxyprusyl methylcellose (5%) ine chiyero chemagetsi;

2) Kupaza: Iyo yeiyo hydroxyprusyllSLLLLLLLELLELE inowedzerwa mvura yakagadzirirwa, uye takasiyana-siyana kusvika pakunyungudika kwenguva pfupi, mvura ine akasiyana glutarldehyde yakawedzerwa huwandu inowanikwa;

4.2.3 chimiro uye kuongororwa kwekuita

4.2.3.1 Infrared yekunyora spectroscopy (ft-ir) kuongororwa

Iyo infrared kuyamwa kweHPMC mafirimu aive akatsunga kushandisa iyo Nicoer 5700 Foureti infrared spectrared inogadzirwa neAmerican thermoelectric kambani vhara iyo spectrum.

4.2.3.2 denderedzwa X-ray diffraction (xrd) kuongororwa

Wide-Angle X-ray fidhrction (XD) ndiko kuongororwa kweiyo crystallation mamiriro echinhu pane iyo molecular level. Muro iyi, iyo crystallation mamiriro eiyo firimu yakatetepa yakanga yakatemwa uchishandisa arl / Xtra X-ray difractometer by Thermo arl yeSwitzerland. Kuyera Mamiriro ezvinhu: Iyo X-ray Source is a nickel filter cu-kwi mutsara (40 kv, 40 ma). Scan kona kubva ku0 ° kusvika 80 ° (2θ). Scan Speed 6 ° / min.

4.2.3.3 Kufunga kwekunyora kwemvura: zvakafanana na 2.2.3.4

4.2.3.4 Kufunga kwezvinhu zvemakaniki

Uchishandisa Apstron (5943) Miniature Electrenic Universal Tensile Testing Machine, bvunzo

4.2.3.5 kutsanangurwa kwezvinhu zvekushandisa

Uchishandisa mwenje wechiedza Haze tester, sarudza muenzaniso kuti uongororwe neyekuchenesa pasi uye pasina creasmittance

4.2.4 Kugadziriswa kwedatha

Iyo data yekuedza yakagadziriswa neExcel uye yakavezwa neSoftware.

4.3 Mhedzisiro uye Kukurukurirana

4.3.1 Infrared yekunyora spectra yeGlutarldehyde-Crosslinked HPMC mafirimu

Fig.

Infrared yekunyudza kusimuka inzira ine simba nzira yekuita kuti mapoka anoshanda aive mune iyo molecular chimiro uye kuratidza mapoka anoshanda. Kuti uwedzere kunzwisiswa shanduko yehydroxpropropyl methylcellose mushure mekugadziriswa, infrared bvunzo yakaitwa pane hpmc mafirimu pamberi uye mushure mekugadziriswa. Nhamba

Iyo vibrational yekunyudza mapeseni e -Oo ari pedyo ne 3418cm-1 na 1657cm-1. Kuenzanisa iyo Crosslinked uye isina kuiswa Infrared Spect yeHPMC Films, inogona kuonana neGlutarldehtehs Broup ne118cm- Molecule yakaderedzwa, iyo yakakonzerwa nekubatanidza kuita kwemamwe mapoka ehydroxyl eHPMC uye Graldehyde boka pane glutareldehyde [74]. Uye zvakare, yakawanikwa kuti kuwedzera kweGlutarldehyde hakuna kushandura chinzvimbo chehunhu hwega hwehmc, zvichiratidza kuti kuwedzera kweGlutareldehyde hakuna kuparadza mapoka eHPMC pachayo.

4.3.2 xrd mapatani eGlutarldehyde-Crosslinked HPMC mafirimu

Nekuita X-ray fidhracction pane chimwe chinhu uye kuongorora maitiro ayo akasiyana, iyo nzira yekutsvagisa yekuwana ruzivo rwakadai sechigadzirwa kana morphology yemasumbu mukati mezvinyorwa. Mufananidzo 4.2 chinoratidza iyo XDS mapatani eHPMC mafirimu ane akasiyana Glutardehdehyde anowedzera. Nekuwedzera kweGlutarldehyde, kusimba kweiyo misqufraction mapepa eHPMC yakakomberedza 9.5 Kubatanidza-kubatanidza kuita pakati peiyo hydroxyl boka uye iyo hydroxyl boka pane hpmc molecule, uye nekudaro ichidzora kurongeka kwakarongeka kweiyo hpmc molecule.

Fig.4.2 XD yeHPMC mafirimu pasi peakasiyana Glutareldehyde zvemukati

4.3.3 Mhedzisiro yeGlutareldehyde pane iyo mvura solubility yeHPMC mafirimu

Fig.4.3 Mhedzisiro yeGlutareldehyde pane mvura solubil yeHPMC mafirimu

Kubva pamufananidzo 4.3 Mhedzisiro yeGlutaraldehyde inowedzera pane iyo Solubc Films, inogona kuoneka kuti nekuwedzera kweGlutarldehdehde dotage, iyo nguva yekugadzirisa mvura yeHPMC mafirimu eHPMC anowedzera kwenguva refu. Kubatanidza-kubatanidza maitiro kunoitika neAldehyde boka paGlutarldehyde, zvichikonzera kuderedzwa kwakakura muHydroxil Mamolecule, sollal solubcus yeiyo hpmc firimu uye kuderedza iyo solubil yemvura yeHPMC firimu.

4.3.4 Mhedzisiro yeGlutareldehyde pane mechanics Properties yeHPMC mafirimu

Fig.4.4 Mhedzisiro yeGlutaraldehyde pane Tensile Simba uye Kupwanya Kureba kweHPMC mafirimu

Kuti uongorore mhedzisiro yeGlutaraldehyde zvirimo pane zvigadzirwa zveHPMC mafirimu eHPMC, iyo Simba reSecentile uye elongation pakuzorora kwemafirimu akagadziridzwa akaedzwa. Semuenzaniso, 4.4 Iro girafu yemhedzisiro yeGlutarldehyde yekuwedzera pane yakasimba simba uye elongation pakuzorora kwefirimu. Nekuwedzera kweGlutaraldehyde, simba renzvimbo uye elongation pakupera kweHPMC mafirimu ekutanga uye akabva aderera. maitiro a. Sezvo kuyambuka-kuunganidzwa kweGlutarldehyde uye cellulose ndekwekuwedzera kuyambuka HPMC mafirimu. Nekuwedzera kwekuwedzera kweGlutareldehyde, kuunganidza-kuunganidza kuwanda kunowedzera pakati pechiitiko chekunze, icho chinoratidza kuti zvinhu zvekunze zveHPMC mafirimu akaonda kuderera macroscopically [76]]. Kubva paMufananidzo 4.4, mhedzisiro yeGlutareldehyde pane iyo manhamba eFLMS inoratidza kuti kana kuwedzera kweGlutarldehyde ndeye 0.25%, iyo mishonga yemakiromita yeHPMC mafirimu ari nani.

4.3.5 mhedzisiro yeGlutarldehyde pane iyo Optical Properties yeHPMC mafirimu

Chiedza chinoputika uye haze zvinhu zviviri zvakakosha zvekuita mapepa ekuita mafirimu ekugadzira. Iyo yakakura kutapurirana, iko zviri nani kujeka kwefirimu; Iyo Haze, inozivikanwa zvakare seruranga, inoratidza huwandu hwekushamisika hwefirimu, uye hukuru haze, zvakashata kujekesa kwefirimu. Mufananidzo 4.5 ndiyo pesvedzero yekuwedzera kwekuwedzera kweGlutareldehyde pane iyo Optical Properties yeHPMC mafirimu eHPMC. Inogona kuoneka kubva kune iyo yekuwedzera kwekuwedzera kwekuwedzera kweGlutarldehyde, iyo mwenje wechiedza kutanga zvishoma nezvishoma zvinowedzera, zvinowedzera nekukurumidza uye wozodzikira zvishoma nezvishoma; Haze yakatanga kuderera uye ikazowedzera. Kana kuwedzera kweGlutareldehyde yaive 0.25%, iyo yekufambisa yeHPMC firimu yakasvika pakukosha kwe93%, uye iyo haze yakasvika kukosha kwekukosha kwe13%. Panguva ino, kuita kwechokwadi kwaive nani. Chikonzero chekuwedzera kwezvinhu zvekushandisa ndechechiitiko chekuyambuka pakati peGlutareldehyde mamorekuru uye gadziriso yakawandisa uye yunifomu, iyo inowedzera zvinhu zveHPMC films [77-79]. Kana mumiririri wekubatanidza akawandisa, nzvimbo dzinobatanidza dzinobatanidza dzinodyarwa, dzinotsvedza pakati pemamolekyudhi ehurongwa hwakaoma, uye chidimbu cheGEL chiri nyore kuitika. Naizvozvo, zvivakwa zvemukati zveHPMC mafirimu akaderedzwa [80].

Fig.4.5 Mhedzisiro yeGlutarldehyde pane Optical Property yeHPMC mafirimu

4.4 zvikamu zvechitsauko chino

Kuburikidza nekuongororwa pamusoro apa, mhedzisiro inotevera inokweverwa:

2) Izvo zvakakodzera kuwedzera glutareldehyde mune huwandu hwe1,25% kusvika 0.44%. Kana iyo yekuwedzera huwandu hweGlutarldehyde iri 0.25%, iyo yakakwana michina yezvivakwa uye zvivakwa zvemukati zveiyo HPMC firimu iri nani; Mushure mekuvharidzirwa-kubatanidza, iyo solubility yemvura yeHPMC firimu iri kwenguva refu uye iyo solubility yemvura yakaderedzwa. Kana huwandu hwekuwedzera kweGlutarldehyde iri 0.44%, nguva yemvura inokwana kusvika pa135min.

CHITSAUKO 5 Natural Antioxidant HPMC Mvura Sholux Pacing Firimu

5.1 Nhanganyaya

Kuti uwedzere kunyorera kwehydroxypropyl methylceose firimu mune zvekudya zvekudya, uye inoshandisa mhinduro yekukanda firimu kugadzirira yakasarudzika bambooxidents ine zvidimbu zvakasiyana. Antioxidant HPMC Mvura-Slouble Paliging Firimu, funda maAsixidant zvivakwa, solubility yemvura, zvimiro zvemvura uye zvimiro zvefirimu, uye ipa hwaro hwekushandisa pakurongedza kwekudya.

5.2 Kuedza chikamu

5.2.1 Zvigadzirwa zvekuedza uye zviridzwa zvekuedza

Tab.5.1 Kuedza Zvigadzirwa uye Zvinyorwa

Tab.5.2 Kuedza Zvishandiso uye Zvinyorwa

5.2.2 fungidziro kugadzirira

Gadzirira hydroxyprusyl methylcellose mvura-yekukanda mafirimu emvura ine huwandu hwentioxidlose Solution 0.05%, 0.07%, 0.09%) ye bamboo Leaf antioxidants kune iyo cellulose film-inogadzira mhinduro, uye ramba uchimutsa

Kuti ubatanidzwe zvizere, regai timire tembiricha kwemaminitsi matatu Iwisa muchiroto chekupisa ovheni, uye uiise muvheni yekuomesa kwekushandiswa kwakazotevera mushure mekusvitsa firimu. Iyo yakagadzirirwa hydroxypropyl methylcellose mvura-solulable plating firimu yakawedzera ne bamboo Leaf Antioxidant inonzi Atob / HPMC firimu pfupi.

5.2.3 chimiro uye kuongororwa kwekuita

5.2.3.1 Infrared yekunyora spectroscopy (ft-ir) kuongororwa

Iyo infrared yekubvisa mafirimu eHPMC yakayerwa muATR modhi uchishandisa Nicoer 5700 Fouret Shandura Infrared Spectforer neTermoelectric Corporation.

5.2.3.2 denderedzwa-angle x-ray difrabection (xrd) kuyerwa: zvakafanana ne2,2.3.3.3.3.1

5.2.3.3 Kugadziriswa kweAsioxidant Properties

Kuti uregere kuyera diaxidant zvivakwa zveHPMC mafirimu eHPMC, iyo HPMC yemafirimu emahara Scavenging nzira yekuyera mwero weDPPH Mahara, kuitira kuti urege kuyerera zvisina kufanira kwemafirimu.

Kugadzirira kweDPPH Solution: Pasi pemamiriro ekupaza, Dissolve 2 mg yeDPPH mu40 ml yeEthanol sol sol sol, uye swirate kwemaminitsi mashanu kuti agadzire yunifomu. Chengetedza mufiriji (4 ° C) yekushandisa gare gare.

Achitaura nezvenzira yekuedza yeZhong Yuansheng [81], nekugadziridzwa kweA0 is a0. Kuyerwa kweKukosha: Wedzera 2 mL yeDPPH Solution kune Test Tube Solube Solution yekubatanidza, kuyera kukosha kweUV iyo UV Spectrophotomer DPPH YEMAHARA RINOGONESA Scavenging Rate Curcation nzira inoreva iyo inotevera formula,

Mu formula: A ndiko kusanzwisisika kwemuenzaniso; A0 ndiyo isina chinhu control

5.2.3.4 Kufunga kweiyo mechanical zvivakwa: zvakafanana ne2,2.3.2

5.2.3.5 kutsanangurwa kwezvinhu zvemagetsi zvivakwa

Optical Properties yakakosha zviratidzo zvehuwandu hwekujeka kwemafirimu ekutakura, kunyanya kusanganisira kuendesa uye haze yefirimu. Iko kuendesa uye haze yemafirimu akayerwa uchishandisa transmittance haze tester. Iyo yekuvhenekera mwenje uye haze yemafirimu akayerwa pamhepo tembiricha (25 ° C uye 50% RH) pane bvunzo samples neyekuedza nzvimbo uye hapana creas.

5.2.3.6 Kutsunga kwekushushikana kwemvura

Cheka 30mm Kana iyo firimu inonamira kumadziro erumukira, inoda kuyerwa zvakare, uye mhedzisiro inotorwa seavhareji yenguva katatu, iyo unit ndeye min.

5.2.4 Data Kugadzirisa

Iyo data yekuedza yakagadziriswa neExcel uye yakavezwa neSoftware.

5.3 Mhedzisiro uye kuongororwa

5.3.1 ft-ir ongororo

Fig5.1 ftir yeHPMC uye AOB / HPMC mafirimu

Mumamolecules organc, maatomu ayo anoumba makemikari zvisungo kana mapoka anoshanda ari mumamiriro ekugara achigara. Kana ma molecules organc Mufananidzo 5.1 unoratidza iyo ftir spectra yeHPMC firimu uye AOB / HPMC firimu. Kubva kuVhidhiyo 5, inogona kuonekwa kuti hunhu hwechiratidzo che hydroxypruslpropyl methylcellose chinonyanya kutaurwa mu2600 ~ Iyo yakasimba vibration frequency mune 950-1250 cm-1 dunhu inonyanya kuzivikanwa nzvimbo yeCo Skeleton inotambanudza vibration. Bhandi reHPMC Firimu padhuze ne1318 CM-1 rakakonzerwa neyekutambanudza kweiyo HydroxyPropropopopoxocropopopoxocs Iyo yekunyora mapundu pa 1454CM-1, 1373CM-1, 1315cm-1, 1345cm-1 uye 9 HPMC yakagadziridzwa neAOB. Nekuwedzera kweAOB, chinzvimbo chehunhu hwega hwega cheki Iyo inotambanudzwa yeOH Bond muAgob / HPMC Firimu padyo ne1318 cm-1 inorohwa, 12]

5.3.2 xrd kuongorora

Fig.5.2 XD yeHPMC uye AOB /

Fig.5.2 XD yeHPMC uye AOB / HPMC mafirimu

Iyo Crystalline mamiriro eMafirimu akaongororwa nehurex-angle x-ray difrction. Mufananidzo 5.2 unoratidza iyo XDS mapatani eHPMC mafirimu uye AAOB / HPMC mafirimu. Inogona kuoneka kubva kune iyo nhamba iyo HPMC firimu ine 2 difFraction Peaks (9.5 °, 20.4 °). Nekuwedzera kweAOB, iyo yakasarudzika mapundu akatenderedza 9.5 ° uye 20.4 ° Kugona kwakadzikira, zvichiratidza kuti kuwedzera kweAOB kwakakanganisika kurongwa kwehydroxproplesel

5.3.3 Antioxidant Properties

Kuti uongorore mhedzisiro yeiyo AOB yekuwedzera pane oxidation kupokana neAOB / mafirimu ane zvikamu zvakasiyana zveAOB (0,03%, 0.07%, 0.09%) yakafemerwa, zvichiteererwa. Mhedzisiro yeiyo yakakwenenzvera chiyero chechigadziko, mhedzisiro inoratidzwa mumufananidzo 5.3.

Fig.5.3 Mhedzisiro yeHPMC mafirimu pasi peAOB zvemukati paDPPH GOBFITION

Inogona kuoneka kubva kuMufananidzo 5.3 kuti kuwedzera kweAOB ANTIOXIDant zvakanyanya kuvandudza mwero weDPPH. Kana huwandu hwekuwedzera kweAob iri 0.03%, iyo AOB / HPMC firimu yakanyanya kuwanda yeDPPH Mahara Kana iyo AOB icent yaive 0.05% uye 0.07%, iyo DPPH yemahara Scavenging Rate yeAob / HPMC Firimu rakakwira kupfuura iro re 0.01% boka, asi rakanyanya kuderera pane iro re0,03% boka; Izvi zvinogona kunge zvakakonzerwa nekunyanyisa kweAntioxidants yeAOB yakatungamira kuAnoglomeration yeAcob Monollole uye kugoverwa mufirimu, nokudaro ichikanganisa mhedzisiro yeAntioxidant mhedzisiro yeAOB / HPMC mafirimu. Inogona kuoneka kuti iyo AOB / HPMC firimu yakagadzirirwa mukuyedza ine yakanaka anti-oxidation performance. Kana iyo yekuwedzera huwandu iri 0.03%, iyo anti-oxidation mashandiro eAOB / HPMC firimu yakasimba.

5.3.4 Solubility mvura

Kubva paMufananidzo 5.4, mhedzisiro yeBamboo Leaf Orixidants paHydroxproplose Mafirimu, inogona kuonekwa kuti yakasiyana yeAob yekuwedzera ine kukosha kweHPMC mafirimu eHPMC. Mushure mekuwedzera AOB, nekuwedzera kwehuwandu hweAOB, iyo nguva yekunyura kwemvura yaive ipfupi, zvichiratidza kuti mvura-solubility yeAOB / HPMC firimu yaive nani. Ndiko kuti, kuwedzera kweAOB kunovandudza iyo AOB / HPMC yemvura solubility yefirimu. Kubva pane yekare XD kuongororwa, inogona kuonekwa kuti mushure mekuwedzera AOB, iyo HPMC firimu reAOB yekupinda, saka HPMC firimu, saka iyo AOB / HPMC firimu iri kuvandudzwa kune imwe nhanho. Solulogity yemvura yefirimu.

Fig.5.4 Mhedzisiro yeAOB pamvura inonyungudika yeHPMC mafirimu

5.3.5 michina yezvivakwa

Fig.5.5 Mhedzisiro yeAOB pane SESILE Simba uye Kupwanya Kureba kweHPMC mafirimu

Iko kushandiswa kwemidziyo yefirimu yakawedzera uye yakawanda kwazvo, uye michina yayo michina ine pesvedzero yakakura pane maitiro ebasa eMembrane-based Hotspot. Mufananidzo 5.5 unoratidza kusimba kwesimba uye elongation pakupwanya curves yeAOB / HPMC mafirimu. Inogona kuoneka kubva kune iyo nhamba iyo yakasiyana yeAob yekuwedzera ine yakanyanya mhedzisiro pazvinhu zvekugadzira mafirimu efirimu. Mushure mekuwedzera AOB, nekuwedzera kweAOB yekuwedzera, AOB / HPMC. Simba refirimu retsika rakaratidza maitiro anodzika, nepo elongation pakuzorora yakaratidza maitiro ekutanga kuwedzera uye obva aderera. Kana iyo AOB icent i 0.01%, elongation pakupera kwefirimu yakasvika pakukosha kwakanyanya kweanosvika makumi mana neshanu muzana. Mhedzisiro yeAOB pane iyo mechancal zvivakwa zveHPMC mafirimu eHPMC zviri pachena. Kubva kuXD kuongororwa, zvinogona kuoneka kuti kuwedzera kweAnioxidant AOB inoderedza Crystallinity yeAOB / HPMC firimu, nekudaro ichidzikisa simba reAOB / HPMC firimu. Kuwedzera kwekutora kwekutanga kuwedzera uyezve kuderera, nekuti AOB ine yakanaka yemvura solubility uye kuwirirana, uye chinhu chidiki cheMaurafu. Munguva yekuita kwekuenderana neHPMC, iyo yekudyidzana yemamolekyu yakasvomirwa uye iyo firimu yakanyoroveswa. Chimiro chakaomarara chinoita kuti AOB / HPMC firimu nyoro uye elongation pakuzorora kwefirimu rinowedzera; Sezvo AOB ichiramba ichiwedzera, elongation yekuzorora kweAOB / HPMC firimu muAOB / HPMC Firimu riri nyore kutyora kana iyo firimu yakamanikidzwa, kuitira kuti mafambiro aparare eAOB / HPMC firimu rinoderera.

5.3.6 Optical Properties

Fig.5.6 Mhedzisiro yeAOB pane Optical Property yeHPMC mafirimu

Mufananidzo 5.6 Iro girafu rinoratidza shanduko mukufambisa uye haze yeAOB / HPMC mafirimu. Inogona kuoneka kubva kune iyo yekuwedzera kwehuwandu hweAOB yakawedzerwa, iyo kuendesa kweiyo AOB / HPMC firimu inoderera uye iyo Haze inowedzera. Kana iyo AOB yezvikamu isina kupfuura 0.05%, iyo shanduko yekuchinja yechiedza chinoputika uye haze yeAOB / HPMC mafirimu akaderera; Kana iyo AOB yezvikamu zvakapfuura 0.05%, iyo shanduko yekuchinja yekufambisa kwechiedza uye haze yakakurumidza. Naizvozvo, huwandu hweAOB yakawedzerwa haifanire kupfuura 0.05%.

5.4 zvikamu zvechitsauko chino

Kutora bamboo shizha antioxidant (AOB) seyakasikwa antioxidant uye hpmc) seyakagadzirwa metrix kurongedza firimu yakagadzirirwa nemhinduro kusanganisa nekukanda firimu nzira yekugadzira firimu. Iyo AOB / HPMC yemvura-svutugadzike-yekukanda mapepa firimu yakagadzirirwa mune ino kuedza ine iyo inoshanda zvinhu zveanti-oxidation. Iyo AOB / HPMC firimu ne 0.03% AOB ine chiyero chekusimbisa che89% yeDPPH Mahara Radicals, uye Kubudirira Kubudirira ndiko kwakanyanya, izvo zviri nani pane izvo pasina AOB. Iyo HPMC firimu pa61% yakagadziridzwa. Iyo solubility yemvura yakanyanya kuvandudzika, uye zvigadzirwa zvemakhinji uye zvivakwa zvemukati zvakadzikira. Iyo yakavandudzwa oxidation kuramba yeAOB / HPMC yemafirimu emidziyo yakawedzera kushandiswa kwayo mukudya kwekudya.

Chitsauko VI Mhedziso

1) Nekuwedzera kweiyo HPMC firimu-inogadzira mhinduro yekusimbisa, iyo mechancal midziyo yefirimu yakatanga kuwedzera uye yakabva yadzikira. Kana iyo HPMC firimu-inogadzira mhinduro yekusimbisa yaive 5%, iyo michina yemuchina yeiyo HPMC firimu yaive nani, uye Simba reSimba raive riri 116mpa. MaElongation pakuzorora ndeye kanenge 31%; Iyo Optical Properties uye Solubility yemvura kuderera.

2) Nekuwedzera kwefirimu kuumba tembiricha, izvo zvimedu zvekushambadzira kwemafirimu akatanga kuwedzera uyezve zvakadzikira, zvivakwa zvemukati zvakavandudzwa, uye iyo solubility yemvura yakadzikira. Kana iyo firimu-inogadzira tembiricha ndeyekuita 50 ° C, iyo perkuita iri nani, iyo Simba reChiedza

3) Uchishandisa mapurasitiki kuti uvandudze kuomarara kwemafirimu eHPMC, nekuwedzera kweGlycerol, elongation pakupera kwemafirimu HPMC yakawedzera zvakanyanya, nepo simba rakaderera rakadzikira. Kana huwandu hweGlycrol yakawedzerwa yaive pakati pe0.15% uye 0.25%, iyo elongation pakupera kweHPMC firimu yaive anenge 50%, uye Simba reSimba raive rinenge 60mpa.

4) Nekuwedzera kweSpitol, elongation pakuzorora kwefirimu inowedzera kutanga uyezve kuderera. Kana kuwedzera kweSangano kuri kweanenge 0.15%, ma elongation pakuzorora anosvika 45% uye kusimba kwesimba kune anenge 55mpa.

5) Kuwedzerwa kwevapurasitiki maviri, Glycerol ne Spirel, zvese zvakadzvanywa zvimiro zvemvura uye solubility yemvura yeHPMC mafirimu, uye kuderera kwacho kwaive kusiri kukuru. Kufananidza kupokana kwemapurasitiki maviri pamafirimu eHPMC, zvinogona kuoneka kuti kupurasitiki mhedzisiro yeGlycerol iri nani pane iyo yeSorbitol.

6) Kuburikidza neInfrared Kuwedzera Spectroscopy (ftir) uye nehurefu-kona x-ray difrabection kuongororwa, kuunganidza kweGlutarldehyde uye HPMC uye Crystallinity mushure mekuunganidzwa-kuunganidzwa kwakadzidzwa. Nekuwedzera kweiyo mambiringa-inobatanidza mumiririri Glutaraldehyde, kusimba kwesimba uye elongation pakuzorora kwemafirimu eHPMC akatanga kuwedzera uye akabva aderera. Kana kuwedzera kweGlutarldehyde ndeye 0.25%, iyo yakazara michina yekugadzira mafirimu eHPMC ari nani; Mushure mekubatana, nguva yekunyura kwemvura inogara kwenguva refu, uye iyo-solubility inoderera. Kana kuwedzera kweGlutareldehyde iri 0.44%, nguva yekuSeto-solubility inosvika pamakore 135min.

7. Iyo AOB / HPMC firimu ne 0.03% AOB yakawedzerwa 0.03% AOB yekunyora DPPH MAHARA Iyo solubility yemvura yakanyanya kuvandudzika, uye zvigadzirwa zvemakhinji uye zvivakwa zvemukati zvakadzikira. Kana iyo yekuwedzera ye 0.03% AOB, anti-oxidation mhedzisiro yeiyo firimu yakanaka, uye iyo HPMC firimu inowedzera kushandiswa kweiyi nzira yekuisa yemufirimu mune zvekudya zvekudya.

Kutumira Nguva: Sep-29-2022

Kugadzirira uye zvivakwa zve hydroxyprupyl methylcellose