1. Izvo zvakakosha zvivakwa zveHPMC
HyproMellose, Chirungu Zita HydroxyPropyl Methylcellose, Acias HPMC. Yayo molecular formula is c8h15o8- (C10HL8O6) N-c8hl5o8, uye chigadzirwa chayo chiri chechigadzirwa cheMile. Inogona kugadzirwa nenzira mbiri: Imwe ndeyekuti giredhi rakakodzera re methyl cellelose rinobatwa na narah, uye ndokuita neiyo profilyxe oxide pasi pekushisa kwakanyanya uye kumanikidzwa. Fomu rakabatana neiyo Anhydroglucose mhete yemheremello, uye inogona kusvika iyo yakakodzera nhanho; Imwe ndeyekurapa yekoter linter kana huni propiti fiber ine caustic soda, uye ita methyl chloride uye propyle oda zvine mutsindo kuti uzviwane, uyezve nekupwanywa kuti uite zvakanaka uye yunifomu hupfu kana granules. HPMC ndeye akasiyana-siyana echisikigo chirimwa Cellulose, uye zvakare iri yakanaka mishonga yekuenzanisa, iyo ine huwandu hwakawanda hwezvinyorwa. Parizvino, inoshandiswa zvakanyanya pamba uye kune imwe nyika, uye ndeimwe yemishonga yemishonga ine huwandu hwepamusoro hwekushandisa mumishonga yemuromo.
Ichi chigadzirwa chakachena kune Milky White muvara, isina-chepfu uye isina njere, uye iri muchimiro chegakava kana fibrous poda inoyerera nyore. Iyo yakagadzikana pakuratidzwa kwechiedza uye humidyity. Inochekera mumvura inotonhora kuti iite Milky White Solution Solution, iyo ine mwero wewisikopo, uye chiitiko cheSol-gel-gel kusabatana zvinogona kuitika nekuda kwekushandurwa kwekushisa kwemhinduro. Izvo zvinonyangadza kwazvo mumakumi manomwe muzana doro kana dimethyl ketone, uye hainganyungunuke mu doro chairo, chloroform kana ethoxyethane.
Kana iyo ph ye hyprobollose iri pakati pe40 ne8,0, ine chimiro chakanaka, uye inogona kuvapo zvine simba kana ph iri pakati pe3,0 uye 11.0. Kana tembiricha iri makumi maviri ° C uye humi yehukama ndeye 80%, inochengeterwa kwemazuva gumi. Iyo yakanyorova yekunyorova inoenderana neHPMC iri 6.2%.
Nekuda kwezvakaringana zvemukati merxy uye hydroxypruppropyl muchimiro cheHyprollose, mhando dzakasiyana dzezvigadzirwa dzakaonekwa. Mune zvakananga, mhando dzakasiyana-siyana dzezvigadzirwa zvine hukuru hwehuwandu uye zvekupisa zvehondo dzegungwa, saka, zvine zvivakwa zvakasiyana uye zvinogona kushandiswa zvakaringana. The Fharmacooe nyika dzakasiyana siyana vane mitemo dzakasiyana uye mamiririri emhando: MaEuropean Pharmacoeia, madhigirii ekutsiva mumusika, anomiririrwa nemakiromita pamwe nenhamba, uye iyo unit ndeye masaga; in the United States Pharmacopoeia, the common name Add 4 digits at the end to indicate the content and type of each substituent of hypromellose, such as hypromellose 2208, the first two digits represent the approximate percentage of methoxy, and the last two digits represent hydroxypropyl Approximate percentage of .
2. Iyo nzira yekunyungudutsa hpmc mumvura
2.1 inopisa mvura nzira
Sezvo hyplomplelose haina kunyungudika mumvura inopisa, inogona kuparadzaniswa mumvura inopisa pakutanga, uye wobva wapora. Nzira mbiri dzakajairika dzinotsanangurwa seinotevera:
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(2) Wedzera 1/3 kana 2/3 yehuwandu hunodiwa hwemvura uye nekuzvipisa kusvika 70
2.2 powder kusanganisa nzira
Iyo powder zvidimbu zvakazara nekuomeswa kusanganisa pamwe neakaenzana kana yakakura huwandu hweimwe poda syredients, ndokuzonyungudika mumvura. Panguva ino, hyproomllose inogona kunyungudutswa pasina anounganidzwa.
3. Zvakanakira HPMC
3.1 inotonhora mvura solubility
Nyorovera mumvura inotonhora pazasi 40 ° C kana 70% ethanol, kunyanya kushayiwa nemvura inopisa pamusoro pe60 ° C, asi inogona kugomera.
3.2 Chemical Inertness
Hyplomllose (HPMC) rudzi rwe isiri-ionic cellulose ether. Mhinduro yacho haina iyo Ionic mhosva uye haina kupindirana nesimbi simbi kana ionic organic compos. Naizvozvo, mamwe maExccivients haaite nazvo panguva yekugadzirira maitiro.
3.3 Kugadzikana
Iyo yakagadzikana kune acid naAlkali, uye inogona kuchengetwa kwenguva yakareba pakati ph 3 uye 1l isina shanduko iri pachena muViscosity. Solution mhinduro yeHyprollose (HPMC) ine anti-nyoro-nyoro mhedzisiro uye inogona kuchengetedza yakanaka viscosity kugadzikana panguva yekuchengetedza kwenguva refu. Pharmaceuticals uchishandisa HPMC seyenzive zvine hunyanzvi hwekugadzikana pane izvo zvinoshandiswa zvechinyakare zvakanaka (senge dextrin, starch, nezvimwewo).
3.4 Kuwedzeredzwa Kweviscossity
Yakasiyana viscosity inobva yeHPMC inogona kusanganiswa zvinoenderana nemaronda akasiyana, uye viscosity yayo inogona kuchinja zvichienderana nemamwe mitemo, uye ine hukama hwakanaka hwehukama, saka chiyero chinogona kusarudzwa maererano nezvinodiwa.
3.5 metabolic inertiya
HPMC haina kunyudzwa kana metabolized mumuviri, uye haipe kupisa, saka ndiyo yakachengeteka mishonga gadziriro yekugadzirira.
3.6 kuchengetedzwa
Izvo zvinowanzotenda kuti HPMC ndeye isiri-ine chepfu uye isiri-inotsamwisa zvinhu. Iyo yepakati lethal demo yemakonzo ndeye 5g / kg, uye iyo yepakati lethal dhihwe nemakonzo ari 5.2G / kg. Deses Deses Hauna Kukuvadza Kune Vanhu.
4. Kushandiswa kweHPMC mukugadzirira
4.1 Sezvo firimu inobatanidza zvinhu uye firimu-kugadzira zvinhu
Uchishandisa HyproMellose (HPMC) Sezvo iyo firimu-yakajairwa piritsi dzemabhurandi dzakabatanidzwa, asi kuomarara, kuomesa, kufungidzira uremu uye zvimwe zviratidzo zvemhando yepamusoro zviri nani. Iyo yakaderera-vcosity grade yechigadzirwa ichi inoshandiswa seyemafirimu-solux yefirimu yekuvhara zvinhu zvemahwendefa nemapiritsi, uye giredhi repamusoro rinoshandiswa seyakagadzirwa firimu zvinyorwa zve organic system. Iyo yekuvhara inowanzoitika 2.0% kusvika 20%.
4.2 sekubhuka uye kuparadzanisa
Iyo yakaderera-vcosity grade yechigadzirwa ichi inogona kushandiswa seyekuchinjika uye kupaza mapiritsi, mapiritsi, uye giredhi repamusoro, uye giredhi repamusoro, uye giredhi repamusoro rinogona kushandiswa chete seinongoshandiswa. Iyo Dosage inosiyana nemhando dzakasiyana uye zvinodiwa. Kazhinji, iyo dosage yeBinder yehwendefa dzakaoma mahwendefa ndeye 5%, uye dosage yeBinder yeaiplate mahwendefa egirini iri 2%.
4.3 seMumiriri Anomhanya
Iyo yekumisikidza mumiririri ndeye viscous gel chinhu ne hydrophilikuticity, iyo inogona kudzora kumhanya kwekumhanya kwezvidimbu kana ichishandiswa kune iyo masisitimu ekudzivirira zvidimbu kubva mukukasira uye kuderera kuita bhora. Kumisa vamiririri vanoita basa rakakosha mukuita kumiswa. Hpmc akasiyana-siyana vamiririri vanomisa, uye isarudzo yayo yekunyungudika inogona kuderedza kusawirirana kwemvura-yakasimba interface uye yakasununguka simba pane zvidiki zvakasikwa, nekukasira kugadzikana kweiyo heteroxious system. Iyo yakakwira-vcosity grade yechigadzirwa ichi inoshandiswa seyekumiswa-mhando yekugadzirira kwemvura yakagadzirirwa seyemumiriri kumisikidza. Iyo ine maitiro akanaka ekutanga, ari nyore kutsausa, haanamatire kumadziro, uye ane zvimedu zvakanaka zvidimbu. Iyo yakajairwa dosage ndeye 0.5% kusvika 1.5%.
4.4 Senge blocker, inotsigira-kuburitswa mumiriri uye pore-kukonzera mumiririri
Iyo yakakwira-viscosity grade yechigadzirwa ichi inoshandiswa kugadzirira hydrophilic gel mahwendefa akasimbisa Yayo yekushandisa yekushandisa ndeye 10% ~ 80% (w / w). Low-viscosity mamakisi anoshandiswa sevamiriri-ekuumba vamiririri vekusunungurwa-kusunungura kana kudzorwa-kudzora gadziriro. Iyo yekutanga dosi inoda kuti kurapa kwemhedzisiro yemhando iyi yerwendefa kunogona kuwanikwa nekukurumidza, uyezve kusunungura-kusunungurwa-kusunungurwa-kusunungurwa-kweropa kusimbisa zvinoitwa mumuviri. Kana hyproomllose inosangana nemvura, iyo hydrates yekuumba gel layer. Iyo Mechanism yekuburitswa kwezvinodhaka kubva kune iyo matrix piritsi inonyanya kusanganisira kusiyana kweiyo gel layer uye kugumisa kweiyo gel layer.
4.5 inodzivirira glue se thickener uye colloid
Kana ichi chigadzirwa chinoshandiswa seanoti, iyo inowanzoshandiswa kushanduka ndeye 0.45% ~ 1.0%. Ichi chigadzirwa chinogona zvakare kuwedzera kugadzikana kwehydrophobic glue, dzivirira midziyo yekudzivirira kubva pakuwedzera uye agglomication, nekudaro ichindimisa kuumbwa kweSediment, uye yayo yakajairwa ndeye 0.5% ~ 1.5%.
4.6 Capsule Chinyorwa cheCapules
Kazhinji kopsule shell capsule zvinyorwa zve capsule yakavakirwa paGelatin. Maitiro ekugadzira eGelatin Capsule shell iri nyore, asi kune mamwe matambudziko uye zviitiko zvakashata zvinodhaka uye mishonga yakadzika uye yakanonoka kuparadzaniswa kwemakapu yekapu panguva yekuchengetedza. Naizvozvo, hypromellose, sechinhu chinotsiva maGelatin capsules, chinoshandiswa mukugadzirira makapu, chinovandudza kuumbwa uye kushandisa mhedzisiro yemakapu, uye yakakurudzirwa zvakanyanya kumba uye kune imwe nyika.
4.7 seBioadhesive
Bioadhesion tekinoroji, kushandiswa kweanoshandisa polyhesive polita, kuburikidza neyekuzvarwa muCoiological mucosa, anowedzera kuenderera mberi kwekutanga uye muCoosa akasunungurwa zvishoma nezvishoma uye akabatikana neiyo mucosa kuzadzisa zvinangwa zvekurapa. Izvozvi zvinoshandiswa zvakanyanya zvinoshandiswa kurapa chirwere chemhino yemhino, emuromo mucosa uye zvimwe zvikamu. Gastrointestinal Bioadhesion tekinoroji isarudzo itsva yezvinodhaka inogadzirwa mumakore achangopfuura. Izvo hazvingowedzera nguva yekugara yekugadzirira kweMishonga muGastrointestinal Turakiti, Kuchinja Kupararira kweMushonga weStentinal Epithelial Masero, nekuvandudza kushaikwa kwemushonga wemushonga.
4.8 sezvazviri zveGel
Sezvinogadzirira kugadzirira kweganda, gel ine mikana yakanakira senge kuchengeteka, runako, nyore kuchenesa, mutengo wakaderera, maitiro akareruka, uye kuenzanisa kwakanaka nemishonga. kutungamira.
Kutumira Nguva: Kukadzi-14-2025