HPMC / HPS HOT-Cold Gel Blend

HydroxyPropyl methylcellose (HPMC) firimu ine simba rakanakisa, iyo iscosity yekudziya yakanyanya kuderera, kana kuomarara pakudziya kugadzirira firimu, zvichikonzera kuita kwakashata. Mukuwedzera, mutengo wayo wakakwira unodzikamisa application yaro. Hydroxypropyl Starch (HPS) yakaderera-mutengo inotonhora Gel, inowedzera inogona kuwedzera tembiricha, uye kuenderera mberi kweiyo mapoka uye hydroxpropypropyl mapoka ese anobatsira kuenderana neaya mapolyti. Naizvozvo, chando chinotonhora-chinotonhora genend system yakagadzirirwa nekubatanidza hps uyeHpc, uye mhedzisiro yekushisa pachimiro cheHPMC / HPS inopisa-inotonhora Gel System yakarongeka yakarongeka nekushandisa rheometer uye diki canle x-ray inopararira nzira. .

Mhedzisiro yacho inoratidza kuti pakupisa kwakanyanya, gel ine yepamusoro yeModius uye zvakanyanya maitiro akasimba-shoma emaitiro eGel, uye saizi yeGel Aggregates yakakura; Pakushisa kwakadzika, iyo HPS yezvinyorwa zvakakwirira gel samples ine yepamusoro modulus, zvakanyanya mukurumbira-wakasimba-kuita maitiro, uye denser kuzvida-zvakafanana chimiro cheGel vabati. Kwemasampuli ane zvakafanana kubatanidza ratio, iyo modulus uye yakaenzana-maitiro maitiro ekuwedzera kwemasuru anotongwa neHPMC pane yakakwira tembiricha pane iyo tembiricha yakakwira kupfuura iyo HPS pakudziya kwakadzika. Tembiricha inoomeswa inogona kukanganisa iyo gel chimiro isati yaoma, uyezve inokanganisa chimiro chefirimu, zvichikonzerwa nesimba remafirimu rakaomeswa pakupisa kwakanyanya. Yakakwirira kupfuura yakaoma pane yakadzika tembiricha. Muyero wekutonhora hauna kujeka pane iyo crystalline chimiro chehurongwa, asi zvine chekuita nedzimba dze microdomain yekuzvininipisa kwefirimu. Mune ino system, density yeiyo yekuzvifunga-yakafanana yefirimu inogona kukanganisa maitiro ezvivakwa zvefirimu. Kuita kune maitiro makuru.

Zvichienderana nekugadziriswa kwemamriyano wakasanganiswa, chidzidzo chakawana kuti kushandiswa kweIodine Solution kusarudza Dhayi yeHPMC yakatarisa kugoverwa nenhamba neChikamu cheiyo yakasanganiswa system pasi pe microscope. Nzira, iyo ine nzira dzinotungamira kukosha kwekudzidza kwechikamu chekuparadzira chikamu che starch-yakavakirwa masisitimu. Uchishandisa iyi itsva nzira yekutsvagisa, yakasanganiswa neyeMafutiro microscopy uye extron hukama pakati pesimba. Iyo microscope yekuongorora mhedzisiro inoratidza kuti system iri pasi pechiitiko ichiita kana hps ratio iri 50%, uye nhare inosanganisa phenomenon iripo mufirimu, zvichiratidza kuti hurongwa hune imwe nhanho ine huwandu hwekuenderana; Infrared, errmogravimetric ongororo uye semi mhinduro dzinowedzera kuoneka kusanganisa. Iyo system ine imwe nhanho yekuenderana. Iyo modulus yeiyo yakasanganiswa firimu shanduko kana iyo HPS zvemukati iri 50%. Kana iyo HPS yezvinyorwa zvakakura kupfuura 50%, iyo kona yekubatana kweiyo yakasanganiswa semuenzaniso inotsauka kubva pamutsetse wakananga unobatanidza magiramu ekurongedza emasampuli akachena, uye kana isingasviki 50%, inodudzira zvisina kunaka kubva pane iyi yakatwasuka mutsara. , iyo inonyanya kukonzerwa nechikamu cheshanduko.