Maitiro ekunyungudutsa hydroxypruppropyl methylcellose?

Yakanyungudika hydroxypropyl methylcellose (HPMC) inoda kunzwisiswa zvaro zvivakwa uye kusarudza yakafanira sol. HPMC ndeye cellulose inobviswa zvakanyanya kushandiswa mumishonga yemishonga, chikafu, uye dzakasiyana siyana maindasitiri. Izvo zvinonyangadza mumvura asi zvine zvivakwa zvakasarudzika zveGel-fomu.

Hunhu hwe hydroxyprupyl methylcellose (HPMC):
Chemical dhizaini:
HPMC ndeye semi-synthetic yemvura-soluble polymer inotorwa kubva ku cellulose. Iyo ine zvikamu zviviri zvikuru:
Cellulose backbone: inopa kutendeka kwechimiro.
Hydroxypruppropyl uye methyl substituets: alter salubility uye rheological zvivakwa.

Solubility:
HPMC inoratidzira yakasimba salubility mumvura, kugadzira yakajeka uye viscous mhinduro. Nekudaro, iyo yekunyungudika chiyero inogona kusiyana zvichienderana nezvinhu zvakadai sekupisa, HPMC giredhi, uye kuvapo kweimwe zvinhu.

Gel kugadzira zvivakwa:
Kuwedzera pakuve polymer inosemesa, HPMC inogona zvakare kuumba matanda pamberi pevamwe ion kana kuburikidza nekudziya-kupembera glation. Ichi chivakwa chakanyanya kutsoropodza mumishonga yemishonga uye zvekudya zvekudya.

Zvinhu zvinokanganisa HPMC DISSOLULT:

tembiricha.
Kazhinji, kupisa kwakanyanya kunowedzera huwandu hwekunyungudika hweHPMC. Nekudaro, kupisa kwakanyanya kunogona kukonzera glation, kukanganisa mhinduro kuita.

Ph:
HPMC yakagadzikana pamusoro peyakafara pH range. Nekudaro, acidic kana alkaline mamiriro anogona kukanganisa kupaza kwayo. Muzviitiko zvakawanda, kusarerekera kana zvishoma alkaline ph kunodiwa kuputswa kwakakwana.

Polymer Giredhi:
Mavara akasiyana eHPMC ane akasiyana ma molecular maseru uye kutsiva mazinga, kukanganisa maitiro avo. Yakaderera molecular uremu mamakisi anowanzo nyungudika nekukurumidza.

Saizi yechikuru:
Kuderedza saizi yehukuru yeHPMC inowedzera nzvimbo yemusoro inowanikwa yekupararira, nekumhanyisa maitiro.

Kuvapo kwemunyu:
Mamwe munyu wemamwe, senge sodium chloride, anogona kukanganisa hpmc kupaza. Ivo vanogona kusimudzira kana kukanganisa maitiro, zvichienderana nemamiriro ezvinhu.

Solventats yekunyungudika HPMC:
mvura:
HpMC inonyanya kuve solugle mumvura, inogadzira mhinduro yakajeka, viscous. Iyo mwero wekunyungudutswa inokanganiswa nekudziya kwemvura uye hpmc kusungwa.

Organic sol soles:
Kunyangwe HPMC inowanzoonekwa semvura-solullo, mamwe mamakisi anogona kuve akanyura mune mamwe organc sol solhanol kana methanol. Nekudaro, kushandiswa kweiyo organic solses kunogona kukanganisa kuchengetedza kwezvakatipoteredza uye kuchengetedzeka kwemaitiro.

HpMc Dissolution Nzira:
1. Kutonhora kwemvura kupararira:
Zvishoma nezvishoma wedzera hpmc kumvura inotonhora ichimutsa nguva dzose.
Rega musanganiswa hydrate kwemaawa mashoma kana husiku humwe.
Kana kupaza kwakazara kunodiwa, wedzera tembiricha.
2. Nyungudusa mumvura inopisa:
Nyungudika hpmc mumvura inopisa ichimutsa nguva dzose.
Dzora tembiricha kudzivirira kuumbwa kwegumi.
Rega mhinduro inotonhorera kuti uwane yakajeka, gobvu yekuenderana.
3. Kubatanidza nevamwe vePolymers:
Kusanganisa HPMC nedzimwe poldulble polymers inogona kuvandudza iyo solubility zvivakwa.
Iyi nzira inozivikanwa mukugadzirira mishonga yemishonga.
4. Kushandiswa kweSurfaers:
Kuwedzera surfacts kunogona kusimudzira iyo yakanyorova uye kupaza HPMC.
Chenjera chinofanira kutorwa kuti uve nechokwadi chekuenderana nechinangwa chekushandisa.
5. Kudzora PH mamiriro:
Kugadzirisa iyo pH mukati meiyo yakakodzera renji inogona kuongorora kupaza kweHPMC.
Buffer Solutions inogona kushandiswa kuchengetedza iyo inodiwa ph level.

Kukurukurwa kufunga:

Zvivakwa zvekudzivirira pachako (PPP):
Pfeka michina yakakodzera yekudzivirira, kusanganisira magurovhosi uye gogo, kana uchibata HPMC uye sol sol.

Ventilation:
Ita shuwa nzvimbo yebasa yakanyatsovhurwa kuti ideredze kuratidzwa kweiyo solvent.

Kuenzanisa Kwekuenderana:
Kuenzanisa kuenzanisa nezvimwe zvinoshandiswa kuti udzivise zvakashata kutaurirana.

Kukanganisa pane zvakatipoteredza:
Funga nezvekukanganisa kwezvakatipoteredza kweiyo yako yakasarudzwa solvent uye yekurasa nzira.

Kunyungudza hydroxyprupylpropyl methylcellose kunosanganisira kunzwisisa zvivakwa zvaro, kusarudza solinen yakakodzera, uye kushandisa nzira yakakodzera. Zvinhu zvakadai sekupisa, Ph uye giredhi giredhi ramba rakakosha basa mukuwana kuparara kwakakwana. Kunyatsofungisisa nezvechengetedzo uye nyaya dzezvakatipoteredza dzinotsoropodza zvese zvese. Nekutevera nhungamiro idzi, mumwe anogona kunyatso nyungudusa hpmc kune dzakasiyana siyana dzekushandisa mumishonga yemishonga, chikafu, uye indasitiri.