Zvinotora nguva yakareba sei kuti HPMC kuti isimbe?

HPMC (HYDROXYPROPYL MetHylcellose) ishandiswe inowanzo shandiswa inoshandiswa mukugadzirira kwemahwendefa emishonga yemishonga, madonhwe eziso uye zvimwe zvigadzirwa. Nguva yayo yekunyungudika inotsamira pazvinhu zvinoverengeka, kusanganisira molecular uremu, mhinduro tembiricha, kumhanyisa kumhanya uye kusimbisa.

1. Molecular uremu uye degree rekutsiva
Iyo molecular uremu uye degree rekutsiva (kureva, methxy uye hydroxypruppropyl zvemukati) yeHPMC ichakanganisa iyo solubility. Kazhinji, iyo yakakura uremu, iyo yakareba inotora kunyungudika. Yakadzika viscosity HPMC (yakaderera molecular uremu) kazhinji inotora maminitsi makumi maviri kusvika makumi maviri ekunyungudika pamhepo tembiricha, nepo yakakwira viscosity hpmc (yakakwira molecular uremu) ingatora maawa akati wandei.

2. Mhinduro tembiricha
Tembiricha yemhinduro ine kukosha kwakakosha pakupera kwehyoko yeHPMC. Tembiricha yepamusoro dzinowanzo kumhanyisa maitiro ekupaza, asi kupisa kwakakwirira kunogona kukonzera kusvibiswa kweHPMC. Iyo inowanzo kukurudzirwa kupazwa tembiricha iri pakati pegumi 20 ° C uye 60 ° C, uye yakasarudzika sarudzo zvinoenderana nehunhu hweHPMC uye chinangwa chekushandisa.

3. Kumhanyisa kumhanya
Kukurudzira kunogona kusimudzira kuputswa kweHPMC. Kukurudzira kwakakodzera kunogona kudzivirira iyo Agglomeration uye yakatsvaira yeHPMC uye inoita kuti ive yakanyanya kupararira mumhinduro. Iko kusarudzwa kwekukurudzira kumhanyisa kunofanirwa kugadziriswa zvinoenderana nemidziyo yakatarwa uye maitiro eHPMC. Kazhinji, mhedzisiro inogutsa inogona kuwanikwa nekukurudzira kwemaminitsi makumi maviri kusvika makumi maviri.

4. Kugadzirisa Solution
Iko kusangana kweHPMC zvakare chinhu chakakosha pakutarisa nguva yayo yekunyungudika. Iyo yakakwira kusunganidzwa, iyo yakareba nguva yekunyungudika kazhinji. Kuti uwane kuderera kuderera (<2% w / w) HPMC mhinduro, nguva yekunyungudika ingave ipfupi, nepo mhinduro dzakakwirira dzinoshamisa dzinoda nguva yakawanda yekunyungudika.

5. Solvent kusarudzwa
Pamusoro pemvura, HPMC inogona zvakare kunyungudika mune mamwe mashoni akadai se ethanol uye ethylene glycol. Iyo polarity uye solubility yemamwe mashiromisi akasiyana anozokanganisa chiyero cheHPMC uye maitiro emhinduro yekupedzisira.

6. Dzidziso Dzimba Dzidziso
Dzimwe nzira dzekunyepedzera, dzakadai seyekunyorovesa hpmc kana kushandisa mvura inopisa, inogona kubatsira kukurumidza kudzvinyirira maitiro ayo. Uye zvakare, kushandiswa kwekusagadzikana kweAIDS kwakadai semafungo kunogona zvakare kuvandudza kunyatsoita kwekunyanyisa.

Nguva yekunyungudika yeHPMC inokanganiswa nezvakawanda zvinhu. Naizvozvo, mune zvinoshanda zvinoshandiswa, mamiriro ekunze anofanirwa kuchinjirwa zvinoenderana nezvakananga kushandisa zvinodiwa uye maitiro eHPMC. Kazhinji, iyo nguva inodiwa kuti HPMC yekunyungudika pasi pemamiriro ezvinhu akakodzera kubva pamaminitsi makumi matatu kusvika kumaawa akati wandei. Zvekutanga HPMC zvigadzirwa uye zviitiko zvekushandisa, zvinokurudzirwa kureva mirayiridzo yechigadzirwa kana mufambiro wekuyedza kuona mamiriro ekupazwa uye nguva.