Zvinhu zvinokanganisa HPMC DISSOLULT

Iyo Solubility yeHydroxyPropyl MetHylcellose (HPMC, HPMC, HYDROPYPLELL MetHylcellose Izvi zvinhu zvinokosha kwazvo kushandisirwa kweHPMC uye maitiro ayo mumishonga yemishonga, chikafu, kuvaka uye mamwe maindasitiri.

1. Zvepanyama uye zvemakemikari zvivakwa

1.1 Molecular uremu
Iyo smecular uremu hweHPMC chinhu chakakosha chinokanganisa iyo solubility. Kazhinji, yakakura huremu hwemanyorerwe, inononoka kudzvinyirira. Izvi zvinodaro nekuti yakakura molecular uremu mhedzisiro yemanyorerwo, iyo inowedzera kupinda uye kuwirirana pakati pemamorekuru, nekudaro ichidzora maitiro ekunyungudika. Pane zvinopesana, HPMC ine zvidiki molecular uremu hunopera nekukurumidza, asi zvavakagadziriswa viscosity inogona kunge yakaderera, ichiita kuti isasatarisirwa kune zvimwe zvinoshandiswa.

1.2 degree rekutsiva
Dhigirii rekutsiva kweHPMC (kureva kuti dhigirii rekutsiva nzira uye hydroxypriropopopoxoxy mapoka) zvakare zvinokonzeresa zvinobata. HPMC ine mwero wakakwira uye hydroxypriyo substiptopopopopocution inowanzo kuve nani solubility mumvura nekuti aya akaomeswa anokwanisa kuwedzera hydrophicity yemamorekuru uye kusimudzira hydration. Nekudaro, kunyanyisa kutsiva kunogona kutungamira mukuderera kweiyo solubility yeHPMC mune mamwe mashiromita, ayo ane hukama nehurongwa hweiyo solvent uye molecular kutaurirana.

1.3 Chikamu
Saizi yehukuru hweHPMC ine zvakananga kukanganisa pane yayo yekunyungudika chiyero. Iyo diki iyo size size, iyo yakakura nzvimbo yakanyanya pamusoro peyuniti vhoriyamu, uye nzvimbo yacho yakafumurwa kune inowedzera, nekudaro ichikurudzira maitiro ekunyungudika. Naizvozvo, hpmc mune yakanaka powder fomu inowanzo nyungudika nekukurumidza kupfuura muCoarse Granular fomu.

2. Solvent mamiriro

2.1 solvent mhando
Iyo solubility yeHPMC inosiyana kwazvo mune akasiyana sol sol. HPMC ine yakanaka solubility mumvura, kunyanya kudziya mvura. Asiri-mashoni ekusimbisa senge ethanol, procylene glycol, etclene glycol, etc.Cocc. Mune solvent musanganiswa, solubility zvinoenderana nezvakaenzana nezvikamu uye kudyidzana kwavo neHPMC.

2.2 tembiricha
Tembiricha ine kukosha kwakanyanya pane iyo solubility yeHPMC. Kazhinji, HPMC inodonha zvishoma nezvishoma mumvura inotonhora, asi sezvo tembiricha inowedzera, iyo chiyero chekunyungudika chinowedzera zvakanyanya, uye chinoita zvakanakisa mumvura inodziya ye40-50 ° c. Nekudaro, pakupisa kwakanyanya (kazhinji pamusoro pe 70 ° C), HPMC inogona kufungidzira kana kuumba gel, iyo ine chekuita neshanduko mune yayo yeiyo thermodynamic zvinhu uye mhinduro dhizaini.

2.3 PH Kukosha
Iyo solubility yeHPMC ine yakagadzikana pasi peakasiyana PH mamiriro, asi zvakanyanyisa PH mamiriro (akadai akasimba acid kana alkali) anogona kukanganisa solubility uye kugadzikana. HPMC inowanzove neyakanakisa solubility iri pasi peyakagwinya kana padyo-zvisina kwayakarerekera PP mamiriro.

3. Zvinhu zvekunze kwezvakatipoteredza

3.1 inosimudzira mamiriro
Iyo yekumhanyisa kumhanya uye nzira ine kukosha kwakakosha pakumhanya kwekunyungudika kweHPMC. Kukurudzira kwakakodzera kunogona kusimudzira kusangana pakati peHPMC uye solvent kuti udzivise kuumbwa kwemakomputa, nekudaro zvichikurudzira maitiro ekunyungudika. Kumutsa nekukurumidza kunogona kukonzera mabhuruku kuumba, kukanganisa kufanana kwemhinduro.

3.2 Kuwedzera
Zvimwe zvinopindwa mumhinduro, dzakadai semunyu, maElectrolytes, surfacts, nezvimwe, zvichakanganisa iyo solubility yeHPMC. Semuenzaniso, mamwe mapuranga anogona kusimudzira kupaza kweHPMC, nepo manyorerwo emakekiti akareba emagetsi anogona kukonzera kusarudzika kana viscosity shanduko yeHPMC. Kuwedzerwa kwevashanu vanokwanisa kuvandudza iyo solubility yeHPMC mune mamwe asiri-emvura miganhu uye optimize kuita kwemhinduro.

4. Kuongorora kwekushandisa

4.1 mishonga indasitiri
Muindasitiri yechechi, Hpmc inozoshandiswa zvakanyanya seyekugadzira matrix mukugadzirira-kusunungurwa-kusunungurwa kwakabatana, uye yayo solubility inobata zvakananga chiyero chekusunungura uye kubaya kwemushonga. Naizvozvo, kudzora huremu hwemanyorerwe, degree rekutsiva uye kupaza mamiriro eHPMC kwakakosha pakugadzirira kwekugadzirira uye kwakagadzikana mishonga gadziriso gadziriso.

4.2 Chikafu Chekudya
Muindasitiri yechikafu, HPMC inoshandiswa seanotenda, stabilizer uye emulsifier. Yayo solubility inosarudza kupararira kwayo, kuumbwa uye kugadzikana mune chikafu. Nekugadzirisa mamiriro ekunyungudika, mhedzisiro yeHPMC mune chikafu inogona kugadzirwa.

4.3 Kuvaka Endano
Muzvivakwa zvekuvaka, HPMC inoshandiswa semumiriri wekuchengetedza mvura, thickener uye binder, uye iyo solubility inokanganisa maitiro ekuvaka uye emhando yekupedzisira yemadhadha, zvigadzirwa uye zvimwe zvigadzirwa. Kugadzirisa mamiriro ekunyungudika uye nzira dzekushandisa dzeHPMC dzinogona kuvandudza kushandiswa kweshandisirwo uye kusimba kwechinyorwa.

Iyo solubility yeHPMC inokanganiswa nezvinhu zvemuviri uye zvemakemikari zvakadai semafuta, saizi yekutsiva, pamwe chete solvent mamiriro, tembiricha, uye zvinhu zvekunze zvezvakatipoteredza. Mune zvinoshanda zvinoshanda, iyo Solubility uye inoshanda yeHPMC inogona kunyatsogadziriswa nekukasira kusarudza uye kudzora zvinhu izvi zvinoenderana nezvinodiwa chaizvo uye nharaunda. Kunzwisisa kwakadzama kwezvinhu izvi kuchabatsira kuvandudza mashandiro eHPMC mumiyedhi akasiyana uye kupa rutsigiro rwehunyanzvi hwekuvandudzwa kweminda.