Hpmc inogona kupera mumvura inopisa here?

HPMC (hydroxyprEpropyl methylcellose) ishandiswe mvura-yemvura mherzuru inobviswa, inoshandiswa zvakanyanya mukuvaka, kuungana, mushonga, chikafu uye mamwe maindasitiri. Iyo inowanikwa nemakemikari kugadziridzwa kwemasikirwo cellulose. Maitiro ayo ezvekugadzira anogonesa kuumba mhinduro yepamusoro-viscosity mumvura uye ine imwe solubility.

Hpmc inogona kupera mumvura inopisa here?
HPMC inogona kunyungudika mumvura inopisa, asi maitiro ayo akanyatsorondedzera nezvinhu zvakadai sekupisa, kupisa kwemvura kwekunyungudika, smecar uremu hweHPMC, uye degree rekushandurwa. Kazhinji, HPMC inogona kunyungudika pamhepo tembiricha, asi mwero wekunyungudika uchakurumidza kupisa kupisa.

1. Dissolution Mechanism
Iyo Mechanism yeHPMC inopera mumvura inonyanya kuenderana neHydrophilikuti yeiyo hydroxyl uye methyl mapoka uye mapoka epuropa mumamolekyudhi ayo. Mamolekyudhi emvura anogona kudyidzana neHydroxyl uye methyl mapoka mune hpmc mamorekuru kuburikidza neHydrogen zvishamiso, zvekuti mapopuni cellulose maketani anosunungurwa uye pakupedzisira mhinduro yunifomu inoumbwa. Naizvozvo, HPMC ine yakanaka mvura solubility.

2. Mhedzisiro yekudzvinyirira tembiricha pane iyo solubility yeHPMC
Iyo solubility yeHPMC inowanzowedzera nekuwedzera kupisa. Pasi pemamiriro ekunze epamusoro, iyo yeKinetic simba remamolekyudhi emvura inowedzera, uye dzinogona kuwirirana nemapoka ehydrophilic muHPMC mamorekuru, nekudaro achikurudzira maitiro avo ekunyungudika. Kunyanya yeHPMC ine yakakwira molecular uremu, mvura inopisa inogona kubatsira kunyungudutsira nekukurumidza.

Nekudaro, iyo solubility yeHPMC haigone kungoenderana nekushisa, asiwo pane kwayo nzira yekuchema. Iwo akasiyana emakemikari eboka ratios muHPMC molecule anokanganisa mari yayo yekunyora uye kupaza mvura. Semuenzaniso, HPMC ine yakakwira hydroxyprupropropyl ine hydrofiromilikupikira yakasimba uye saka inodurura nekukurumidza mumvura.

3. Mhedzisiro yekupisa kwakanyanya pane yekunyungudika chiyero
Pakupisa kukuru, iyo yekunyorova yeHPMC ichave yakanyanya kukurumidza. Kunyanya, muhuwandu hwe60 ° C kusvika 90 ° C, iyo yekunyorova yeHPMC yakagadziridzwa zvakanyanya. Izvi imhaka yekuti mvura inopisa inogona kuparadza zvinobudirira kusungwa kwehydrogen pakati pemamorekuru, kubvumira mamorekuru emvura kuti ipinde mumanyorerwo eHPMC nekukurumidza, nokudaro inosimudzira kupaza kwayo.

4. Matambudziko anogona kusangana panguva yekupararira
Kunyangwe HPMC inogona kunyungudutswa mumvura inopisa, kana tembiricha yakanyanya, iyo HPMC mumhinduro inogona kuve nekushatiswa kana kushandurwa kwechimiro, kunyanya kana ichinyanya kuiswa pakupisa kwakanyanya kwenguva yakareba. Izvi zvinogona kukanganisa zviso zvaro uye basa, kunyanya mune dzimwe nzvimbo dzekushandisa, shanduko iyi inogona kunge iine mukana wekuti chigadzirwa chekupedzisira.

Kana tembiricha yemvura yakawedzerwa panguva yekunyungudika yakanyanya, HPMC poda inogona kuumba muchikamu chegglomer mumvura, zvichikonzera kuparara zvisina kukwana. Naizvozvo, kuitira kuti kuve nechokwadi chekuparadzwa kwakazara kweHPMC, zvinowanzokurudzirwa kushandisa mvura inodziya panguva yekuparadza uye kutora nzira dzakakodzera dzekukurudzira dzakabatsirwa.

Mienzaniso yekushandisa yekupisa kwemvura inopisa yeHPMC
Mune zvinoshandiswa zvinoshanda, iyo inopisa mvura solubility yeHPMC inowanzo kushandiswa. Semuenzaniso, muindasitiri yekuvaka, hpmc, seyakakosha adminture, inogona kupa yakanaka rheology, kuderedza uye nekuchengetwa kwemvura kuburikidza nekuita nemvura. Paunenge uchigadzirira simende slurry kana dhiri, hpmc inogona kubatsira kuvandudza mashandiro ekuvaka uye kudzivirira kupaza.

Muindasitiri yechechi, HPMC inoshandiswa zvakanyanya mukugadzirwa kwevamiriri vekusunungurwa-vakaburitswa uye ma capsule madhiragi ezvinodhaka. Nekuda kwekunaka kwayo kwemvura solubility, HPMC inogona kupera zvishoma nezvishoma mumuviri wemunhu uye kusunungura zvinodhaka. Mukuita uku, tembiricha yemvura uye mwero wekunyorova weHPMC tamba chakakosha.

Muindasitiri yechikafu, hpmc, sechikafu chinowedzera, chinowanzoshandiswa seyekudya, emulsifier, etc. Mushure mekunyungudika mumvura inopisa, inogona kupa viscosity yaunoda uye kuumbwa, kuvandudza kuravira uye kugadzikana kwechikafu.

HPMC inogona kunyungudutswa mumvura inopisa, uye iyo solubility ine tembiricha yemvura, iyo moleky chimiro cheHPMC, iyo molecular uremu uye makemikari kugadziridzwa. Kumusoro kumusoro, chiyero chekunyungudika chinokurumidza, kazhinji mune chikamu che60 ° C kusvika 90 ° C, iyo yekunyorovesa mhedzisiro yakanaka. Paunenge uchishandisa mvura inopisa yekunyungudika HPMC, inodikanwa kuti utarise kudzora tembiricha yemvura uye yekushambadzira nguva yekudzivisa kukanganisa kwakanyanya kwekuwedzera kwakanyanya kwekuita kwayo.