Hydroxypruppropyl methylcellose uye hypromelose zvakafanana?

HydroxyPropyl methylcellose (HPMC) uye hypromellose mazwi anowanzoshandiswa nenzira inoshandurwa, asi vanoreva chinhu chimwe chete. HPMC iri synthetic inobva cellulose, uye hypromellose ndiyo nyika yepasi rese isiri yezita (Inn) yeiyi denderedzwa. Aya mazwi anowanzo shandiswa mune maindasitiri emishonga uye ezvekudya, pakati pevamwe, nekuda kwezvivakwa zvavo zvinoedza.

Hydroxyprusyl methylcellose (HPMC) / Hyplompomllose Chimiro:

Hydroxypruppropyl methylcellose ndeye yakagadziridzwa cellulose polymer. Iko kugadziridzwa kunosanganisira kuwedzera kwehydroxypruppropyl uye mapoka mapoka kune iyo cellulose backbone. Cellulose chiitiko chaicho chinoitika chomuzvarirwo Sumo yeHydroxyPropyl (-Och2ch (OH) ch3) ch3) Ch3)

Dhigirii rekutsiva Panyaya yeHPMC, misiyano muDS inogona kukonzera mamakisi akasiyana nezvivakwa zvakasiyana, zvichiita zvinhu zvakasiyana siyana zvekushandisa zvakasiyana.

Hunhu hwe hydroxyprupyl methylcellose:
Solubility uye Gel Kuumbwa:
HPMC inonyungudika mumvura pamusoro pehuremu hwakawedzera tembiricha, uye iyo solubility inoenderana nezvinhu zvakadai sedanho rekutsiva uye suremu. Kuvapo kwehydroxypropyl uye mapoka mapoka kunobatsira kuti isimbe mumvura inotonhora, ichiita kuti iite kuti ishandiswe mune dzakasiyana siyana mafambiro.

Viscosity:
Imwe yeiyo yakakosha zvivakwa zveHPMC ndeyekugona kwayo kuchinja visikopa yemhinduro. Mavara akasiyana eHPMC ane akasiyana viscookiti anowanikwa zvichienderana nezvinodiwa chaizvo nezvakaumbwa.

Firimu rinoumba zvivakwa:
HpMC mafomu akajeka uye anochinjika mafirimu, achiita kuti zvive zvakakosha mukubatanidza zvikumbiro muindasitiri yemishonga uye ezvekudya. Firimu-kugadzira zvivakwa zvinonyanya kukosha mukugadzirwa kweiyo omarara solid dosage mafomu uye confecicerery yekuvhara.

Simbisa:
HPMC inoratidza kugadzikana pamusoro penzvimbo yakafara p p Iyo inoramba enzymatic kusvibiswa uye kurwiswa kwemicrobial, kuchiva kusimba kwezvigadzirwa zvemishonga.

Pfektaceutical application:
Piritsi rinobatanidza:
HPMC inozoshandiswa zvakanyanya muindasitiri yemishonga yebhatani yekuvhara. Mafirimu emazwi anoshanda akasiyana-siyana zvinangwa, kusanganisira kuravira masking, kuchengetedza zvinodhaka kubva pazvinhu zvemunharaunda, uye kudzora kusunungurwa.

Yakaburitswa Kuburitswa Kugadzirira:
Inodzorwa uye yakasarudzika kuburitswa kwezvinodhaka chikamu chakakosha chekuvandudza zvinodhaka. HPMC inoshandiswa kuumba matrix masisitimu ayo anobvumidza kuburitswa zvishoma nezvishoma kweiyo inoshanda mishonga yemishonga (APSI) pamusoro kwenguva yakareba.

Ophthalms gadziriro:
MuOphthalmic mafambiro, HPMC inoshandiswa kuwedzera iyo visikoka yeziso uye inowedzera nguva yekufona neyeoxular pamusoro. Izvi zvinokwidziridza mhedzisiro yemishonga yemushonga.

Zvepamusoro uye zveTransdermal Zvikumbiro:
HPMC inobatanidzwa mumamiriro ekumusoro semagiri nemakiromita kuti upe viscosity uye kugadzirisa kuwanda kwechigadzirwa. Iyo inoshandiswawo mune transdermal patches kudzora kusunungurwa kwezvinodhaka kuburikidza neganda.

Muromo Wemuromo:
HydroxyPropyl methylcellose inoshandiswa mukuumbwa kwemuromo wemuromo madhiri emhando dzekusimudzira viscosity, kumisa zvikamu, uye kuvandudza palatability.

Maindasitiri ezvekudya:
Thickener:
HPMC inoshandiswa seyakaomerera mumiririri mune akasiyana ezvigadzirwa zvekudya, kusanganisira masaga, zvipfeko uye zveshuwa. Kugona kwayo kushandura viscosity kunobatsira iyo yekupedzisira chigadzirwa kuwana iyo yaunoda chimiro.

Thickener:
Mune zvimwe zvekushandisa zvekudya, HPMC inogona kuita segomba rejeya, kubatsira kuumba gels kana kusimbisa emulsions.

Girazi uye majasi:
HPMC inoshandiswa mukudya kwemvura uye marara kuti uvandudze kuderedza, kutaridzika uye nekuchengetedzeka. Iyo inoumba firimu rinojeka rinowedzera kufadza kwekuona kwezvigadzirwa zvekudya.

Kutsiva mafuta:
Se hydrocolloid, HPMC inogona kushandiswa semafuta ekutsiva mumafuta-mafuta ekudya kana emafuta-emafuta uye muromo wakafanana nezvigadzirwa zvine mafuta epamusoro.

Zvinonetsa uye kufunga:
Nepo hydroxyprusypropyl methylcellose ndeye zvinhu zvakasiyana-siyana zvine huwandu hwekushandisa, pane zvimwe kufunga uye nematambudziko mukushandisa kwayo:

Tembiricha yekunzwa:
Iyo solubility yeHPMC inokanganiswa nekushisa. Mamwe mamakisi anogona kuratidzira akaderedzwa solubility pamushingi akanyanya, achida kunyatsofungisisa mukuumbwa.

Hygroscopicity:
HPMC iri hygroscopic, zvichireva kuti inobvisa zvinyoro-nyoro kubva munzvimbo yemagariro. Ichi chivakwa chinoda kutariswa mukuumbwa uko zvinonyungunusa zvirimo zvinokosheswa.

Zvinodhaka-polymer kuwirirana:
Muchiremba emishonga, kuwirirana pakati pezvinodhaka uye polymer kwakakosha kuti uve nechokwadi chekugadzikana uye kushanda kwechigadzirwa chekupedzisira.

Gonulatory Status:
HydroxyPropyl methylcellose yakagamuchirwa zvakanyanya uye yakatenderwa nemasangano ekudzora seUS Yakanyorwa muPharmacopeia seyakazivikanwa kuti gadziriro yemishonga yekugadzirira mishonga.

HydroxyPropyl methylcellose, inowanzozivikanwa seHyprollose, inzvimbo yeCliprountional polmer ine huwandu hwakawanda hwekushandisa mumisheni uye maindasitiri ezvekudya. Zvivakwa zvaro zvakasarudzika, kusanganisira solubility, viscossity modulation, firimu-kugadzira kugona uye kugadzikana, ita chinhu chakakosha chakasiyana mumhando dzakasiyana siyana.

Kubva kuhembe dzehembe uye dzakasunungurwa Iko kugona kwekugadzirisa zvivakwa zvayo nekugadzirisa iyo degree rekutsiva uye suremu huremu hunowedzera kunobatsira mukuchinja kwayo mune dzakasiyana mashandisiro.