Joseph Brama akagadzira maitiro ekuwedzera ekugadzirwa kwemapipi anotungamira mukupera kwegumi nemasere. Yakanga isiri kusvika pakati pezana ramakore rechi19 iyo inopisa-nyauka tekinoroji yakatanga kushandiswa muindasitiri yePlonde. Yakatangwa kushandiswa mukugadzirwa kwekusimbisa mapolymer coatings ye waya yemagetsi. Nhasi unopisa Melt Extrussiology Inoshandiswa zvakanyanya kushandiswa kwete mukugadzirwa kwezvinhu zvePolymer, asiwo mukugadzirwa uye kusanganisa puranymers ivo pachavo. Parizvino, anopfuura hafu yezvigadzirwa zvepurasitiki, kusanganisira mapurasitiki mabhegi, masheya epurasitiki uye mapurasitiki mapepa, anogadzirwa uchishandisa maitiro aya.
Gare gare, iyi tekinoroji zvishoma nezvishoma yabuda mumunda wemishonga uye zvishoma nezvishoma yakava tekinoroji isingaverengeki. Iye zvino vanhu vanoshandisa inopisa-mettrusion tekinoroji kugadzirira granules, mahwendefa ekusunungurwa, transdermal uye etritmucosal drug system etc. Nei vanhu vachifarira iyi tekinoroji izvozvi? Icho chikonzero chinonyanya kukosha nekuti chakafanana neyakagadzirwa chetsika maitiro munguva yakapfuura, inopisa melt Extrussion tekinoroji ine zvinyorwa zvinotevera:
Kuvandudza huwandu hwekuvhunduka hwemishonga isinganyanyoka
Pane zvakanakira kugadzirira kusunungurwa-kusunungura mafomu
Kugadzirira kweGastrointestinal Kuburitsa vamiririri vane mamiriro chaiwo
Kuvandudza Exccient Compress
Maitiro ekunyoroveswa anoonekwa mune imwe nhanho
Vhura nzira nyowani yekugadzirira micropellets
Pakati pavo, cellulose ether anoita basa rakakosha mukuita uku, ngatitarisei kushandiswa kweshandisirwo ye cellulose yather mazviri!
Kushandiswa kweTETHYL Cellulose
Ethyl cellulose rudzi rwe hydrophobic ether cellulose. Mumunda wemishonga, iye zvino ashandiswe mumusoro wenyaya wezvinhu zvinoshanda, solvent uye extrusion granation, pombi inovhara uye seyakajaira mahwendefa ekudziviswa uye mabhebhi. Ethyl Cellulose inogona kuwedzera akasiyana mese menyu. Girazi rayo rekushandura tembiricha ndeyegumi nemaviri kusvika gumi nemaviri emadhigiri Celsius, uye iyo Crystal yekunyungudza inonyungudika ndeye minus 180 degrees celsius. EtHyl Cellulose sarudzo yekuparadza nekuti inoratidza iyo thermoplastic midziyo pamusoro pegirazi tembiricha uye pazasi pekushisa kwaro kwakashata.
Kuti udzore girazi rekushandura tembiricha yePolymers, iyo nzira yakajairika ndeyekuwedzera mapurasitiki, saka inogona kuongororwa pakudziya kwakadzika. Zvimwe zvinodhaka zvinogona kuita sepombananidzi pachavo, saka hapana chikonzero chekuwedzera zvakare mapurasitiki panguva yekugadzira zvinodhaka maitiro. Semuenzaniso, yakawanikwa kuti mafirimu akawedzera ane ibuprofen uye etyl cellulose aive aine yakaderera girazi transition tembiricha pane mafirimu ane ethyl chete cellulose. Iyi mafirimu anogona kugadzirwa muurabhoritari aine-kutenderera mapatya-screw anopararira. Vatsvagiriwo vanovhunawo kuita hupfu uye vozoita kuongororwa kwekunyora. Izvo zvakazowedzera kuwedzera huwandu hweIbuprofen inogona kudzikisa girazi tembiricha.
Imwezve muedzo yaive yekuwedzera hydrophilic excivilics, hypromelose, uye xanthan gamu kuenda kuEtiylcellose uye ibuprofen micromatrices. Izvo zvakagumiswa kuti micromatrix inogadzirwa neiyo inopisa-melt Extrates yekuwedzera yaive neyakagara ichitakura zvinodhaka pane zvigadzirwa zviripo. Vaongorori vakagadzira micromatrix vachishandisa iyo-inotenderera-inotenderera laboratory setup uye twin-screw inopararira ne3-mm cylindrical kufa. Maoko akacheka-ruoko akagadzirwa aive 2 mm kureba.
Hyplompelose kushandiswa
HydroxyPropyl methylcellose ndeye hydrophilic cellelose ether inopika mune yakajeka kana zvishoma makore mashoma emvura mumvura inotonhora. Iyo mhinduro yemvura ine nzvimbo yemusoro, yakakwira transparency uye yakagadzikana kuita. Solubility inosiyana neViscosity. Iyo yakadzika viscosity, iyo yakakura solubility. Zvivakwa zveHydroxyPropropyl methylcellose zvine zvisizvo zvakasiyana zvakasiyana, uye kupaza kwaro mumvura hakuna kukanganiswa neiyo ph kukosha.
Muindasitiri yemisheni, inowanzoshandiswa mukudzorwa matrix, piritsi inokatyamadza, etc.girazi tembiricha yechiCelsius Nekuda kweiyo yakakwirira girazi tembiricha uye yakaderera yekushambadzira tembiricha, haina kushandiswa zvakanyanya mukupisa kwetsamba yekuwedzera. Kuti uwedzere kuwedzera kweshandisirwo, imwe nzira ndeyekusanganisa chete huwandu hwakawanda hweplasticzer mune yekufananidza maitiro sezvo nyanzvi mbiri dzakati,
Ethylcellulose uye hydroxypronylmethylcellose inogona kusanganiswa nenzira yakasarudzika mukutumira mishonga. Imwe yeaya mafomu madhiragedhi ndeye kushandisa ethylcellose seyekunze tube, uye wozogadzirira giredhi rehyproselose. Base cellulose core.
Iyo Ethylcellose Tubing inogadzirwa uchishandisa inopisa-nyungudika muchina wekutenderera uchiisa mhete yesimbi yekufa, iyo yakaitwa mumusoro nekudziya kwekereke, ichiteverwa neHomogenization. Iyo core zvinyorwa zvinobva zvawairwa nemanjeya mupipi. Chinangwa cheichi chidzidzo chaive chekubvisa mhedzisiro yekuputika iyo dzimwe nguva inoitika muHydroxyprusyl Metrix mahwendefa matrix. Vaongorori vakawana musiyano wekuburitsa kwehydroxyprosyl methylcellose yeiyo viscosity, zvakadaro, kutsiva hydroxyprosyl methylcellose ne methylcellose yakakonzerwa nekukurumidza kuburitswa.
Maonero
Kunyangwe kupisa kuchindira kwehunyanzvi hunyanzvi hutsva muindasitiri yemishonga, inokwezva kutarisisa kwakawanda uye inoshandiswa kuvandudza kugadzirwa kwemhando dzakasiyana-siyana dzemhando dzakasiyana uye masisitimu. Kupisa-nyauka Extrusil Technology kwave kutungamira tekinoroji yekugadzirira kusimba kwakasimba kunze kwenyika. Nekuti nheyo dzayo dzehunyanzvi dzakafanana nenzira dzakawanda dzekugadzirira, uye yakaiswa mune mamwe maindasitiri kwemakore mazhinji uye yakaunganidza ruzivo rwakawanda, ine tarisiro yakakura yekuvandudza. Nekunhuhwirira kwekutsvagisa, zvinotendwa kuti kushandisa kwayo kuchawedzera kuwedzerwa. Panguva imwecheteyo, iyo inopisa-mettrusion tekinoroji ine zvishoma kuonana nezvinodhaka uye huwandu hwakanyanya hwekutakura. Mushure mekushandurwa kune iyo misheni indasitiri, inotendwa kuti Yayo GMP Shanduko ichave nekukurumidza.
Kutumira Nguva: Kukadzi-14-2025